A5101830632- Pain Mechanisms and Treatments
- Bladder and Urothelial Cancer Treatments
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Neuropeptides and Animal Physiology
- Stress Responses and Cortisol
- Nerve injury and regeneration
- Enhanced Recovery After Surgery
- Acupuncture Treatment Research Studies
- Ion Channels and Receptors
- Pelvic floor disorders treatments
- Sperm and Testicular Function
- Neurotransmitter Receptor Influence on Behavior
- Neuroinflammation and Neurodegeneration Mechanisms
- Memory and Neural Mechanisms
- Musculoskeletal pain and rehabilitation
- Reproductive Biology and Fertility
- Prostate Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Pharmacological Receptor Mechanisms and Effects
- Pharmacological Effects of Natural Compounds
- Healthcare and Venom Research
National Health and Family Planning Commission
2018-2025
Peking University
2014-2025
University of Southern California
2003-2025
Sichuan University
2024
Xiangyang Central Hospital
2024
King University
2024
Zhongnan Hospital of Wuhan University
2023
Wuhan University
2023
Homerton University Hospital NHS Foundation Trust
2023
Keck Hospital of USC
2021
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jul 2003Risk Factors for Patients With Pelvic Lymph Node Metastases Following Radical Cystectomy En Bloc Lymphadenectomy: The Concept Density JOHN P. STEIN, JIE CAI, SUSAN GROSHEN, and DONALD G. SKINNER STEINJOHN STEIN More articles by this author , CAIJIE CAI GROSHENSUSAN GROSHEN SKINNERDONALD View All Author Informationhttps://doi.org/10.1097/01.ju.0000072422.69286.0eAboutFull TextPDF ToolsAdd to favoritesDownload...
No AccessJournal of UrologyAdult Urology1 Oct 2011Super Extended Versus Pelvic Lymph Node Dissection in Patients Undergoing Radical Cystectomy for Bladder Cancer: A Comparative Study Pascal Zehnder, Urs E. Studer, Eila C. Skinner, Ryan P. Dorin, Jie Cai, Beat Roth, Gus Miranda, Frédéric Birkhäuser, John Stein, Fiona Burkhard, Sia Daneshmand, George N. Thalmann, Inderbir S. Gill, and Donald G. Skinner ZehnderPascal Zehnder University Southern California Institute Urology, Catherine Joseph...
The authors report their experience with radical cystectomy for transitional cell carcinoma (TCC) of the bladder comparing clinical outcomes, including complication rates, among older patients versus younger in a high-volume center specializing treatment advanced urinary bladder.A retrospective review was undertaken 1054 who underwent TCC from 1971 through 1997. Four age groups were compared; < 60 years at time (n = 309 patients), 60-69 381 70-79 314 and > or 80 50 patients).The median...
In Brief Primary and metastatic cancers that affect bone are frequently associated with severe intractable pain. The mechanisms underlying the pathogenesis of cancer pain still remain largely unknown. Previously, we have reported sensitization primary sensory dorsal root ganglion (DRG) neurons contributes to in rats. addition, numerous preclinical clinical studies revealed pathological roles interleukin-6 (IL-6) inflammatory neuropathic hyperalgesia. this study, investigated role IL-6...
Risk factors for upper tract recurrence following radical cystectomy transitional cell carcinoma of the bladder are not yet well-defined. We reviewed our population patients who underwent to identify prognostic and clinical outcomes associated with recurrence.From prospective database 1,359 we identified 1,069 treated between January 1985 December 2001. Univariate analysis was completed determine predictive recurrence.A total 853 men 216 women were followed a median 10.3 years (maximum...
Summary Increased fat mass and redistribution are commonly observed in aging populations worldwide. Although decreased circulating levels of sex hormones, androgens oestrogens have been observed, the exact mechanism accumulation during remains obscure. In this study, receptor follicle‐stimulating hormone ( FSH ), a gonadotropin that increases sharply persistently with both males females, is functionally expressed human mouse tissues adipocytes. Follicle‐stimulating was found to promote lipid...
Cognitive behavioral therapy, such as environmental enrichment combined with voluntary exercise (EE-VEx), is under active investigation an adjunct to pharmaceutical treatment for chronic pain. However, the effectiveness and underlying mechanisms of EE-VEx remain unclear. In mice intraplantar injection complete Freund's adjuvant, our results revealed that alleviated perceptual, affective, cognitive dimensions inflammatory These effects on pain were contingent occurrence adult neurogenesis in...
