A5100665198- Renal Diseases and Glomerulopathies
- Dialysis and Renal Disease Management
- Barrier Structure and Function Studies
- Vasculitis and related conditions
- Lepidoptera: Biology and Taxonomy
- Gut microbiota and health
- Renin-Angiotensin System Studies
- Celiac Disease Research and Management
- Gout, Hyperuricemia, Uric Acid
- Vagus Nerve Stimulation Research
- Genetic and rare skin diseases.
- Intensive Care Unit Cognitive Disorders
- Genetic diversity and population structure
- Folate and B Vitamins Research
- Chronic Kidney Disease and Diabetes
- Urticaria and Related Conditions
- Cancer, Stress, Anesthesia, and Immune Response
- Complement system in diseases
- Iron Metabolism and Disorders
- Childhood Cancer Survivors' Quality of Life
- Autoimmune Bullous Skin Diseases
- Cerebral Palsy and Movement Disorders
- Nicotinic Acetylcholine Receptors Study
- Reproductive System and Pregnancy
- Lymphatic Disorders and Treatments
Beijing Tongren Hospital
2024
Capital Medical University
2013-2024
Beijing Children’s Hospital
2012-2023
Ministry of Education of the People's Republic of China
2019-2021
Northwest A&F University
2020-2021
National Center for Women and Children’s Health, China CDC
2019
Beijing Center for Disease Prevention and Control
2019
General Hospital of Shenyang Military Region
2017-2018
Beijing Tian Tan Hospital
2013
To understand mitogenome characteristics and reveal phylogenetic relationships of the genus Ostrinia, including several notorious pests great importance for crops, we sequenced complete mitogenomes four species: Ostrinia furnacalis (Guenée, 1854), nubilalis (Hübner, 1796), scapulalis (Walker, 1859) zealis 1854). Results indicate that mitogenomes—O. furnacalis, O. nubilalis, scapulalis, zealis—are 15,245, 15,248, 15,311, 15,208 bp in size, respectively. All are comprised 37 encoded genes a...
IgA nephropathy (IgAN) is one of the most common glomerular diseases leading to end-stage renal failure. Elevation aberrantly glycosylated IgA1 a key feature it. The expression specific molecular chaperone core1ß1, 3galactosyl transferase (Cosmc) known be reduced in IgAN. We aimed investigate whether methylation CpG islands Cosmc gene promoter region could act as possible mechanism responsible for down-regulation and related higher secretion IgA1in lymphocytes from children with nephropathy....
Background: B-cell-deleted therapy has been successfully used for children with idiopathic nephrotic syndrome (INS), suggesting that B cells may be involved in the pathogenesis of INS. are a heterogenous population comprised subpopulations distinguished by their phenotypes. However, few studies have focused on alteration B-cell homeostasis Methods: We measured levels subsets blood 87 INS via flow cytometry, prior to treatment steroids. patients were divided into steroid-sensitive (SSNS) and...
Backgrund/Aims: To investigate the effects of activated α7 nicotinic acetylcholine receptor (α7nAChR) on postoperative cognitive dysfunction (POCD) and intestinal injury induced by cardiopulmonary bypass (CPB) its relationship with Th17 response in order to provide a theoretical basis for organ protection targeted drug therapy during perioperative period. Methods: Sprague-Dawley rat models CPB were established. Rat brain injuries observed after using hematoxylin eosin staining. Cell...
Objective . To investigate the effects of TLR3 and TLR9 signaling pathway on brain injury during CPB in rats pretreated with sevoflurane its possible molecular mechanism. Methods SD were randomly assigned to sham group, Sev group. Brain tissue was obtained at before (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>T</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle="italic">0</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>), for 30...
The aim of the present study was to investigate effect microRNAs (miRNAs) on expression level core1β3‑galactosyltransferase‑specific molecular chaperone (COSMC) in immunoglobulin A nephropathy (IgAN). miRNA levels were determined pediatric patients with IgAN (IgAN group), other renal diseases (control group) and healthy pediatrics group). target miRNAs COSMC investigated study. Western blot analysis performed examine effects levels. In addition, galactose‑deficient IgA1 (Gd‑IgA1) detected...
The complete mitochondrial genome of Ostrinia kasmirica (Moore, 1888) was sequenced in this study. circular mitogenome is 15,214 bp length, containing 37 typical encoded genes and a non-coding control region. gene organization nucleotide composition are similar to those most other species. All protein-coding (PCGs) initiate with ATN terminate TAN, except cox1 starts CGA cox1, cox2, nad5 an incomplete codon T. region 308 contains three conserved features including the motif 'TTAGA' preceded...
To evaluate the common Traditional Chinese Medicine (TCM) syndromes and analyze their relationship to clinical pathological manifestations in children with IgA nephropathy. Forty five diagnosed as having primary nephropathy by renal biopsy for first time were enrolled this trial, TCM evaluated distribution of was observed. All sick growed? according damages, differences compared between groups. The 5 symptoms cold, hyperhidrosis, red dry throat, dark yellow urine lassitude. In acute...
A 5-year-old boy was found to have "leukocoria" and referred for evaluation. Slit-lamp photography (A, B) showed multiple pearl-like, white cysts as "pseudohypopyon" in the anterior chamber with associated neovascularization. Ultrasound biomicroscopy (C) confirmed a medium reflective solid iridociliary mass intratumoral cystic areas that proved on enucleation be nonteratoid malignant medulloepithelioma (D, hematoxylin eosin ×40). The patient had no signs of tumor recurrence or metastases...
对首都医科大学附属北京儿童医院肾脏科收治的1例肾病综合征合并乳糜胸患儿的临床资料进行回顾性分析。患儿，女，13岁，因肾病综合征入院，并胸腔积液，胸腔穿刺液为乳糜样，实验室检查确诊为真性乳糜胸，淋巴管造影提示胸导管出口梗阻。肾活检为肾小球微小病变。经原发病治疗，早期积极抗凝，对症等综合治疗后，患儿预后良好。提示乳糜胸是儿童肾病综合征罕见并发症，在无禁忌证的情况下尽早胸部增强CT及血管超声寻找血栓证据，同时建议行淋巴管造影评估有无淋巴管畸形存在。治疗方面以控制原发病，积极抗凝及对症治疗为主，预后良好。
Objective To study the patients' clinical characteristics and prognosis when only C3 deposition exists in endocapillary proliferative glomerulonephritis try to understand deeply role of kidney damage deeply. Methods The patients who were diagnosed with but had deposited immunofluorescence (to avoid false positive, C3≥2+ was included) selected from Beijing Children's Hospital Affiliated Capital Medical University during November 2010 October 2014.Their manifestations, laboratory...
Objective: To analyze the clinical characteristics and risk factors of protein energy wasting (PEW) in children with chronic kidney disease (CKD). Methods: Clinical data 231 hospitalized Beijing Children's Hospital affiliated to Capital Medical University from January 2018 2023 were retrospectively analyzed explore incidence PEW. According diagnostic criteria CKDPEW, they divided into a CKDPEW group non PEW group. The comparison between groups was performed by independent-sample t test...
Abstract Background In children with CKD, Protein Energy Wasting (PEW) is common, which affects the outcome of and an important cause poor prognosis. We are aiming to explore pathogenesis muscle wasting in CKD-PEW children. Methods Blood samples 32 diagnosed chronic kidney disease (CKD) protein energy our hospital from January 2016 June 2021 were collected. RNA sequencing bioinformatics analysis performed. Results Based on GO (Gene Ontology) functional enrichment analysis, KEGG (Kyoto...