A5028257602- Bladder and Urothelial Cancer Treatments
- Kidney Stones and Urolithiasis Treatments
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Ureteral procedures and complications
- Prostate Cancer Diagnosis and Treatment
- Pelvic floor disorders treatments
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Urinary Tract Infections Management
- Enhanced Recovery After Surgery
- MRI in cancer diagnosis
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Health, Medicine and Society
- Urologic and reproductive health conditions
- Nicotinic Acetylcholine Receptors Study
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- Lung Cancer Treatments and Mutations
- Therapeutic Uses of Natural Elements
- Biomedical Research and Pathophysiology
- Cancer Genomics and Diagnostics
University of Bern
2015-2025
University Hospital of Bern
2014-2025
University Hospital of Lausanne
1988-2024
University of Lausanne
2019-2024
Cleveland Clinic Lerner College of Medicine
2024
Hôpital Orthopédique de la Suisse Romande
2020-2023
Urology Team
2023
Medical University of Vienna
2019
The University of Texas MD Anderson Cancer Center
2012-2016
Chirurgische Universitätsklinik Heidelberg
2006
No AccessJournal of UrologyAdult Urology1 Oct 2011Super Extended Versus Pelvic Lymph Node Dissection in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Comparative Study Pascal Zehnder, Urs E. Studer, Eila C. Skinner, Ryan P. Dorin, Jie Cai, Beat Roth, Gus Miranda, Frédéric Birkhäuser, John Stein, Fiona Burkhard, Sia Daneshmand, George N. Thalmann, Inderbir S. Gill, and Donald G. Skinner ZehnderPascal Zehnder University Southern California Institute Urology, Catherine Joseph...
Nephrolithiasis is one of the most common conditions affecting kidney and characterized by a high risk recurrence. Thiazide diuretic agents are widely used for prevention recurrence stones, but data regarding efficacy such as compared with placebo limited. Furthermore, dose–response also
The α-chain of the nicotinic acetylcholine receptor carries binding sites both for cholinergic ligands and most experimentally induced or naturally occurring antibodies to native receptor. By means expression cloning in Escherichia coli , fusion proteins were derived from specific fragments a complementary DNA encoding mouse α-chain, allowing mapping toxin-binding site residues 160-216 main immunogenic region 6-85. This approach permits independent study different functional domains complex...
To evaluate oncological outcome trends over the last three decades in patients after radical cystectomy (RC) and extended pelvic lymph node (LN) dissection.Retrospective analysis of University Southern California (USC) RC cohort (1488 patients) operated with intent to cure from 1980 2005 for biopsy confirmed muscle-invasive urothelial bladder cancer. focus on outcomes unexpected (cN0M0) LN-positive patients, USC subset was Berne (UB) (combined subgroup 521 patients). Patients were grouped...
We compared the long-term results of minimally invasive endourological intervention and open surgical revision in patients with a nonmalignant ureteroileal stricture.We retrospectively evaluated records 74 (85 renal units) treated for unilateral or bilateral strictures. Overall, 96 35 procedures were performed. Balloon dilatation Acucise® Ho:YAG laser endoureterotomy used as interventions. Open stricture resection end-to-side-reanastomosis was alternate therapy. Treatment success defined...
Fibroblast growth factor receptors (FGFRs) are activated by mutation and overexpressed in bladder cancers (BCs), FGFR inhibitors currently being evaluated clinical trials BC patients. However, cells display marked heterogeneity their responses to inhibitors, the biological mechanisms underlying this not well defined. Here we used a novel inhibitor of FGFRs 1–3 RNAi determine effects inhibiting FGFR1 or FGFR3 panel human cell lines. We observed that was expressed also "mesenchymal" markers...
To describe stone-free rates and complications of ureteroscopic treatment for impacted compared with non-impacted ureteral stones evaluate predictive variables impaction. The Clinical Research Office the Endourological Society prospectively collected 1 consecutive year data from 114 centers worldwide. Patients eligible inclusion were patients treated ureteroscopy stones. Patient characteristics, details, outcomes regard to stone Logistic regression analyses conducted explore impaction...
Background: Low bone mass and fractures are common among kidney stone formers, yet it remains unclear whether thiazides can help preserve mass. We aimed to evaluate the effectiveness of a range hydrochlorothiazide (HCTZ) doses compared placebo on mineral density (BMD) over three-year period. Methods: This post-hoc analysis was conducted data from NOSTONE trial, multicenter, randomized, controlled study. A total 416 adults with recurrent calcium stones participated in study, receiving either...
To prospectively assess the potential of noninvasive diffusion-weighted magnetic resonance (MR) imaging to depict changes in microperfusion and diffusion patients with acute unilateral ureteral obstruction.The local ethics committee approved study protocol. Informed consent was obtained. Diffusion-weighted MR performed 21 (two women, 19 men; mean age, 43 years +/- 10 [standard deviation]) obstruction due a calculus diagnosed at unenhanced computed tomography. A control group (one woman, 15...
Abstract Despite the possible benefit from avoiding stone surgery with all its complications, oral chemolysis is rarely performed in patients urinary stones suspected of uric acid content. Among reasons for limited use sparse and low-quality data on efficacy lack reliable factors predicting outcome. We thus a retrospective single-center cohort study 216 (median patient age 63 years) 272 renal (48%) and/or ureteral (52%) treated 01/2010 to 12/2019. Patients low urine pH (< 6), density upon...
Zusammenfassung Harnleitersteine führen häufig zu Notfallbesuchen aufgrund von Nierenkoliken. Für die Behandlung dieser Steine stehen verschiedene Verfahren zur Verfügung, wie z. B. medikamentöse Steinaustreibungstherapie (MET) extrakorporale Stosswellenlithotripsie (ESWL) und Ureteroskopie. Die orale Chemolyse ist eine Behandlungsoption, speziell für Harnsäuresteine geeignet ist. Es zeigte sich, dass Entfernung Harnleiterstents spontane Passage Harnleitersteinen erleichtert. Angesichts der...
Monoclonal antibodies (mAbs) to the main immunogenic region (MIR) bind fusion proteins containing 37-200 of alpha chain Torpedo, mouse, and chicken nicotinic acetylcholine receptor. In case mouse chain, these mAbs react with sequence 61-216 but not 74-216. A synthetic peptide M1, residues 61-76 also binds anti-MIR mAbs, showing that all or part their binding site is included in this region. The conformational dependence epitope specificity are discussed.
No AccessJournal of UrologyAdult Urology1 May 2009Benign Prostatic Obstruction and Parkinson's Disease—Should Transurethral Resection the Prostate be Avoided? Beat Roth, Urs E. Studer, Clare J. Fowler, Thomas M. Kessler RothBeat Roth Department Urology, University Bern, Switzerland , StuderUrs Studer FowlerClare Fowler Uro-Neurology, The National Hospital for Neurology Neurosurgery, College London Hospitals NHS Foundation Trust, Institute Neurology, London, United Kingdom KesslerThomas View...
To analyse the long-term outcomes of patients with lymph node (LN)-positive bladder cancer, who did not receive any adjuvant therapy after radical cystectomy (RC) and extended pelvic dissection (ePLND).We conducted a retrospective, combined cohort analysis based on two prospectively maintained databases from University Southern California Bern. Eligible underwent RC ePLND for cN0M0 disease but were found to have LN-positive disease. No patient had neoadjuvant therapy, all negative surgical...