A5102708301- Anesthesia and Neurotoxicity Research
- Intensive Care Unit Cognitive Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Pain Mechanisms and Treatments
- Anesthesia and Sedative Agents
- RNA Research and Splicing
- Nerve injury and regeneration
- Polysaccharides and Plant Cell Walls
- Ion channel regulation and function
- Neuroscience and Music Perception
- Neonatal and fetal brain pathology
- Cardiac, Anesthesia and Surgical Outcomes
- Stress Responses and Cortisol
- Tactile and Sensory Interactions
- Neuroscience and Neuropharmacology Research
- Nausea and vomiting management
- Neuropeptides and Animal Physiology
- Multisensory perception and integration
- S100 Proteins and Annexins
- Sports injuries and prevention
- Pediatric Pain Management Techniques
- Polysaccharides Composition and Applications
- Nicotinic Acetylcholine Receptors Study
- Hydrogen's biological and therapeutic effects
- Magnesium Alloys: Properties and Applications
Peking University
2005-2025
Maternal and Child Health Hospital of Sichuan Province
2025
Tianjin University of Science and Technology
2025
Beijing Jishuitan Hospital
2025
Capital Medical University
2025
Beijing Institute of Neurosurgery
2025
National Health and Family Planning Commission
2022-2024
China Medical University
2014-2024
State Key Laboratory of Natural and Biomimetic Drugs
2024
King University
2024
Magnesium, a promising biodegradable metal, has been reported in several studies to increase bone formation. Although there is some information regarding the concentrations of magnesium ions that affect remodeling at cellular level, little known about effect on cell gap junctions. Therefore, this study aimed systematically investigate effects different cells, and further evaluate its junctions osteoblasts. Cultures normal human osteoblasts were treated with 1, 2 3 mM, for 24, 48 72 h. The...
Abstract Hypoxic‐ischemic brain injury (HIBI) in neonates can lead to lifelong cognitive and memory impairment, but protective strategies are lacking at present. It has been demonstrated that autophagy plays a critical role HIBI, while the function of impairment induced by HIBI not tested. In this study, we tested impact on neonatal rats using Morris water maze investigated its possible mechanisms, which were established as model ligating left common carotid artery rats, followed 2‐h...
Neural stem cell (NSC) transplantation is one of the most promising therapeutic strategies for neurodegenerative diseases. However, slow spontaneous differentiation NSCs often hampers their application in neural repair. Although some biological growth factors accelerate NSCs, high cost, short half-life, and unpredictable behavior vivo, as well complexity operation, hinder clinical use. In this study, it demonstrated that hydroxyapatite (HAp), main component bone, form nanorods, can regulate...
This study was aimed at investigating whether sevoflurane inhalation induced cognitive impairment in rats with a possible mechanism involved the event.Thirty-two were randomly divided into four groups of normal saline (NS) + O2, NS (sevo), amyloid-β peptide (Aβ) and Aβ sevo. The received bilateral intrahippocampus injections or Aβ. treated hippocampus harvested after inhaling 30% O2 2.5% sevoflurane. Evaluation function performed by Morris water maze (MWZ) an Aβ1-42 level determined ELISA....
A novel natural polysaccharide (LSP) was isolated and purified from Lactuca sativa L. The structure of LSP characterized using various techniques, including FT-IR, IC, Congo red, XRD, DSC, SEM, AFM, NMR. Furthermore, its in vivo hypoglycemic activity as an adjuvant studied a diabetic mouse model induced by HFD/STZ. findings revealed that possesses molecular weight 1.3 × 10⁶ kDa, with primary structural elements identified →4)-α-D-Glcp-(1→, →4,6)-α-Glcp-(1→, α-Araf-(1→, →6)-β-D-Galp-(1→,...
Cardiac troponin release is generally found in adult athletes after continuous-type endurance exercises or sport competitions. The purpose of this study was to investigate whether the physical stress experienced by adolescents while playing basketball, an intense, intermittent-type sport, could induce transient elevations serum cardiac T (cTnT) and I (cTnI). Serum cTnT cTnI levels 10 male adolescent players (age 15.0 +/- 0.7 yr) were assessed immediately before at 2, 4 24 h a game randomly...
Abstract Neuropathic pain is a pervasive medical challenge currently lacking effective treatment options. Molecular changes at the site of peripheral nerve injury contribute to both and central sensitization, critical components neuropathic pain. This study explores role G-protein-coupled bile acid receptor (GPBAR1 or TGR5) in mechanisms underlying induced by partial sciatic ligation male mice. TGR5 was upregulated injured predominantly colocalized with macrophages. Perisciatic...
Autism spectrum disorder (ASD) is a neurodevelopmental with highly heritable heterogeneity. Mutations of CUB and sushi multiple domains 3 (CSMD3) gene have been reported in individuals ASD. However, the underlying mechanisms CSMD3 for onset ASD remain unexplored. Here, using male knock-out (CSMD3-/-) mice, we found that genetic deletion produced core autistic-like symptoms (social interaction deficits, restricted interests, repetitive stereotyped behaviors) motor dysfunction indicating can...
Minocycline has been demonstrated to exert neuroprotective effects in various experimental models. In the present study, we investigated mechanisms underlying protective of minocycline on cell injury induced by inhalation anesthetic, sevoflurane. our vivo experiments using rats, attenuated sevoflurane-induced neuronal degeneration and apoptosis rat hippocampus, this effect was associated with minocycline-mediated suppression oxidative stress hippocampus. vitro experiments, inhibited...
Backgrund/Aims: To investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR) on postoperative cognitive dysfunction (POCD) and intestinal injury induced by cardiopulmonary bypass (CPB) its relationship with Th17 response in order to provide a theoretical basis for organ protection targeted drug therapy during perioperative period. Methods: Sprague-Dawley rat models CPB were established. Rat brain injuries observed after using hematoxylin eosin staining. Cell...
hSNF2H partners with Rsf-1 to compose the Rsf complex regulate gene expression. Recent studies indicated that was overexpressed in several human cancers. However, its expression pattern and biological mechanism glioma remain unexplored. In this study, we found 32 % of specimens. overexpression correlated advanced tumor grade (p = 0.0338) positivity tissues 0.016). Small interfering RNA (siRNA) knockdown performed A172 U87 cell lines. MTT, colony formation assay, cycle analysis showed...
Introduction:The laryngeal mask airway (LMA)-Supreme is a disposable double-lumen that widely used in clinical practice.However, its use obese children has not been evaluated.The aim of this study was to determine whether the LMA-Supreme could perform equally as well endotracheal intubation having minor surgical procedure.Material and methods: After ethical board approval, 100 male receiving non-emergent appendectomy for chronic appendicitis or surgery correct concealed penis were randomly...