A5086829899- Neurotransmitter Receptor Influence on Behavior
- Treatment of Major Depression
- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Pharmaceutical studies and practices
- Neuropeptides and Animal Physiology
- Memory and Neural Mechanisms
- Ion channel regulation and function
- Pain Mechanisms and Treatments
- Pharmacological Effects and Toxicity Studies
- Electroconvulsive Therapy Studies
- Pharmacogenetics and Drug Metabolism
- Neuroendocrine regulation and behavior
- Nicotinic Acetylcholine Receptors Study
- Forensic Toxicology and Drug Analysis
- Bipolar Disorder and Treatment
- Alcohol Consumption and Health Effects
- Anesthesia and Sedative Agents
- Epilepsy research and treatment
- Stress Responses and Cortisol
- Substance Abuse Treatment and Outcomes
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
Innsbruck Medical University
2015-2025
Universität Innsbruck
2015-2025
Ospedale di Bolzano
2021
University of Bologna
2021
Tirol Kliniken
2018-2019
Klinik und Poliklinik für Psychiatrie und Psychotherapie
2005-2018
Johannes Gutenberg University Mainz
2004-2007
University Hospital Innsbruck
2004
University of Bonn
2004
Hôpital de Cery
2004
Therapeutic drug monitoring (TDM), i. e., the quantification of serum or plasma concentrations medications for dose optimization, has proven a valuable tool patient-matched psychopharmacotherapy. Uncertain adherence, suboptimal tolerability, non-response at therapeutic doses, pharmacokinetic drug-drug interactions are typical situations when measurement medication is helpful. Patient populations that may predominantly benefit from TDM in psychiatry children, pregnant women, elderly patients,...
Therapeutic Drug Monitoring (TDM) enables the clinician to adjust dosage of drugs according characteristics individual patient. The interdisciplinary TDM group Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP) has worked out consensus guidelines assist psychiatrists and laboratories involved in psychotropic drug analysis optimise use drugs. Five research-based levels recommendation were defined with regard routine monitoring plasma concentrations for dose...
The quantification of antipsychotic levels in blood, also known as therapeutic drug monitoring (TDM), is a potentially useful tool modern personalized therapy that can be applied to augment use and dosing decisions. application TDM for antipsychotics helpful numerous challenging clinical scenarios, such lack response, relapse, or adverse reactions (ADRs) related treatment. benefits may particularly evident the treatment highly vulnerable patient subgroups, children, adolescents, pregnant...
ABSTRACT Little is known how social interaction, if offered as an alternative to drug consumption, affects neural circuits involved in reinforcement and substance dependence. Conditioned place preference (CPP) for cocaine (15 mg/kg i.p.) or interaction minutes) stimulus was investigated male Sprague‐Dawley rats. Four episodes with a adult conspecific completely reversed CPP were even able prevent reacquisition of CPP. Social also CPP‐induced expression the immediate‐early gene zif268 nucleus...
Chronic social stress is one of the most important factors responsible for precipitation depressive disorder in humans. In recent years, impact on development psychopathologies has been thoroughly investigated preclinical animal studies. We have shown recently that behavioural effects chronic rats can be reversed by citalopram and fluoxetine. This study designed further pharmacological validation paradigm as a model symptoms rats. For this, were subjected to 5 weeks daily defeat parallel...
Quetiapine is a second-generation antipsychotic with favourable risk/benefit profile that increasingly used in psychiatric patients. Similar to other antipsychotics, the efficacy and adverse effects of quetiapine depend much more on actual plasma concentration active drug than prescribed dose. The present study investigated whether age, gender, body weight or certain comedications influence by determining levels tandem mass spectrometry 94 (36 male 58 female) patients aged 42.2 +/- 20.0...
A main challenge in the therapy of drug dependent individuals is to help them reactivate interest non-drug-associated activities. We previously developed a rat experimental model based on conditioned place preference (CPP) paradigm which only four 15-min episodes social interaction with gender- and weight-matched male Sprague Dawley (1) reversed CPP from cocaine despite continuing training (2) prevented reinstatement CPP. In present study, we investigated sensory modalities composite...
