A5033770560- Blood Pressure and Hypertension Studies
- Colorectal Cancer Screening and Detection
- Renal Diseases and Glomerulopathies
- Renal Transplantation Outcomes and Treatments
- Gastric Cancer Management and Outcomes
- Heart Rate Variability and Autonomic Control
- Hemodynamic Monitoring and Therapy
- Organ Transplantation Techniques and Outcomes
- Polyomavirus and related diseases
- Dialysis and Renal Disease Management
- Organ Donation and Transplantation
- Hormonal Regulation and Hypertension
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular Health and Disease Prevention
- Parvovirus B19 Infection Studies
- Renal and Vascular Pathologies
- Colorectal Cancer Surgical Treatments
- Vasculitis and related conditions
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Lanthanide and Transition Metal Complexes
- Kidney Stones and Urolithiasis Treatments
- Advanced MRI Techniques and Applications
- Pregnancy and preeclampsia studies
- Esophageal Cancer Research and Treatment
- Pediatric Urology and Nephrology Studies
University Hospital of Basel
2016-2025
University of Basel
2005-2025
Hospital Base
2024
Hypertension Institute
2023
Ludwig-Maximilians-Universität München
2020
University of Applied Sciences Landshut
2019
Medical University of Vienna
2015-2017
Universitätszahnklinik Wien
2015
LMU Klinikum
2014-2015
Technical University of Munich
2005-2015
<h3>Background</h3> Screening colonoscopy (SC) outcome quality is best determined by the adenoma detection rate (ADR). The substantial variability in ADRs between endoscopists may reflect different skills, experience and/or equipment. <h3>Objective</h3> To analyse potential factors that influence ADR variance, including case volume. <h3>Design</h3> 12 134 consecutive SCs (mean age 64.5 years, 47% men) from 21 Berlin private-practice colonoscopists were prospectively studied during 18 months....
Nephrolithiasis is one of the most common conditions affecting kidney and characterized by a high risk recurrence. Thiazide diuretic agents are widely used for prevention recurrence stones, but data regarding efficacy such as compared with placebo limited. Furthermore, dose–response also
PURPOSE The anti-NECTIN4 antibody-drug conjugate enfortumab vedotin (EV) is approved for patients with metastatic urothelial cancer (mUC). However, durable benefit only achieved in a small, yet uncharacterized patient subset. NECTIN4 located on chromosome 1q23.3, and 1q23.3 gains represent frequent copy number variations (CNVs) cancer. Here, we aimed to evaluate amplifications as genomic biomarker predict EV response mUC. MATERIALS AND METHODS We established NECTIN4-specific fluorescence...
Defining the clinical relevance of donor-specific HLA-antibodies detected by single-antigen flow-beads (SAFB) is important because these assays are increasingly used for pretransplant risk assessment and organ allocation. The aims this study were to investigate which extent HLA-DSA SAFB represent a antibody-mediated rejection (AMR) diminished allograft survival, define characteristics predictive AMR.In retrospective 334 patients with negative complement-dependent cytotoxicity crossmatches,...
Early detection of polyomavirus BK (BKV) viremia and reduction immunosuppression is recommended for preventing polyomavirus-associated nephropathy (PyVAN), but systematic histological evaluations were not performed in previous studies. We routinely screen decoy cells and, if positive, measure plasma BKV-loads. In a cohort 203 consecutive renal transplantations from 2005-2008, 38 patients (19%) developed BKV-viremia treated with immunosuppression. Based on subsequent allograft biopsy results...
Subclinical tubulitis has been associated with the later development of interstitial fibrosis and tubular atrophy (IF/TA), leading to diminished allograft survival. The aim this study was investigate how concentrations urinary CXC-receptor 3 (CXCR3) chemokines (i.e. CXCL4/9/10/11) CCL2 relate extent subclinical tubulitis. Using ELISA, CXCR3 chemokines, injury markers NGAL alpha1-microglobulin [alpha1 m]) were measured in patients stable estimated GFR >or=40 mL/min exhibiting normal histology...
Progressive aortic stiffening eventually leads to left ventricular (LV) hypertrophy and heart failure if untreated. Anti-hypertensive agents have been shown reverse this some extent. The effects of sacubitril/valsartan (LCZ696), a dual-action angiotensin receptor blocker (ARB), neprilysin inhibitor, on arterial stiffness LV remodelling not investigated.This was randomized, multi-centre, double-blind, double-dummy, active-controlled, parallel group, study compare the cardiovascular with those...
