A5060223039- Biofuel production and bioconversion
- Enzyme Production and Characterization
- Microbial Metabolic Engineering and Bioproduction
- Thyroid Cancer Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Thyroid and Parathyroid Surgery
- Enzyme Catalysis and Immobilization
- Osteoarthritis Treatment and Mechanisms
- Amino Acid Enzymes and Metabolism
- Fungal and yeast genetics research
- Landslides and related hazards
- Parathyroid Disorders and Treatments
- Catalysis for Biomass Conversion
- Proteoglycans and glycosaminoglycans research
- Cardiac electrophysiology and arrhythmias
- Enzyme Structure and Function
- Seismology and Earthquake Studies
- Total Knee Arthroplasty Outcomes
- Electrodeposition and Electroless Coatings
- Orthopaedic implants and arthroplasty
- Head and Neck Anomalies
- Marine Biology and Environmental Chemistry
- Neuroendocrine Tumor Research Advances
- Environmental Toxicology and Ecotoxicology
Palo Alto University
2024
Stanford University
2024
International University of Health and Welfare
2023-2024
National Institute of Advanced Industrial Science and Technology
2013-2023
Osaka University
1997-2023
Hiroshima Prefectural Hospital
2011-2022
Sakurabashi Watanabe Hospital
2017-2021
Canon (Japan)
2018
Hiroshima Institute of Technology
2017
Kobe University
2002-2016
The effectiveness of ball milling (BM) and wet disk (WDM) on treating sugarcane bagasse straw were compared. Pretreated materials characterized by wide angle X-ray diffraction analysis, particle-size distribution scanning electron microscopy the pretreatments was evaluated enzymatic hydrolysis fermentation. Glucose xylose yields at optimum conditions for BM-treated 78.7% 72.1% 77.6% 56.8%, respectively. Maximum glucose using WDM 49.3% 36.7% 68.0% 44.9%, BM improved decreasing crystallinity,...
Background: Detectable serum thyroglobulin (Tg) in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy implies unsuccessful surgery, indicating a high risk of recurrence. Serum Tg kinetics such have not been extensively studied. We studied suppressed thyrotropin levels and undetectable anti-Tg antibody to minimize the effects these factors on values, evaluated relationship prognosis doubling-time. Methods: Between January 1998 December 2004, 1515 PTC underwent Kuma...
The DNA polymerase gene from the archaeon Pyrococcus sp. strain KOD1 (KOD polymerase) contains a long open reading frame of 5,013 bases that encodes 1,671 amino acid residues (GenBank accession no. D29671). Similarity analysis revealed contained putative 3'-5' exonuclease activity and two in-frame intervening sequences 1,080 bp (360 acids; KOD pol intein-1) 1,611 (537 intein-2), which are located in middle regions conserved among eukaryotic archaeal alpha-like polymerases. mature form was...
Recent studies have demonstrated that BRAFV600E mutation is a common event in papillary thyroid carcinoma and majority of these lesions shown direct relationship between aggressive characteristics, including worse patient prognosis. However, there are no from Japan regarding this issue large series with adequate postoperative follow-up periods. We investigated 631 patients having median periods 83 months. The prevalence was 38.4%, the rate higher larger than 1.0 cm but did not successively...
Lignocellulosic biomass such as wood is an attractive material for fuel ethanol production. Pretreatment technologies that increase the digestibility of cellulose and hemicellulose in lignocellulosic have a major influence on cost subsequent enzymatic hydrolysis fermentation processes. Pretreatments without chemicals acids, bases or organic solvents are less effective process than those with chemicals, but they negative effect environment. The eucalyptus was examined following combined...
Lymph node metastasis is an important clinicopathological feature of papillary thyroid carcinoma (PTC). PTC having clinically apparent lateral detectable on preoperative imaging studies (N1b) known to show a dire prognosis. However, N1b cases include various levels biological aggressiveness, depending the size, number, laterality and invasiveness metastatic nodes. We investigated differences in prognoses 621 patients based these features compared their with those 4297 without (N0) 125...
Cartilage is unique among tissues of mesenchymal origin in that it resistant to vascular invasion due an intrinsic angiogenic inhibitor. During endochondral bone formation, however, calcified cartilage formed the center cartilaginous rudiment allows invasion, which initiates replacement by bone. The transition from angioresistant status thus plays a key role formation. However, molecular basis this phenotypic has been obscure. We report here purification endothelial cell growth inhibitor...
We studied the effects of highly purified bone morphogenetic protein 2 and 3 (BMP-2 -3) on growth plate chondrocytes osteoblastic cells in vitro compared to TGF-beta. A mixture BMP-2 (BMPs) strongly stimulated DNA synthesis presence fibroblast factor (FGF). BMPs induced rapid maturation at a growing stage: transformed into rounded marked accumulation cartilage matrix; TGF-beta slightly reduced matrix changed cell morphology spindle-like FGF. Moreover, exposure resulted dramatic increase...
Bioethanol isolated from lignocellulosic biomass represents one of the most promising renewable and carbon neutral alternative liquid fuel sources. Enzymatic saccharification using cellulase has proven to be a useful method in production bioethanol. The filamentous fungi Acremonium cellulolyticus Trichoderma reesei are known potential producers. In this study, we aimed reveal advantages disadvantages enzymes derived these fungi.We compared A. T. activity against three materials: eucalyptus,...
Enzymatic hydrolysis of pretreated lignocellulosic biomass is an essential process for the production fermentable sugars industrial use. A better understanding fungal cellulase systems will provide clues maximizing target biomass. Talaromyces cellulolyticus a promising fungus and efficient hydrolysis. Several cellulolytic enzymes purified from T. were characterized in earlier studies, but core critical remain unknown. Six crystalline cellulose culture supernatant using enzyme assay based on...
Abstract The effects of transforming growth factor‐beta (TGF‐beta) on the synthesis cartilage‐matrix proteoglycan by cultured rabbit chondrocytes were examined. Rabbit seeded at low density and exposed to a 1:1 mixture Dulbecco's modified Eagle's medium Ham's F‐12 supplemented with 0.5% fetal bovine serum, 1% serum albumin, 50μg/ml ascorbic acid, 2 × 10 −7 M hydrocortisone (Medium A). Various combinations TGF‐beta, insulin‐like factor–l (IGF–I), fibroblast factor (FGF) also added Medium A,...
Epidermal growth factor (EGF) stimulated DNA synthesis, RNA synthesis and cell division of rabbit costal chondrocytes in culture, but did not stimulate nor inhibit proteoglycan synthesis. Multiplication‐stimulating activity (MSA) cartilage‐derived (CDF) with somatomedin‐like had relatively small effects on chondrocytes, markedly enhanced the sulfated proteoglycans. MSA EGF additive or synergistic chondrocytes. fibroblast (FGF) also CDF mimicked these MSA; similar stimulatory even presence...