We previously developed rat experimental models based on the conditioned place preference (CPP) paradigm in which only four 15-min episodes of dyadic social interaction with a sex- and weight-matched male Sprague Dawley (SD) (1) reversed CPP from cocaine to despite continuing training, (2) prevented reacquisition/re-expression CPP. In concurrent conditioning schedule, pairing one compartment other 15 mg/kg injections, rats spent same amount time both compartments most rewarding sensory...
3,4-Methylenedioxymethamphetamine (MDMA; ‘ecstasy’) is one of the most prevalent illegal drugs abuse among European adolescents, a population not generally experienced with respect to ‘hard’ such as cocaine. We, therefore, determined reinforcing effect intravenously self-administered MDMA in fixed ratio 1 time-out 150 s schedule reinforcement rats that were truly drug naive and compared it cocaine-trained rats. The [0.032–10 mg/(kg·injection)] did differ between drug-naive ones. sensitized...
There is limited information on gender- and age-specific effects plasma concentrations of risperidone its active metabolite, 9-hydroxyrisperidone. The present study investigated dose- weight-adjusted metabolite in three age groups (45 years, 45-60 over 60 years). Gender-specific differences were examined the whole sample for premenopausal subgroup. One hundred twenty-nine patients (18-93 years) included study, 52 (40%) male 77 (60%) female. Concentrations 9-hydroxyrisperidone measured at...
Neurotransmitter release in the nucleus accumbens core (NACore) during acquisition of remifentanil or cocaine reinforcement was determined an operant runway procedure by simultaneous tandem mass spectrometric analysis dopamine, acetylcholine, and itself. Run times for continually decreased over five consecutive runs experiment. Intra-NACore drug peaked with each intravenous self-administration to pre-run baseline half-lives approximately 10 min. As expected, peaks did not vary between runs....
The human red blood cell ghost Ca 2+ ‐antagonist binding sites were characterized with (±)‐[ 3 H]nimodipine. labelled 1,4‐dihydropyridine bound in a non‐cooperative, reversible manner K d of 52 nM at 25°C to 9.65 pmol sites/mg protein. stereochemistry the domain was evaluated optically pure enantiomers chiral 1,4‐dihydropyridines. In contrast 1,4‐dihydropyridine‐selective receptors on channels electrically excitable tissues, (+) enantiomer nimodipine and (−) benzoxadiazol (PN 200–110) higher...
ORIGINAL RESEARCH article Front. Behav. Neurosci., 24 September 2012Sec. Motivation and Reward Volume 6 - 2012 | https://doi.org/10.3389/fnbeh.2012.00063
Background A main challenge in the therapy of drug dependent individuals is to help them reactivate interest non-drug-associated activities. Among these activities, social interaction doubly important because treatment adherence itself depends on it. We previously developed a rat experimental model based conditioned place preference (CPP) paradigm which only four 15-min episodes with gender- and weight-matched male conspecific (i) reversed CPP from cocaine despite continuing training (ii)...
Background: Therapeutic drug monitoring (TDM) is essential for controlling pharmacogenetic and pharmacokinetic variations optimizing pharmacotherapy. However, its value often underestimated because of nonsystematic recommendations target ranges in the literature. The purpose this study was to emphasize transparency systematization forthcoming Updates Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP)-TDM Consensus Guidelines. Methods: Here, a stepwise method...
Aripiprazole is a novel atypical antipsychotic drug for the treatment of schizophrenia and schizoaffective disorders (1)(2)(3). The metabolized by cytochrome P450 isoenzymes 3A4 2D6 (4). Because high interindividual variability in expression these enzymes, aripiprazole concentration varies among healthy individuals after administration (5). In patients, insufficient response or side effects, such as somnolence, akathisia, nausea, may result from too low concentrations. Therapeutic monitoring...