A5101863119- Advanced biosensing and bioanalysis techniques
- Ginseng Biological Effects and Applications
- RNA Interference and Gene Delivery
- Natural product bioactivities and synthesis
- Biosensors and Analytical Detection
- Marine Toxins and Detection Methods
- Traditional Chinese Medicine Analysis
- Pharmacological Effects of Natural Compounds
- Advanced Nanomaterials in Catalysis
- Marine and coastal ecosystems
- Molecular Sensors and Ion Detection
- Medicinal Plant Pharmacodynamics Research
- Molecular Junctions and Nanostructures
- Toxin Mechanisms and Immunotoxins
- Chromatography in Natural Products
- Carbon and Quantum Dots Applications
- Nanocluster Synthesis and Applications
- Cancer-related molecular mechanisms research
- Advanced Chemical Sensor Technologies
- Hedgehog Signaling Pathway Studies
- Microbial Metabolism and Applications
- Liver physiology and pathology
- Retinoids in leukemia and cellular processes
- Hippo pathway signaling and YAP/TAZ
- Biological Activity of Diterpenoids and Biflavonoids
Harbin Institute of Technology
2022-2025
Nanjing University of Chinese Medicine
2015-2024
Minzu University of China
2020-2022
First Affiliated Hospital of Zhengzhou University
2017-2022
Weihai Science and Technology Bureau
2022
Chongqing Medical University
2018-2021
Chongqing Medical and Pharmaceutical College
2021
Zero to Three
2018
Ningxia Medical University
2011
Background/Aims: The Hippo-Yap pathway is associated with tumor development and progression. However, little evidence available concerning its role in cancer cell apoptosis migration via mitochondrial homeostasis. Here, we identify fission as a regulator of the Hippo–Yap human rectal tumorigenesis metastasis. Methods: In this study, performed loss-of function assays Yap RCC shRNA. Cellular viability were measured MTT, TUNEL assay trypan blue staining. Mitochondrial was assessed JC1 staining,...
Abstract Here, we have presented a green and facile strategy to fabricate nitrogen‐doped carbon dots (N‐CDs) their applications for determination of chlortetracycline (CTC) sulfasalazine (SSZ). The fluorescent N‐CDs, prepared by one‐step hydrothermal reaction citric acid l ‐arginine, manifested numerous excellent features containing strong blue fluorescence, good water‐solubility, narrow size distribution, high fluorescence quantum yield (QY) 38.8%. Based on the quenching effects,...
Sinisan has been widely used to treat depression. However, its pharmacologically-effective constituents are largely unknown, and the pharmacological effects clinical efficacies of Sinisan-containing processed medicinal herbs may change. To address these important issues, we developed an ultra-high performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) method multiple statistical strategies analyze compound...
Gynostemma pentaphyllum has been used as a medicine-food homologious health product in China for long time. This research aimed to isolate and identify its active compounds with protective effects against hydrogen peroxide induced SH-SY5Y cell death. Four new dammarane-type saponins were isolated from G. using various chromatographic methods. They identified gypenoside S1 (1), S3 (2), S2 (3) S4 (4), respectively by HRESIMS NMR spectra. Their cytotoxic activity was evaluated three human...
This study was designed to evaluate the toxic effects of total diterpenoids extracted from roots Euphorbia pekinensis (TDEP) on mouse colon and clarify mechanism. Dried powdered E. were with chloroform, then extract (6.7 g) subjected column chromatography preparative TLC, giving TDEP. Using HPLC-DAD method, purity TDEP determined as 85.26%. Mice orally administered (3.942, 19.71 39.42 mg/kg), after which fecal water content examined. Both them increased over time administration, accompanied...
Renal cell carcinoma (RCC) has the highest mortality rate of all urological malignancies. Clear renal (ccRCC) accounts for approximately 80% RCC cases and is often accompanied by accumulation lipid droplets. Growing evidence indicates that ccRCC a metabolism-related disease. Gypenosides are commonly used clinical treatment hyperlipidemia, their antitumor activity also been recognized. However, potential inhibitory effects mechanisms action gypenoside L (Gyp L) LI LI) in remain unclear. In...
Abstract A novel and simple electrochemical strategy has been developed for ultrasensitive specific detection of BCR/ABL fusion gene based on multi component nucleic acid enzyme (MNAzyme) ssDNA‐assisted cascade hybridization reaction. In the presence Mg 2+ , a stable active MNAzyme was formed by homogeneous recognition binding with target, initiating shear reaction hairpin probe (HP) to produce numerous triggers. These triggers could hybridize immobilized capture probes biotinylated P1 P2,...
The effect of biomechanical force on growth skeletal tissue was studied in monolayer cultures mouse osteoblastic MC3T3-E1 cells which were centrifuged at 320 g for 15 min to 72 h a CO 2 incubator. Centrifugation the 30 low concentrations (0.3 or 1%) fetal bovine serum (FBS) caused two-fold increase [ 3 H]thymidine incorporation 20 from start centrifugation. However, centrifugation under 10% FBS no [3H]thymidine into DNA. Under 0.3% FBS, increased manner dependent period and reached maximum...