Gynostemma pentaphyllum (Thunb.) Makino (G. pentaphyllum) is a natural herbal drug that has been widely used to treat many diseases. The antitumor effects of G. were first described in the illustrated catalog plants. Gypenosides are major active components pentaphyllum, and they have reported possess prostate cancer, gastric hepatocellular carcinoma, colon lung breast cancer. However, research on use gypenoside treatment bladder cancer not conducted. In this study, we explored potential...

Abstract Bone metastasis is the most happened metastatic event in prostate cancer (PCa) and needs a large effort treatment. When PCa metastasizes to bone, new microenvironment can induce epigenome reprogramming stemness remodeling of cells, thereby increasing adaptability cells bone microenvironment, this even leads occurrence secondary tumor metastasis. Our group has previously found that RNA binding motif 3 (RBM3) affects stem cell-like properties by interfering with alternative splicing...

The active free radical species vary with supporting electrolyte during electrochemical advanced oxidation processes, thus, resulting into the significant difference in removal rate and degradation pathways of organic compounds. Herein, behavior tetracycline (TC) is studied based on boron‐doped diamond anode Na 2 SO 4 , NaCl, NaNO 3 systems. It revealed that ClO − initialize reaction TC followed by gradual through • OH. Notably, enhanced lifetime compared to ensures a more effective...

721 Background: High recurrence rates plague patients with nonmuscle invasive bladder cancer (NMIBC) following transurethral resection of tumors (TURBT). In response, we have developed a modified TURBT procedure that integrates en bloc resection, endoscopic submucosal dissection, and the injection chemotherapeutic drugs into submucosa (cESD-TURBT).This study aims to determine if cESD-TURBT yields better outcomes than conventional (cTURBT). Methods: This retrospective observational was...

Prostate cancer (PCa) is one of the most common cancers in male worldwide. Oxidative stress has been recognized as driving signals pathologically linked to PCa progression. Nevertheless, association oxidative with progression remains unclear. Western blot, q-RT-PCR and bioinformatics analyses were used examine PAGE4 expression. Comet assay Annexin V/ PI dual staining performed investigate DNA damage cell death under stress. Mouse xenograft model cells was established verify role vivo....

Renal cell carcinoma (RCC) is the most common type of kidney cancer. By analysing The Cancer Genome Atlas (TCGA) database, 16 genes were identified to be consistently highly expressed in RCC tissues compared with matched para‑tumour tissues. Using a high‑throughput viability screening method, it was found that downregulation only two significantly inhibited 786‑O cells. Among genes, pleckstrin homology domain containing O1 (PLEKHO1) has never been studied RCC, best our knowledge, and its...

It is now widely recognized that carcinoma-associated fibroblasts which are believed to be myofibroblasts, promote the transformation of prostate epithelial cells cancer cells, enhance their proliferation and invasiveness, induce acquisition resistance therapy immune evasiveness. Prostate-associated gene 4 (PAGE4) an intrinsically disordered protein remarkably prostate-specific. PAGE4 also a stress-response functions as transcriptional regulator upregulated in early-stage (PCa) its precursor...

Renal cell carcinoma (RCC) has the highest mortality rate of all urological malignancies. Clear renal (ccRCC) accounts for approximately 80% RCC cases and is often accompanied by accumulation lipid droplets. Growing evidence indicates that ccRCC a metabolism-related disease. Gypenosides are commonly used clinical treatment hyperlipidemia, their antitumor activity also been recognized. However, potential inhibitory effects mechanisms action gypenoside L (Gyp L) LI LI) in remain unclear. In...

Isobaric vapor–liquid equilibria (VLE) of binary systems formed by 1-chloro-2-ethylhexane + 2-ethyl-1-hexanol as well or p-xylene (PX), N-methylpyrrolidone (NMP) were determined at a pressure 40.0 kPa using recirculating still. The Wilson, nonrandom two-liquid (NRTL), and universal quasichemical (UNIQUAC) activity coefficient models used to describe the nonideality liquid phase. vapor phase was regarded ideal. experimental data checked with Herington consistency point test methods, which...

Objectives: To assess associations between short-time air pollution exposure and outpatient visits for pneumonia by the distributed lag nonlinear model (DLNM). Methods: Daily pollutant data were collected from Wuhan Basic Medical Insurance Database in China 10 national quality monitoring stations 2014 to 2017, respectively. Taking first percentile of concentration as reference, DLNM was used estimate impact moderate (50th) high levels (99th) pollutants on pneumonia. Results: A total 133,882...

596 Background: Althoughradical cystectomy (RC) in combination with cisplatin-based neoadjuvant chemotherapy is the gold-standard for muscle-invasive bladder carcinoma (MIBC), bladder-sparing treatment have emerged to be an alternative choice patients who are concerning about life quality after surgery. The optimal strategy such as trimodal therapy (TMT) showed similar effect RC. Since TRUCE-01 has illuminated considerable response of immunotherapy MIBC, we aim study whether plus can improve...

Potatoes are widely planted worldwide and the third most important food crop. Mutation breeding involves artificial use of various physical chemical factors to induce plants produce new genotypes. In this study, we established a potato radiation mutation system analysed features mutant. The LD50 callus was 24.8 Gy after linear regression analysis. mutant 1 (RM1) showed significant dwarfism strong growth; RM1 decreased in height by 31%. root leaf fresh weights increased 1.8-fold compared...

In this article we introduced a raspberry-like particle-assisted breath figures method to simultaneously fabricate superhydrophobic surfaces with different adhesions. Firstly, SiO2 particles were in situ generated on the surface of styrene copolymer microspheres form composite particles, and then simply separated products according distribution differences structures reactor. Finally, was prepared by (BF) method. The hydrophobic wall bottom reactor showed distinct adhesion, former...

While the COVID-19 epidemic has had an unprecedented impact and on traditional economic model, it played a huge role in promoting new retail industry.Under epidemic, one hand, industry chain successfully penetrated into fresh food field, which raised awareness of management formed format.On other as consumers develop consumption habits, will be highly integrated with online offline businesses, continue to broaden customer base through social marketing digital technology, accelerate...

Abstract In this article, the titanium‐oxo cluster containing bromine had been prepared by solvothermal synthesis, which was used to initiate atom transfer radical polymerization of butyl methacrylate in order obtain organic–inorganic hybrid materials. The structures and compositions its materials were characterized X‐ray photoelectron spectroscopy (XPS), 1 H nuclear magnetic infrared spectra tests. with different molecular weights dissolved tetrahydrofuran coated on surface polyethylene...

In this study, the grain boundary character distribution (GBCD) of γ-TiAl-based alloy was modified through thermomechanical processing route. A compression test conducted to identify mechanical property improvements based on engineering (GBE) treatment. After multidirectional isothermal forging (MDIF) and annealing, average size refined 20 µm. The length ratio low Σ (1 ≤ 29) coincidence site lattice (CSL) boundaries increased 64.01%, with exhibiting a higher compressive strength (2913 MPa)...