A5026084717- Thyroid Cancer Diagnosis and Treatment
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Voice and Speech Disorders
- Radiomics and Machine Learning in Medical Imaging
- Ovarian cancer diagnosis and treatment
- Tracheal and airway disorders
- Neuroendocrine Tumor Research Advances
- Pituitary Gland Disorders and Treatments
- Organ Transplantation Techniques and Outcomes
- Cancer Treatment and Pharmacology
- Radiation Dose and Imaging
- Thyroid Disorders and Treatments
- Advanced Breast Cancer Therapies
- Transplantation: Methods and Outcomes
- Breast Cancer Treatment Studies
- Parathyroid Disorders and Treatments
- Airway Management and Intubation Techniques
- BRCA gene mutations in cancer
- Liver Disease and Transplantation
- Dysphagia Assessment and Management
- Renal Transplantation Outcomes and Treatments
- Renal cell carcinoma treatment
- Otolaryngology and Infectious Diseases
- Cancer and Skin Lesions
Kuma Hospital
2016-2025
Red Cross Hospital
2009
Tohoku University
2003-2006
University of Tsukuba
2004
The incidence of papillary microcarcinoma (PMC) the thyroid is rapidly increasing globally, making management PMC an important clinical issue. Excellent oncological outcomes active surveillance for low-risk have been reported previously. Here, unfavorable events following and surgical treatment were studied.From February 2005 to August 2013, 2153 patients diagnosed with PMC. Of these, 1179 chose 974 immediate surgery. incidences these groups analyzed.In group, 94 underwent surgery various...
Background: Detectable serum thyroglobulin (Tg) in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy implies unsuccessful surgery, indicating a high risk of recurrence. Serum Tg kinetics such have not been extensively studied. We studied suppressed thyrotropin levels and undetectable anti-Tg antibody to minimize the effects these factors on values, evaluated relationship prognosis doubling-time. Methods: Between January 1998 December 2004, 1515 PTC underwent Kuma...
Background: It has been 30 years since the initiation of active surveillance (AS) for adult patients with low-risk papillary thyroid microcarcinoma (PTMC). This study compared long-term oncological outcomes who underwent AS or immediate surgery (IS). Methods: is a retrospective review extended follow-up data from enrolled in single-center, prospective observational Japan. In total, 5646 diagnosed PTMC at Kuma Hospital between 1993 and 2019 were this study. Of these, 3222 (AS group), whereas...
We reported that a minority of patients with low-risk papillary microcarcinoma the thyroid showed disease progression during active surveillance and older had significantly lower rates than younger patients. Here, we estimated lifetime (≤85 years old) probabilities according to age at presentation based on decade-specific rates.From 1993-2013, 1,211 aged 20-79 underwent Kuma Hospital. calculated rate 10-year point for each age-decade group (20s 70s) Kaplan-Meier method. The probability was...
The incidence of thyroid cancer is increasing rapidly in many countries, resulting rising societal costs the care cancer. We reported that active surveillance low-risk papillary microcarcinoma had less unfavorable events than immediate surgery, while oncological outcomes these managements were similarly excellent. Here we calculated medical two managements. created a model flow managements, based on our previous study. and include step diagnosis, prescription medicine, recurrence, salvage...
BackgroundWe report on the growth of papillary microcarcinoma during active surveillance and before clinical presentation.MethodsWe conducted a retrospective study 169 patients with who were enrolled in at our hospital between 2000 2004. Patients followed for median 10.1 years using serial ultrasonography (median, 12 examinations), used to calculate tumor doubling time. To contextualize rates surveillance, we calculated hypothetical time presentation. resolve limitations time, inversely...
Background: Active surveillance (AS) of low-risk papillary thyroid microcarcinoma (PMC) was adopted as a management modality in both the Japanese guidelines 2011 and American Thyroid Association 2015. AS initiated at Kuma Hospital 1993 but not immediately accepted by all physicians. This study investigated history acceptance over time. The results should assist implementation other hospitals Japan countries. Methods: included 4023 patients who were cytologically diagnosed with PMC during...
Abstract Fine needle aspiration (FNA) is the procedure of choice for evaluating thyroid nodules. It indicated nodules >2 cm, even in cases very low suspicion malignancy. FNA has associated risks and expenses. In this study, we developed an image analysis model using a deep learning algorithm evaluated if could predict with benign results. Ultrasonographic images cytologic or histologic results were retrospectively collected. For training, 1358 (670 benign, 688 malignant) nodule input into...
Follicular thyroid carcinoma (FTC) is divided into two categories: minimally and widely invasive FTC. Generally, the prognosis of FTC excellent, but patients showing certain characteristics have a dire prognosis. In this study, we investigated prognostic factors using series 292 patients. On multivariate analysis, extensive (4 or more) vascular invasion, age ≥ 45 years, tumor size > 4 cm were independent patient disease-free survival (DFS). Distant metastasis at diagnosis (M1) was strongest...
An active-surveillance clinical trial of low-risk papillary microcarcinoma (PMC) patients has been performed at the authors' institution, Kuma Hospital, since 1993. Favorable oncological results have reported. During trial, a few were encountered with PMC that showed enlargement during pregnancy, and these cases large amount human chorionic gonadotropin (hCG) having weak thyrotropin (TSH) activity is produced, possibly affecting progression PMC. This study investigated how pregnancy delivery...
