A5046378138- Pain Mechanisms and Treatments
- Acupuncture Treatment Research Studies
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
- Botulinum Toxin and Related Neurological Disorders
- Neuroscience and Neural Engineering
- Healthcare and Venom Research
- Stress Responses and Cortisol
- Ion Channels and Receptors
- Neurotransmitter Receptor Influence on Behavior
- Musculoskeletal pain and rehabilitation
- Nerve injury and regeneration
- Sperm and Testicular Function
- Memory and Neural Mechanisms
- Reproductive Biology and Fertility
- Parkinson's Disease Mechanisms and Treatments
- Pain Management and Placebo Effect
- Neural dynamics and brain function
- Pharmacological Receptor Mechanisms and Effects
- Neuroendocrine regulation and behavior
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
National Health and Family Planning Commission
2016-2025
Peking University
2016-2025
Henan Psychiatric Hospital
2017-2024
Xinxiang Medical University
2017-2024
King University
2024
Ministry of Education of the People's Republic of China
2008-2022
Peking University Third Hospital
2017
Zero to Three
2006
Sanford Burnham Prebys Medical Discovery Institute
2006
University of Florida
2005
Background: The present study aims to investigate the role of transient receptor potential vanilloid 1 (TRPV1) in dorsal root ganglion (DRG) neurons chronic pain including thermal hyperalgesia and mechanical allodynia. Chronic inflammatory nociception rats was produced by intraplantar injection complete Freund's adjuvant (CFA) data collected until day 28 following injection. Results: Thermal evident from with peak at 7, while allodynia persisted 14 greatest 7. Intrathecal administration AMG...
In Brief Primary and metastatic cancers that affect bone are frequently associated with severe intractable pain. The mechanisms underlying the pathogenesis of cancer pain still remain largely unknown. Previously, we have reported sensitization primary sensory dorsal root ganglion (DRG) neurons contributes to in rats. addition, numerous preclinical clinical studies revealed pathological roles interleukin-6 (IL-6) inflammatory neuropathic hyperalgesia. this study, investigated role IL-6...
Little is known about the efficacy of deep brain stimulation (DBS) as an effective treatment for Parkinson's Disease (PD) because lack multichannel neural electrical and chemical detection techniques at cellular level. In this study, a 7-mm-long 250-μm-wide microelectrode array (MEA) was fabricated to provide real-time monitoring dopamine (DA) concentration spike firings in caudate putamen (CPU) rats with PD. Platinumn nanoparticles reduced graphene oxide nanocomposites (Pt/rGO) were...
Abstract Introduction Painful diabetic neuropathy (PDN) is a common complication of diabetes. Previous studies have implicated that mitochondrial dysfunction plays role in the development PDN, but its pathogenesis and mechanism not been fully investigated. Methods In this study, we used high‐fat diet/low‐dose streptozotocin‐induced rats as model type 2 diabetes mellitus. Behavioral testing, whole‐cell patch‐clamp recordings dorsal root ganglion (DRG) neurons, complex sensory nerve conduction...
Peripheral nerve injury causes neuropathic pain including mechanical allodynia and thermal hyperalgesia due to central peripheral sensitization. Spontaneous ectopic discharges derived from dorsal root ganglion (DRG) neurons the sites of are a key factor in initiation this Numerous studies have focused primarily on DRG neurons; however, injured axons themselves likely play an equally important role. Previous rats with spinal ligation (SNL) showed that hyperpolarization-activated cyclic...
Summary Suppression of KCNQ/M channels in dorsal root ganglia neurons is associated with neuronal hyperexcitability and cancer-induced bone pain rats. Bone cancer has a strong impact on the quality life patients, but difficult to treat. Better understanding pathogenic mechanisms underlying will likely lead development more effective treatments. In present study, we investigated whether inhibition contributed primary sensory pathogenesis pain. By using rat model based intratibial injection...
Despite high prevalence of anxiety accompanying with chronic pain, the mechanisms underlying pain-related are largely unknown. With its well-documented role in pain and emotion processing, amygdala may act as a key player pathogenesis neuropathic anxiety. Pain-related plasticity sensitization CeA (central nucleus amygdala) neurons have been shown several models pain. In addition, firing pattern spike output can powerfully affect functional brain nucleus, GABAergic crucial modulation neuronal...
Abstract Exacerbation of pain by chronic stress and comorbidity with stress-related psychiatric disorders, including anxiety depression, represent significant clinical challenges. However, the underlying mechanisms still remain unclear. Here, we investigated whether forced swim (CFSS)–induced exacerbation neuropathic is mediated integration stress-affect–related information nociceptive in central nucleus amygdala (CeA). We first demonstrated that CFSS indeed produces both depressive-like...
Neural stem cell (NSC) transplantation is one of the most promising therapeutic strategies for neurodegenerative diseases. However, slow spontaneous differentiation NSCs often hampers their application in neural repair. Although some biological growth factors accelerate NSCs, high cost, short half-life, and unpredictable behavior vivo, as well complexity operation, hinder clinical use. In this study, it demonstrated that hydroxyapatite (HAp), main component bone, form nanorods, can regulate...
Background: Primary and metastatic cancers that affect bone are frequently associated with severe intractable pain. The mechanisms underlying the development of cancer pain largely unknown. aim this study was to determine whether enhanced excitability primary sensory neurons contributed peripheral sensitization tumor-induced hyperalgesia during condition. In study, using techniques whole-cell patch-clamp recording immunofluorescent staining, single-cell reverse-transcriptase PCR behavioral...
Abstract Background Up‐regulation of transient receptor potential vanilloid subfamily, member 1 ( TRPV1 ) is associated with the development and maintenance cancer pain. The present study aimed to investigate electrophysiological function up‐regulated regulatory effects insulin‐like growth factor‐1 IGF ‐1) on expression in peripheral nerves a rat model bone Methods A pain rats was established by injecting MRMT ‐1 (rat mammary gland carcinoma cells) breast cells into tibia cavity. Thermal...
Rationale: Idiopathic asthenozoospermia (iAZS) is one of the major causes male infertility and has no effective therapeutic treatment. Understanding potential mechanisms that cause it may be helpful in seeking novel targets treatment strategies for overcoming problem low sperm motility iAZS individuals. Methods: Computer-assisted semen analysis (CASA) was utilized to assess motility. RT-qPCR, Western blot, immunofluorescence staining, calcium imaging were performed examine expression...
Acupuncture and electro-acupuncture (EA) are now widely used to treat disorders like pain. We others have shown previously that current frequency, intensity treatment duration all significantly influence the anti-nociceptive effects of EA. There is evidence stimulating sites also affect antinociception, with EA applied ipsilaterally pain site being more effective under some states but contralateral others. It was recently reported local adenosine A1 receptors were responsible for ipsilateral...
Primary and metastatic cancers that affect bone are frequently associated with severe intractable pain. The mechanisms underlying the development of cancer pain largely unknown. In this study, we first demonstrated a functional upregulation P2X3 receptors in dorsal root ganglion (DRG) neurons is closely neuronal hyperexcitability cancer-induced MRMT-1 tumor cell-inoculated rats. Second, revealed visinin-like protein 1 (VILIP-1), member proteins belong to family calcium sensor responsible for...