Control of polyomavirus BK (BKV) is achieved by reducing immunosuppression allowing an effective BKV-specific T-cell response. The morphology resolving BKV-associated nephropathy (PyVAN) has not been systematically investigated. Ninety-nine surveillance biopsies 35 patients with BKV viremia treated exclusively reduction were scored according to Banff criteria and grouped relative as pre-, increasing, decreasing post-BKV viremia. Thirty-four (97%) cleared after a median 9 months...
The World Health Organization (WHO) declared the COVID-19 outbreak a “Public Emergency of International Concern” on 30 January 2020, after rapid spread from few initial cases to thousands across China and introductions into several other countries. On 11 March WHO classified as pandemic. first in Switzerland, Basel-Stadt, Basel-Landschaft were confirmed 25 February, 27 February 28 2020. As 22 April there are 28,154 including 933 811 Cantons Basel-Stadt Basel-Landschaft, respectively....
Background. Tubulointerstitial injury due to rejection leads tubular atrophy (TA)/interstitial fibrosis (IF) followed by deterioration of allograft function. This study investigated whether urinary biomarkers can detect subclinical tubulitis found in protocol biopsies allowing for a noninvasive screening procedure. Methods. Four rigidly defined groups (stable transplants with normal histology [n=24], stable [n=38], patients clinical Ia/Ib [n=18], and other pathologies [n=20]) were compared...
<h3>Background</h3> As screening colonoscopy becomes more widespread, the costs for histopathological assessment of resected polyps are rising correspondingly. Reference centres have published highly accurate results endoscopic polyp classification. Therefore, it has been proposed that, smaller polyps, differential diagnosis that guides follow-up recommendations could be based on endoscopy alone. <h3>Objective</h3> The aim was to prospectively assess whether high accuracy as reported by...
Objectives Standard operating procedures for office blood pressure measurement (OBPM) vary greatly between guidelines and studies. We aimed to compare the difference a single OBPM mean of three following measurements. Further, we studied how many patients with possible hypertension may be missed due short-term masked (STMH) might overdiagnosed white coat (STWCH). Design setting In this cross-sectional, single-centre trial, 1000 adult subjects were enrolled. After 5 min rest, four sequential...
In sub-Saharan Africa (SSA), epidemiological data for chronic kidney disease (CKD) are scarce. We conducted a prospective cross-sectional study including 952 patients in an outpatient clinic Tanzania to explore CKD prevalence estimates and the association with cardiovascular infectious disorders. According KDIGO, we measured albumin-to-creatinine ratio calculated eGFR using CKD-EPI formula. Factors associated were by logistic regression. Venn diagrams modelled visualize interaction between...
Background: Low bone mass and fractures are common among kidney stone formers, yet it remains unclear whether thiazides can help preserve mass. We aimed to evaluate the effectiveness of a range hydrochlorothiazide (HCTZ) doses compared placebo on mineral density (BMD) over three-year period. Methods: This post-hoc analysis was conducted data from NOSTONE trial, multicenter, randomized, controlled study. A total 416 adults with recurrent calcium stones participated in study, receiving either...
Sirolimus inhibits human fibroblast cell proliferation in cultures from transbronchial biopsies of lung transplant recipients. However, a few cases interstitial pneumonitis and bronchiolitis obliterans organizing pneumonia have been recently described solid organ recipients, including fatality heart recipient. We studied the patterns pulmonary adverse effects associated with sirolimus 4 renal recipients who developed opacities on chest radiograph, which were proved to be noninfectious...
Background A main challenge in the therapy of drug dependent individuals is to help them reactivate interest non-drug-associated activities. Among these activities, social interaction doubly important because treatment adherence itself depends on it. We previously developed a rat experimental model based conditioned place preference (CPP) paradigm which only four 15-min episodes with gender- and weight-matched male conspecific (i) reversed CPP from cocaine despite continuing training (ii)...
Abstract A cuffless blood pressure (BP) device (TestBP) using pulse transit time is in clinical use, but leads to higher BP values compared a cuff-based 24 h-BP reference (RefBP). We evaluated the impact of recent software update on results and TestBP’s ability differentiate between normo- hypertension. 71 individuals had TestBP (Somnotouch-NIBP) RefBP measurements simultaneously performed either arm. with version V1.5 were V1.4 RefBP. Mean h (± SD) for RefBP, TestBP-V1.4 TestBP-V1.5...