A5100735760- Diet and metabolism studies
- Advanced Chemical Sensor Technologies
- Viral Infections and Vectors
- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Protein Hydrolysis and Bioactive Peptides
- Protein Interaction Studies and Fluorescence Analysis
- Echinoderm biology and ecology
- Metal complexes synthesis and properties
- Mosquito-borne diseases and control
- Glycosylation and Glycoproteins Research
- Wastewater Treatment and Nitrogen Removal
- Osteoarthritis Treatment and Mechanisms
- Viral Infections and Outbreaks Research
- Proteoglycans and glycosaminoglycans research
- Enzyme Catalysis and Immobilization
- Neurogenesis and neuroplasticity mechanisms
- Odor and Emission Control Technologies
- Fatty Acid Research and Health
- Advanced oxidation water treatment
- Immune Cell Function and Interaction
- Bacteriophages and microbial interactions
- Proteins in Food Systems
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Air Quality Monitoring and Forecasting
University of Shanghai for Science and Technology
2024-2025
Liaocheng University
2018-2024
Qilu University of Technology
2024
Clinical Research Center Kiel
2015-2022
Wangjing Hospital of China Academy of Chinese Medical Sciences
2022
Academy of Military Medical Sciences
2010-2021
Chinese Medical Association
2020
Tongji University
2019
Kiel University
2015-2019
Xuzhou Medical College
2015
Background Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute independently or together to the boundary lubrication of articular joints that is provided by synovial fluid (SF). Our study first reporting quantitative data about molecular weight (MW) forms HA, PLs in SF from cohorts healthy donors, patients with early (eOA)- late (lOA)-stage osteoarthritis (OA), active rheumatoid arthritis (RA). Methods We used human unaffected controls, eOA, lOA, RA. HA lubricin levels...
Multiple sclerosis (MS) is an autoimmune disorder characterized by demyelination and neurodegeneration in the central nervous system (CNS); severe symptoms lead MS patients to use complementary treatments. Ketogenic diet (KD) shows wide neuroprotective effects, but precise mechanisms underlying therapeutic activity of KD are unclear. The present study established a continuous 24 days experimental encephalomyelitis (EAE) mouse model with or without KD. changes motor function, pathological...
Many advanced cancers are characterized by metabolic disorders. A dietary therapeutic strategy was proposed to inhibit tumor growth through administration of low-carbohydrate, average-protein, and high-fat diet, which is also known as ketogenic diet (KD). In vivo antitumor efficacy KD on transplanted CT26+ cells in BALB/c mice investigated. The results showed that the group had significantly higher blood β-hydroxybutyrate lower glucose levels when compared with normal group. Meanwhile,...
Abstract Background The aim of the present cross-sectional study was to assess possible associations between osteopontin (OPN), and thrombin-cleaved (N-half) OPN, nephropathy coronary artery disease (CAD) in patients with type 2 diabetes mellitus (T2DM). Methods Plasma levels N-half high-sensitivity C-reactive protein (hsCRP) were determined 301 diabetic (n = 226) or without 75) angiographically documented CAD (luminal diameter narrowing >50%), as well 75 non-diabetic controls normal...
Abstract
Degenerative diseases, such as Alzheimer's and prion well type II diabetes, have a pathogenesis associated with protein misfolding, which routes amyloid formation. Recent strategies for designing small-molecule polypeptide antiamyloid inhibitors are mainly based on mature fibril structures containing cross β-sheet structures. In the present study, we tackled hypothesis that rational design of agents can target native proteins might offer advantageous prospect to effective therapeutics....
Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS). Recently, ketogenic diet (KD) supplementation has attracted great interest. Therefore, we established cuprizone (CPZ)-induced demyelination mouse model to investigate possible neuroprotective effect KD on hippocampus mice. We found that significantly elevated level serum β-hydroxybutyric acid, improved behavioral and motor abnormalities, impaired spatial learning memory CPZ-induced...
Misfolding proteins could form oligomers or amyloid fibers, which can cause a variety of amyloid-associated diseases. Thus, the inhibition protein misfolding and fibrillation is promising way to prevent treat these Captopril (CAP) an angiotensin-converting enzyme inhibitor (ACEI) that widely used diseases such as hypertension heart failure. In this study, we found CAP inhibits human lysozyme (HL) through combination techniques biophysics biochemistry. The data obtained by thioflavin-T (ThT)...
Suppression of excessive microglial overactivation can prevent the progression multiple sclerosis (MS). Histone deacetylases 3 inhibitor (HDAC3i) has been demonstrated to exert anti-inflammatory effects by suppressing microglia (M1-liked) activation. Here, we demonstrate that RGFP966 (a selective HDAC3) protects white matter after cuprizone-induced demyelination, as shown reductions in neurological behavioral deficits and increases myelin basic protein. Moreover, this study, found caused a...
Multiple sclerosis (MS) is a chronic inflammatory and degenerative disease of central nervous system (CNS). Aging the most significant risk factor for progression MS. Dietary modulation (such as ketogenic diet) caloric restriction, can increase ketone bodies, especially β-hydroxybutyrate (BHB). Increased BHB has been reported to prevent or improve age-related disease. The present studies were performed understand therapeutic effect potential mechanisms exogenous in cuprizone (CPZ)-induced...
The negative ion air purifier (NIAP) has been used for capturing particulate matter. Nevertheless, the knowledge on its effectiveness in removing other pollutants such as ammonia gas remains limited. In this study, effect of an NIAP indoor removal was evaluated through a series experimental studies. applicability and different influencing, operating, environmental factors performance were firstly investigated by conducting experiments. Then, order to understand spatial distribution...
Phosphatidylserine (PS) is a major anionic phospholipid constituent of membrane bilayers, which specifically enriched in the cytoplasmic leaflet, has functions regulating intracellular signaling pathways neuronal survival and differentiation, acts as neurotransmitter to control activity neurons. Oil-in-water (O/W) emulsions could improve bio-availability PS. Thus, there high level interest PS emulsion because its purported health benefits. However, viscosity poor fluidity, it remains...
Ketogenic diet (KD) is defined as a high-fat, low-carbohydrate with appropriate amounts of protein, which has broad neuroprotective effects.
Osteoarthritis belongs to the most common joint diseases in humans and animals shows increased incidence older patients. The bioactivities of collagen hydrolysates, sulfated glucosamine a special fatty acid enriched dog-food were tested dog patient study 52 dogs as potential therapeutic treatment options early osteoarthritis. Biophysical, biochemical, cell biological molecular modeling methods support that these well-defined substances may act effective nutraceuticals. Importantly, applied...
Epigenetic regulation plays a critical role in controlling fungal secondary metabolism. Here, we report the pleiotropic effects of epigenetic regulator HdaA (histone deacetylase) on metabolite production and associated biosynthetic gene clusters (BGCs) expression plant endophytic fungus Penicillium chrysogenum Fes1701. Deletion hdaA strain Fes1701 induced significant change profile with emergence bioactive indole alkaloid meleagrin. Simultaneously, more meleagrin/roquefortine-related...