A5020782363- Osteoarthritis Treatment and Mechanisms
- Temporomandibular Joint Disorders
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Musculoskeletal synovial abnormalities and treatments
- Pharmacological Effects of Natural Compounds
- Bone Metabolism and Diseases
- Medicinal plant effects and applications
- Hepatitis C virus research
- Gas Sensing Nanomaterials and Sensors
- Hippo pathway signaling and YAP/TAZ
- Hepatitis Viruses Studies and Epidemiology
- Calpain Protease Function and Regulation
- Conducting polymers and applications
- Stress Responses and Cortisol
- Bone health and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Infrared Thermography in Medicine
- Laser Applications in Dentistry and Medicine
- Connective tissue disorders research
- PI3K/AKT/mTOR signaling in cancer
- Advanced Sensor and Energy Harvesting Materials
- interferon and immune responses
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Hepatitis B Virus Studies
Peking University
2019-2025
National Clinical Research Center for Digestive Diseases
2020-2025
Stomatology Hospital
2020-2025
King University
2021-2024
Zhengzhou University
2023
Pain and Headache Center
2022
Pressure and temperature are two important indicators for human skin perception. Electronic (E-skin) that mimics within one single flexible sensor is beneficial detecting differentiating pressure showing immunity from tensile strain disruptions. However, few studies have simultaneously realized these conditions. Herein, a strain-suppressed pressure–temperature dual-modal based on conductive microstructured metal–organic framework (MOF) films was reported mainly prepared by in situ growing...
Early-stage temporomandibular joint osteoarthritis (TMJOA) is characterized by excessive subchondral bone loss. Emerging evidence suggests that TMJ disc displacement involved, but the pathogenic mechanism remains unclear. Here, we established a rat model of TMJOA simulated with capacitance-based force-sensing system to directly measure articular surface pressure in vivo. Micro-CT, histological staining, immunofluorescence IHC and Western blot were used assess pathological changes underlying...
Abstract Background Degenerative joint disease (DJD) of the temporomandibular joints (TMJs) in adolescents and young adults is closely associated with disc displacement without reduction (DDw/oR). Objective This study aimed to determine pathogenesis early‐stage TMJ DJD induced by DDw/oR. Methods 31 female subjects aged 12‐30 years were enrolled, comprising 12 patients DDw/oR DJD, 13 6 healthy volunteers. The synovial fluid samples screened for 27 inflammatory‐related cytokines using multiple...
Abstract Neuropathic pain is a pervasive medical challenge currently lacking effective treatment options. Molecular changes at the site of peripheral nerve injury contribute to both and central sensitization, critical components neuropathic pain. This study explores role G-protein-coupled bile acid receptor (GPBAR1 or TGR5) in mechanisms underlying induced by partial sciatic ligation male mice. TGR5 was upregulated injured predominantly colocalized with macrophages. Perisciatic...
This study aimed to investigate the role and mechanism of Akt2 pathway in different stages anterior disc displacement (ADD)-induced temporomandibular joint osteoarthritis (TMJOA). A rat model for TMJOA that simulates was established. For inhibit expression subchondral bone, rats were intravenously injected with adeno-associated virus carrying shRNA at a titer 1 × 1012 transducing units/mL 10 days before ADD or sham operations. The euthanized evaluated 8 weeks after surgery, as these time...
Currently, there is a lack of effective therapy for chronic pain. Increasing evidence has shown that chemokines and their correlative receptors involved in the neuron-glial cell cross-talk could contribute to pathogenesis neuropathic Our previous studies suggested CXCR3 expression was elevated spinal dorsal horn after nerve injury.In this study, we aimed explore role signalling pain modulation.Reverse transcription quantitative PCR Western blotting were used measure its ligands cord...
<title>Abstract</title> Neuropathic pain is a pervasive medical challenge that currently lacks effective treatment solutions. Molecular changes occurring at the site of peripheral nerve damage contribute to development and central sensitization, which are critical components neuropathic pain. This study aimed investigate role G protein-coupled bile acid receptor (GPBAR1, also known as TGR5) in mechanisms underlying induced by partial sciatic ligation (pSNL) male mice. TGR5 was upregulated...
Background: Early-stage osteoarthritis (OA) is characterized by articular subchondral bone resorption and emerging evidence suggests that mechanical overloading likely involved. Here, we identified whether why could trigger in early-stage OA.Methods: A new monitoring system for real-time pressure measurement situ vivo a numerically controlled loading device tissue pressurized culture vitro were developed. Micro-CT was used to analyze the alterations of microarchitecture TRAP staining...