Abstract Introduction Painful diabetic neuropathy (PDN) is a common complication of diabetes. Previous studies have implicated that mitochondrial dysfunction plays role in the development PDN, but its pathogenesis and mechanism not been fully investigated. Methods In this study, we used high‐fat diet/low‐dose streptozotocin‐induced rats as model type 2 diabetes mellitus. Behavioral testing, whole‐cell patch‐clamp recordings dorsal root ganglion (DRG) neurons, complex sensory nerve conduction...
Orthotopic neobladder reconstruction is the preferred method of urinary diversion after radical cystoprostatectomy. We evaluated functional outcomes in male patients orthotopic using a patient questionnaire.Between 2002 and 2009 with bladder cancer were enrolled clinical trial, randomly assigned to undergo T pouch or Studer Male mailed questionnaire 12 more months surgery including items on function, intermittent catheterization, number/size/wetness pads mucus leakage.The response rate was...
Summary Suppression of KCNQ/M channels in dorsal root ganglia neurons is associated with neuronal hyperexcitability and cancer-induced bone pain rats. Bone cancer has a strong impact on the quality life patients, but difficult to treat. Better understanding pathogenic mechanisms underlying will likely lead development more effective treatments. In present study, we investigated whether inhibition contributed primary sensory pathogenesis pain. By using rat model based intratibial injection...
Despite high prevalence of anxiety accompanying with chronic pain, the mechanisms underlying pain-related are largely unknown. With its well-documented role in pain and emotion processing, amygdala may act as a key player pathogenesis neuropathic anxiety. Pain-related plasticity sensitization CeA (central nucleus amygdala) neurons have been shown several models pain. In addition, firing pattern spike output can powerfully affect functional brain nucleus, GABAergic crucial modulation neuronal...
Abstract Exacerbation of pain by chronic stress and comorbidity with stress-related psychiatric disorders, including anxiety depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether forced swim (CFSS)–induced exacerbation neuropathic is mediated integration stress-affect–related information nociceptive in central nucleus amygdala (CeA). We first demonstrated that CFSS indeed produces both depressive-like...
Background: Primary and metastatic cancers that affect bone are frequently associated with severe intractable pain. The mechanisms underlying the development of cancer pain largely unknown. aim this study was to determine whether enhanced excitability primary sensory neurons contributed peripheral sensitization tumor-induced hyperalgesia during condition. In study, using techniques whole-cell patch-clamp recording immunofluorescent staining, single-cell reverse-transcriptase PCR behavioral...
Abstract Background Up‐regulation of transient receptor potential vanilloid subfamily, member 1 ( TRPV1 ) is associated with the development and maintenance cancer pain. The present study aimed to investigate electrophysiological function up‐regulated regulatory effects insulin‐like growth factor‐1 IGF ‐1) on expression in peripheral nerves a rat model bone Methods A pain rats was established by injecting MRMT ‐1 (rat mammary gland carcinoma cells) breast cells into tibia cavity. Thermal...
Rationale: Idiopathic asthenozoospermia (iAZS) is one of the major causes male infertility and has no effective therapeutic treatment. Understanding potential mechanisms that cause it may be helpful in seeking novel targets treatment strategies for overcoming problem low sperm motility iAZS individuals. Methods: Computer-assisted semen analysis (CASA) was utilized to assess motility. RT-qPCR, Western blot, immunofluorescence staining, calcium imaging were performed examine expression...
Primary and metastatic cancers that affect bone are frequently associated with severe intractable pain. The mechanisms underlying the development of cancer pain largely unknown. In this study, we first demonstrated a functional upregulation P2X3 receptors in dorsal root ganglion (DRG) neurons is closely neuronal hyperexcitability cancer-induced MRMT-1 tumor cell-inoculated rats. Second, revealed visinin-like protein 1 (VILIP-1), member proteins belong to family calcium sensor responsible for...
Transient receptor potential vanilloid 1 (TRPV1) receptors are expressed in nociceptive neurons of rat dorsal root ganglions (DRGs) and mediate inflammatory pain. Nonspecific inhibition protein-tyrosine phosphatases (PTPs) increases the tyrosine phosphorylation TRPV1 sensitizes TRPV1. However, less is known about phosphorylation's implication pain, compared with that serine/threonine phosphorylation. Src homology 2 domain-containing phosphatase (Shp-1) a key dephosphorylating In this study,...
Comorbid anxiety and depressive symptoms in chronic pain are a common health problem, but the underlying mechanisms remain unclear. Previously, we have demonstrated that sensitization of CeA neurons via decreased GABAergic inhibition contributes to anxiety-like behaviors neuropathic rats. In this study, by using male Sprague Dawley rats, reported plays key role processing both sensory negative emotional-affective components pain. Bilateral electrolytic lesions CeA, not lateral/basolateral...