A5007492792- Pharmaceutical and Antibiotic Environmental Impacts
- Aquaculture disease management and microbiota
- Adipose Tissue and Metabolism
- Environmental Toxicology and Ecotoxicology
- Reproductive biology and impacts on aquatic species
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Advanced Glycation End Products research
- Adipokines, Inflammation, and Metabolic Diseases
- Environmental Chemistry and Analysis
- Inflammasome and immune disorders
- Proteins in Food Systems
- Gut microbiota and health
- Diet and metabolism studies
- Proteoglycans and glycosaminoglycans research
- Hydrogen's biological and therapeutic effects
- Botanical Research and Applications
- Advanced Biosensing Techniques and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Effects and risks of endocrine disrupting chemicals
- Geophysics and Gravity Measurements
- Analytical chemistry methods development
- Chromium effects and bioremediation
- Autophagy in Disease and Therapy
- Sirtuins and Resveratrol in Medicine
Xiamen University
2020-2025
GEOMAR Helmholtz Centre for Ocean Research Kiel
2025
Peking University
2017-2023
Beijing Meteorological Bureau
2023
China Medical University
2013-2021
Liaocheng University
2020
Sun Yat-sen University
2018-2020
Guangzhou Experimental Station
2018
Hainan Medical College Hospital
2017
First Hospital of China Medical University
2013-2017
Fluoroquinolones (FQs) and tetracyclines (TCs), the two β-diketone antibiotics (DKAs), are frequently detected pollutants in environment; however, little data available on their combined toxicity to zebrafish (Danio rerio). This study reports that toxicologic effects of DKA (FQs-TCs) exposure were comparable with or slightly less than those TCs alone, showing played a major role mixtures. The FQs, TCs, DKAs malformation rates dose dependent, EC50 values 481.3, 16.4, 135.1 mg/L, respectively....
Heparanase, a heparan sulfate (HS)–specific endoglycosidase, plays an important role in inflammation and mediates acute pulmonary renal injuries during sepsis. To explore its septic intestinal injury, non-anticoagulant heparanase inhibitor, N-desulfated/re- N-acetylated heparin (NAH), was administrated to mouse sepsis model induced by cecal ligation puncture (CLP). Immunohistochemical staining revealed massive shedding of HS from the mucosal surfaces after CLP, effective inhibition NAH...
Promoting the browning of white fat may be a potential means combating obesity. Therefore, in this study, we investigated effect resveratrol (RES) on body weight and high-fat diet (HFD)-induced obese mice associated mechanism vivo. Eight-week-old male were randomized to receive different treatments: (1), chow without any additional treatment (chow); (2), plus 0.4% (chow-RES); (3), HFD (HFD); (4), (HFD-RES). After 4 weeks feeding, 8-week-old recipient randomly allocated following (5),...
Phosphatidylserine (PS) is a major anionic phospholipid constituent of membrane bilayers, which specifically enriched in the cytoplasmic leaflet, has functions regulating intracellular signaling pathways neuronal survival and differentiation, acts as neurotransmitter to control activity neurons. Oil-in-water (O/W) emulsions could improve bio-availability PS. Thus, there high level interest PS emulsion because its purported health benefits. However, viscosity poor fluidity, it remains...
Ketogenic diet (KD) is defined as a high-fat, low-carbohydrate with appropriate amounts of protein, which has broad neuroprotective effects.
High mobility group box 1 (HMGB1) causes microvascular endothelial cell barrier dysfunction during acute lung injury (ALI) in sepsis, but the mechanisms have not been well understood. We studied roles of RAGE and Rho kinase (ROCK1) HMGB1-induced human pulmonary disruption. In present study, recombinant high (rhHMGB1) was used to stimulate cells (HPMECs). The (EC) permeability examined by detecting FITC-dextran flux. CCK-8 assay detect viability under rhHMGB1 treatments. expression related...
Browning of white adipose tissues (WAT) is recognized as a novel way to combat obesity and its related comorbidities. Thus, lot dietary agents contributing browning WAT have been identified.In this study, we try explore the mechanism induced by resveratrol (Res) in 3T3-L1 adipocytes.The levels cell viability lipid accumulation were evaluated under different concentrations Res. Cell signaling pathway analysis was performed investigate possible mechanisms effect Res cells.We found that brown...
Sepsis is the leading cause of death in intensive care units. MicroRNA-34a (miR-34a) involved sepsis progression, while its underlying mechanisms on sepsis-induced lung injury remain obscure. Oxidative stress, pyroptosis and inhibition autophagy can result organ injury. MiR-34a has been reported to regulate oxidative stress via inhibiting silent information regulator T1 (SIRT1) gene 4B (ATG4B) signaling. This study aimed at identifying function miR-34a inflammation, Male 8-week-old C57BL/6...
To investigate whether resveratrol could ameliorate the hepatic steatosis in high-fat diet (HFD) fed mice by modulating gut microbiota composition, fecal transplantation (FMT) was utilized this study. Our results showed that significantly ameliorated HFD mice, increased gene expression of fasting-induced adipose factor, and decreased lipogenesis-related genes proteins (SREBP-1, FAS ACC). In addition, reversed HFD-induced dysbiosis, with an increase relative abundance Bacteroidetes a decrease...
β-Diketone antibiotics (DKAs) can produce chronic toxicity in aquatic ecosystems due to their pseudo-persistent the environment. In this study, after long-term DKA exposure zebrafish (Danio rerio), 47 protein spots had greater than 2-fold differential expression as compared control; there were 26 positive proteins with 14 up-regulated and 12 down-regulated. The main functions of differentially expressed related signal transduction mechanisms cytoskeleton. Of target genes, 11 genes consistent...
Abstract The Multiband Ultraviolet Spectrum Imager (MUSI) is an optical remote sensing instrument scheduled to launch on the Fengyun‐4C meteorological satellite in 2024. MUSI designed measure airglow emissions between ∼120 and 160 nm above East Asia Pacific region from a geostationary orbit infer ionospheric parameters. Here we develop lookup‐table algorithm for retrieving peak electron density ( n m F 2 ) Total Electron Content (TEC) nighttime observations of OI 135.6 emission. takes into...
Transcriptome analysis is important for interpreting the functional elements of genome and revealing molecular constituents cells tissues. Herein, differentially transcribed genes were identified by deep sequencing after zebrafish (Danio rerio) exposed to β-diketone antibiotics (DKAs); 23,129 23,550 mapped detected in control treatment groups, a total 3238 expressed between groups. Of these genes, 328 (213 up- 115 down-regulation) had significant differential expression (p < 0.05) an ratio...
Activation of protein C is greatly enhanced by the presence thrombomodulin (TM) and endothelial receptor (EPCR) on surface. Impairment anticoagulant system occurs during endotoxemia contributes to sepsis-associated hypercoagulability. Previous studies have demonstrated that unfractionated heparin (UFH) can attenuate coagulation in endotoxemic mice. However, whether UFH has an effect remains be elucidated. The current study evaluated therapeutic a mouse model lipopolysaccharide (LPS)-induced...
A multi-generational approach was used to investigate the persistent effects of a sub-lethal dose spinosad in Plutella xylostella.The susceptibility various sub-populations P. xylostella and insecticide on gene expression γ-aminobutyric acid receptor (GABAR) were determined.The results leaf dip bioassay showed that sensitivity decreased across generations.The sub-strains had been previously selected based determined LC 25 spinosad.Considering GABA-gated chloride channels are primary targets...