A5102739346- Gestational Diabetes Research and Management
- Coronary Interventions and Diagnostics
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cardiac Imaging and Diagnostics
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Pain Mechanisms and Treatments
- Gout, Hyperuricemia, Uric Acid
- Advanced Glycation End Products research
- Cardiovascular Health and Disease Prevention
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Natural Antidiabetic Agents Studies
- Emergency and Acute Care Studies
- Inflammation biomarkers and pathways
Yixing People's Hospital
2024
Jiangsu University
2021-2024
Harbin University of Commerce
2024
International Peace Maternity & Child Health Hospital
2017-2023
Shanghai Jiao Tong University
2013-2023
University of South China
2023
Ruijin Hospital
2013-2022
Jiangsu Shengze Hospital
2020-2022
Nanjing Medical University
2015-2022
Zhejiang University
2021
Polygonatum sibiricum polysaccharide (PSP) was extracted and purified from raw material obtained P. sibiricum. The structural features of PSP were investigated by Congo red, circular dichroism spectrum, high-performance gel permeation chromatography, scanning electron microscope, atomic force ultraviolet spectroscopy, Fourier transform infrared spectroscopy analysis. In vitro simulations conducted to investigate the kinetics enzyme inhibition. Moreover, a type II diabetes mouse model (T2DM)...
Abstract Background Non-enzymatic glycation increases hemoglobin-oxygen affinity and reduces oxygen delivery to tissues by altering the structure function of hemoglobin. Objectives We investigated whether an elevated blood concentration glycosylated hemoglobin (HbA1c) could induce falsely high pulse oximeter saturation (SpO 2 ) in type diabetic patients during mechanical ventilation or therapy. Methods Arterial (SaO partial pressure (PO were determined with simultaneous monitoring SpO 261...
IgA nephropathy (IgAN) is one of the most common glomerular diseases leading to end-stage renal failure. Elevation aberrantly glycosylated IgA1 a key feature it. The expression specific molecular chaperone core1ß1, 3galactosyl transferase (Cosmc) known be reduced in IgAN. We aimed investigate whether methylation CpG islands Cosmc gene promoter region could act as possible mechanism responsible for down-regulation and related higher secretion IgA1in lymphocytes from children with nephropathy....
Quantification of potential consequences associated with the use epidural analgesia during labor could help to improve safety and quality delivery care for parturient women.To evaluate association between neonatal infection in a large cohort women.This propensity score-matched study was conducted at university-affiliated hospital Shanghai, China. Women full-term pregnancy undergoing vaginal January 2013 October 2018 were included study. Parturient women who parous, experiencing premature...
Abstract Aims and objectives This study aimed at evaluating the accuracy of visual estimated blood loss in postpartum haemorrhage by midwives nurses, as well exploring its influencing factors. Background Timely recognition is critical saving maternal lives. Yet nurses can barely distinguish whether has reached a life‐threatening amount without precise measurement. Understanding their ability to accurately estimate factors help improve this with effective measures. Design research was...
Abstract This study aimed to investigate the potential associations between carotid intima-media thickness and cognitive impairment among patients with acute ischemic stroke identify clinical implications. We measured (IMT) performed Mini-Mental State Examination (MMSE) upon admission of 1,826 patients. The association IMT evaluated by MMSE was assessed a multivariate regression analysis. Other variables interest were also assessed. After adjusting for confounders, participants in highest...
Studies have shown that the effects of maternal nutrition exposure during gestation influence metabolic risk in early life through an epigenetic mechanism. Low glycaemic index (GI) diets benefit both and neonatal gestational outcomes. We hypothesize dietary GI or load (GL) changes pregnancy impact placental DNA methylation, especially insulin resistance-related genes. From a clinical trial overweight pregnant women, 12 subjects who successfully reduced their another whose increased despite...
Our previous study showed there was a gender difference in plasma lactate concentrations subjects with type 2 diabetes. This investigated the effect of sex hormone levels on lactic acid (LA) diabetes and without metformin therapy.Fasting whole blood specimens 392 patients treated (n=199) or not (n=193) were collected. LA measured an enzyme-electrode assay. Levels hormones, including testosterone (T) estradiol (E(2)), chemiluminescence microparticle immunoassay. Spearman's Pearson's...
Objective To evaluate whether glycation of high-density lipoprotein (HDL) increases cardiovascular risk in patients with type 2 diabetes mellitus by altering its anti-atherogenic property. Data sources cited this review were obtained mainly from Pubmed and Medline English 2000 to 2013, keywords “glycation”, “HDL”, “atherosclerosis”. Study selection Articles regarding HDL role atherogenesis both humans experimental animal models identified, retrieved reviewed. Results Glycation alters the...
Complement factor H (CFH) has been found to be associated with insulin resistance. This study assessed the correlation between CFH and other clinical parameters, determined whether played a role in gestational diabetes mellitus (GDM) adverse pregnancy outcomes.A total of 397 pregnant women were included for analysis this nested case-control study. Clinical parameters serum collected within 11-17th age at first prenatal visit. At 24-28 weeks gestation, 75 g oral glucose tolerance test was...
This study was to assess the alteration of circulating complement factor Ba (CFBa) within 11 17 weeks gestation and its association with subsequent gestational diabetes mellitus (GDM) delivery outcome.Biochemical parameters blood samples were collected from 399 pregnant women gestation. At 24 28 gestation, all participants underwent 75-g oral glucose tolerance test assigned GDM group (n = 80) normal control 319). Perinatal data after delivery. A propensity score-matched (PSM) analysis...
With the rising costs for knee arthroplasty, therapies that allow patients to avoid or delay surgery following osteoarthritis (KOA) may help in reducing overall health care costs. Multiple intraarticular hyaluronic acid (HA) products are available on market, varying by formulation, molecular weight, and number of injections, but clinical economic benefits differ product.
Introduction Perioperative infections may be considered predictors of caesarean scar defect (CSD), and multidose antibiotics have a protective effect against CSD. However, the ability adjunctive azithromycin combined with cephalosporin to reduce prevalence CSD remains unclear. The planned study aims clarify assess effectiveness prophylaxis for Methods analysis This is double-blind, parallel-control randomised clinical trial that will carried out at International Peace Maternity Child Health...
<b><i>Objective:</i></b> To investigate the expression of T-cell immunoglobulin and mucin domain 3 (TIM-3) on peripheral T cells cervical carcinoma patients. <b><i>Methods:</i></b> Peripheral blood samples from 15 high-grade squamous intraepithelial lesion (HSIL) patients, 24 21 healthy controls were collected. TIM-3 expressions surface CD4+ CD8+ analyzed with flow cytometry. <b><i>Results:</i></b> There was...
Abstract Background: To assess the prognostic role of coronary collaterals in patients with type 2 diabetes mellitus (T2DM) after successful percutaneous intervention (PCI) for chronic total occlusion (CTO). Methods: Coronary collateralization was graded according to Rentrop scoring system 198 diabetic and 335 non-diabetics stable angina undergoing PCI at least one CTO lesion. Left ventricular ejection fraction (LVEF) determined major adverse cardio-cerebral events (MACCE) were recorded...
<sec> <title>BACKGROUND</title> Postpartum Hemorrhage has been recognized as the most fatal factor in maternal death. Yet midwives can barely distinguish whether blood loss reached a life-threatening amount without precise measurement, particularly during slow hemorrhage. Also, understaffed mainland China adds to difficulty of timely accurate measurement loss. </sec> <title>OBJECTIVE</title> To evaluate accuracy visual estimated postpartum hemorrhage by clinical midwives, well...