Background Federated learning is a decentralized approach to machine learning; it training strategy that overcomes medical data privacy regulations and generalizes deep algorithms. mitigates many systemic risks by sharing only the model parameters for training, without need export existing sets. In this study, we performed ultrasound image analysis using federated predict whether thyroid nodules were benign or malignant. Objective The goal of study was evaluate performance comparable with...
Pyriform sinus fistulae are the major routes of infection in acute suppurative thyroiditis (AST). There have been only a few reports describing imaging studies AST. We reviewed our patients with AST to elucidate its features so as facilitate diagnosis and treatment.We ultrasonography (US) examinations, computed tomography (CT) scans, barium swallow performed on 60 who were seen for medical care between 1998 2008 retrospectively reviewed. All these had pyriform fistulae.In inflammatory stage,...
Although postoperative serum thyroglobulin (Tg) is a prognostic indicator for papillary thyroid carcinoma (PTC), it unreliable when Tg antibody (TgAb) positive. We evaluated the significance of changes in TgAb levels pre- and post-total thyroidectomy TgAb-positive PTC patients. reviewed our medical charts 225 patients whom were measured before 1-2 years after total thyroidectomy, performed between April 2002 March 2007. divided them into 3 groups based on levels. Postoperative decreased by ≥...
The purpose of this study was to evaluate electromyography (EMG) amplitude and latency changes during tube dislocation in monitored thyroid surgery, which may be observed without recurrent laryngeal nerve injury.Duroc-Landrace piglets were intubated with the TriVantage EMG tube. We measured both upward downward (10-20 mm) rotation (45-90°) continuous neuromonitoring.The varied significantly induced endotracheal depth changes. However, relatively unaffected by such dislocation, just a...
Background: Although papillary thyroid microcarcinoma (PMC) is generally stable on active surveillance, conversion surgery recommended for enlarging tumors. However, it remains unclear which enlargement threshold should be considered sufficient to trigger surgery. This study analyzed changes in the growth activity of PMC, before and after enlargement. Methods: We enrolled 824 patients with whom surveillance was initiated between 2005 2011 (median duration follow-up: 6.04 years). Changes...
Background: We previously reported that the Ki-67 labeling index (LI) in primary tumors and thyroglobulin (Tg)-doubling time (DT) were potent prognostic indicators patients with papillary thyroid carcinoma (PTC). Objectives: To elucidate relationship between these two factors. Methods: A total of 390 PTC who underwent thyroidectomy 1998 2004 whom Tg-DT was calculated enrolled. determined LI compared values patients' clinicopathological factors, postoperative Tg status, Tg-DT, prognosis....
Distant metastasis (DM) at surgery is a prominent prognostic factor in patients with papillary carcinoma of the thyroid. However, clinical outcomes these (M1 patients) remain unclear. In this study, we investigated prognosis and factors M1 patients. Seventy-one 5969 who underwent initial Kuma Hospital between 1987 2004 were classified as enrolled study. Five-year 10-year cause specific survival (CSS) rates 78.8 +/- 5.2% 76.3 5.7%, respectively. Patients aged 55 years or older, having tumor...
Preoperative localization study is difficult in patients with primary hyperparathyroidism (PHPT) caused by intrathyroidal parathyroid adenoma. The objective of this was to evaluate the usefulness ultrasonography (US) diagnosis Between January 2004 and December 2009, seven 373 who underwent parathyroidectomy because PHPT our hospital were found have ultrasonographic features adenoma examined retrospectively. most characteristic feature a hyperechoic line on ventral surface gland. A clearly...
The external branch of the superior laryngeal nerve (SLN) is susceptible to injuries during thyroidectomy, causing voice impairment. Intraoperative monitoring may facilitate identification nerve, reducing impairment.A total 252 patients undergoing thyroidectomy were randomly assigned group N (the NIM-Response 3.0 system was used) or C conventional technique using Vari-Stim 3 identify SLNs. primary endpoint rate SLN. secondary incidence postoperative impairment.The visual and...
In contrast to minimally invasive follicular thyroid carcinoma (FTC), widely FTC is aggressive and associated with a dire prognosis. However, prognostic factors of have not been intensively investigated. this study, we investigated issue in series 79 patients. the subset 70 patients who did show distant metastasis at diagnosis (M0), only tumor size larger than 4 cm had impact on disease-free survival (DFS) both uni- multivariate analyses. Regarding cause-specific (CSS) patients, (M1)...
Differentiated thyroid carcinomas (DTCs) are generally indolent, but few therapeutic strategies available after a metastatic recurrence that is refractory to radioactive iodine (RAI) therapy. Molecular-target therapy has shown promising results for DTCs with RAI-refractory recurrence. However, not all recurrences progressive, and even those progressive may be immediately life-threatening. Here we investigated the prognosis prognostic factors of 74 DTC patients (52 females, 22 males) in whom...
The World Health Organization (WHO) classifies follicular thyroid carcinoma (FTC) into three categories: minimally invasive (mFTC), encapsulated angioinvasive (eaFTC), and widely (wFTC). This study investigated whether this classification is appropriate. We enrolled 523 patients who underwent initial surgery at Kuma Hospital between 1998 2015 were diagnosed with FTC. Capsular invasion (CI) was classified as none, minimal (microscopic), or wide (macroscopic) invasion. Vascular (VI) divided...