A5040147974- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Irrigation Practices and Water Management
- Electrochemical Analysis and Applications
- Memory and Neural Mechanisms
- Electrochemical sensors and biosensors
- Parkinson's Disease Mechanisms and Treatments
- Plant Physiology and Cultivation Studies
- Plant Water Relations and Carbon Dynamics
- Advanced Memory and Neural Computing
- Advanced biosensing and bioanalysis techniques
- Environmental and Agricultural Sciences
- Horticultural and Viticultural Research
- Plant responses to water stress
- Conducting polymers and applications
- Pluripotent Stem Cells Research
- Crop Yield and Soil Fertility
- Molecular Communication and Nanonetworks
- Analog and Mixed-Signal Circuit Design
- Heart Rate Variability and Autonomic Control
- Glycogen Storage Diseases and Myoclonus
State Key Laboratory of Transducer Technology
2013-2025
Chinese Academy of Sciences
2011-2025
University of Chinese Academy of Sciences
2016-2025
Aerospace Information Research Institute
2020-2025
Institute of Semiconductors
2022
Institute of Electronics
2010-2019
Institute of Chemical Industry of Forest Products
2015
Northwest A&F University
2007-2009
Ministry of Education of the People's Republic of China
2007
University of Kang Ning
2004
Little is known about the efficacy of deep brain stimulation (DBS) as an effective treatment for Parkinson's Disease (PD) because lack multichannel neural electrical and chemical detection techniques at cellular level. In this study, a 7-mm-long 250-μm-wide microelectrode array (MEA) was fabricated to provide real-time monitoring dopamine (DA) concentration spike firings in caudate putamen (CPU) rats with PD. Platinumn nanoparticles reduced graphene oxide nanocomposites (Pt/rGO) were...
Abstract Parkinson’s disease (PD) is characterized by a progressive degeneration of nigrostriatal dopaminergic neurons. The precise mechanisms are still unknown. Since the neuronal communications inherently electrical and chemical in nature, dual-mode detection PD-related neuroelectrical neurochemical information essential for PD research. Subthalamic nucleus (STN) high-frequency stimulation (HFS) can improve most symptoms patients decrease dosage antiparkinsonian drugs. mechanism STN-HFS...
Accurate detection of the degree isoflurane anesthesia during a surgery is important to avoid risk overdose timely. To address this challenge, four-shank implantable microelectrode array (MEA) was fabricated for synchronous real-time dual-mode signals [electrophysiological signal and dopamine (DA) concentration] in rat striatum. The SWCNTs/PEDOT:PSS nanocomposites were modified onto MEAs, which significantly improved electrical electrochemical performances MEAs. performance MEAs with low...
Epilepsy detection and focus location are urgent issues that need to be solved in epilepsy research. A cortex conformable fine spatial accuracy electrocorticogram (ECoG) sensor array, especially for real-time of multicortical functional regions delineating epileptic remains a challenge. Here, we fabricated polydimethylsiloxane (PDMS)–parylene hybrid, flexible micro-ECoG electrode array. The multiwalled carbon nanotubes (MWCNTs)/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)...
17β-Estradiol (E2) is a critical sex steroid hormone, which has significant effects on the endocrine systems of both humans and animals. E2 also believed to play neurotrophic neuroprotective roles in brain. Biosensors present powerful tool detect because their small, efficient, flexible design. Furthermore, can quickly accurately obtain detection results with only small sampling amount, greatly meets environment, food safety, medicine human body. This review focuses previous studies...
Abstract Hippocampal CA1 neurons show intense firing at specific spatial locations, modulated by isolated landmarks. However, the impact of real‐world scene transitions on neuronal activity remains unclear. Moreover, long‐term neural recording during movement challenges device stability. Conventional rigid‐based electrodes cause inflammatory responses, restricting durations. Inspired jellyfish tentacles, multi‐conductive layer ultra‐flexible microelectrode arrays (MEAs) are developed. The...
The medial amygdala (MA) plays an important role in the innate fear circuit. However, electrophysiological mechanism of MA for processing needs to be further explored. In this study, we fabricated microelectrode arrays (MEAs) with detecting sites arranged match location and shape mice detected electrophysiology freely behaving under 2-methyl-2-thiazoline (2MT)-induced fear. detection performance MEA is improved by modifying metal nanoparticles conductive polymers (PtNPs/PEDOT:PSS). After...
Due to their compact size and exceptional sensitivity at room temperature, magnetoresistance (MR) sensors have garnered considerable interest in numerous fields, particularly the detection of weak magnetic signals biological systems. The "magnetrodes", integrating MR with needle-shaped Si-based substrates, are designed be inserted into brain for local field detection. Although recent research has predominantly focused on giant (GMR) sensors, tunnel (TMR) exhibit a significantly higher...
The globus pallidus internus (GPi) was considered a common target for stimulation in Parkinson’s disease (PD). Located deep the brain and of small size, pinpointing it during surgery is challenging. Multi-channel microelectrode arrays (MEAs) can provide micrometer-level precision functional localization, which maximize surgical outcome. In this paper, 64-channel MEA modified by platinum nanoparticles with detection site impedance 61.1 kΩ designed prepared, multiple channels could be...
Precise assessment of wakefulness states during sevoflurane anesthesia and timely arousal are paramount importance to refine the control anesthesia. To tackle this issue, a bidirectional implantable microelectrode array (MEA) is designed with capability detect electrophysiological signal perform in situ deep brain stimulation (DBS) within dorsomedial hypothalamus (DMH) mice. The MEA, modified platinum nanoparticles/IrOx nanocomposites, exhibits exceptional characteristics, featuring low...
Wireless microsystems for neural signal recording have emerged as a solution to overcome the limitations of tethered systems, which restrict mobility subjects and introduce noise interference. However, existing often face data throughput, processing, long-distance wireless transmission challenges. This study presents high-performance microsystem capable 32-channel, 30 kHz real-time recording, featuring Field Programmable Gate Array (FPGA)-based processing reduce load. The is integrated with...
Grid cells with stable hexagonal firing patterns in the medial entorhinal cortex (MEC) carry vital function of serving as a metric for surrounding environment. Whether this mechanism processes only spatial information or involves nonspatial remains elusive. Here, we fabricated an MEC-shaped microelectrode array (MEA) to detect variation neural spikes and local field potentials MEC when rats forage square enclosure planar, three-dimensional object social landmarks sequence. The results showed...