A5072235552- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Thyroid and Parathyroid Surgery
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Lymphoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Urinary and Genital Oncology Studies
- Tumors and Oncological Cases
- Sarcoma Diagnosis and Treatment
- Soft tissue tumor case studies
- Parathyroid Disorders and Treatments
- Cancer and Skin Lesions
- Renal and related cancers
- Cervical Cancer and HPV Research
- Urologic and reproductive health conditions
- Ovarian cancer diagnosis and treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Ocular Oncology and Treatments
- Genetic Syndromes and Imprinting
Kuma Hospital
2017-2023
Nagasaki University
2023
Kyorin University
2023
Takamatsu Red Cross Hospital
2016-2017
Kagawa University
2009-2015
In-Q-Tel
2015
University Health Network
2014
Clinical Emergency Hospital Bucharest
2012
Kagawa University Hospital
2009-2010
Background: It has been 30 years since the initiation of active surveillance (AS) for adult patients with low-risk papillary thyroid microcarcinoma (PTMC). This study compared long-term oncological outcomes who underwent AS or immediate surgery (IS). Methods: is a retrospective review extended follow-up data from enrolled in single-center, prospective observational Japan. In total, 5646 diagnosed PTMC at Kuma Hospital between 1993 and 2019 were this study. Of these, 3222 (AS group), whereas...
Noninvasive encapsulated follicular variant of papillary thyroid carcinoma (PTC) was reclassified as noninvasive neoplasm with papillary-like nuclear features (NIFTP). To date, no studies on NIFTP have been reported in Japan. This study aimed to evaluate the clinical, cytological, and pathological findings 54 cases from a single center Japan, compare them those western countries. There were significant differences age, sex, or tumor size between patients invasive -PTC. Ultrasound...
The molecular pathogenesis of gastroenteropancreatic (GEP) neuroendocrine tumours (NETs) remains to be elucidated. High-mobility group A (HMGA) proteins play important roles in the regulation transcription, differentiation, and neoplastic transformation. In this study, expression HMGA1 HMGA2 was studied 55 GEP NETs. Overexpression 2 frequently detected NETs compared with normal tissues. Nuclear immunostaining observed (38 55, 69%; 40 73%, respectively). A2 increased from well-differentiated...
Many cytological studies on medullary thyroid carcinoma (MTC) have been reported; however, such in large series of patients with MTC not performed. We investigated at a single institution Japan using fine-needle aspiration cytology (FNAC), and aimed to establish preoperative diagnostic algorithm for MTC. FNAC was performed 119 149 (79.9%) who ultimately underwent surgical resection. Moreover, 22 56 hereditary (39.3%) were diagnosed preoperatively without by their high serum calcitonin levels...
Abstract Background We aimed to determine the indication of fine‐needle aspiration (FNA) for parathyroid adenoma (PA)‐suspected nodules and cytological features PA, discuss ancillary techniques diagnostic confirmation. Method Clinical, cytological, histological examinations 15 PA patients (4.0% all resected patients) were conducted through FNA on 16 nodules. also examined preparations 10 follicular neoplasms (FNs) poorly differentiated thyroid carcinomas (PDTCs). Results was performed detect...
Thyroid tumors arising from follicular cells can generally be divided into malignant and benign tumors. However, some cases are difficult to clearly diagnose whether they or malignant. Therefore, in the most recent version of World Health Organization (WHO) classification, borderline lesions such as tumor uncertain potential (FT-UMP), well-differentiated (WDT-UMP), noninvasive thyroid neoplasm with papillary-like nuclear features (NIFTP) were proposed. In this study, we investigated clinical...
Abstract Primary lymphoepithelioma‐like carcinoma (LELC) of the lung is an extremely rare disease that occurs more commonly in Asians, and composed undifferentiated with prominent lymphoid stroma. LELC reported to be closely associated Epstein‐Barr virus (EBV) infection. A case presented here which bronchial brushing smears a 70‐year‐old man, revealed large clusters neoplastic cells scant cytoplasm. The nuclei were large, hyperchromatic, irregular contour nucleoli. Also identified...
Concerning the needle size for thyroid fine aspiration cytology (FNAC), 25-27-gauge needles are generally used in Western countries. However, Japan, use of larger (21-22-gauge needles) is common. The aim our study was to determine optimal FNAC. We performed ultrasound-guided FNAC 200 nodules patients using two different-sized (22 and 25 gauge). For each nodule, passes with were performed. order sizes reversed second group 100 nodules. more painful than first, regardless size. An association...
Follicular cell-derived thyroid carcinomas, including squamous cell carcinomas (SCCs) and anaplastic are immunoreactive for paired-box gene 8 (PAX8), while non-follicular stain negative the PAX8 antibody. Intrathyroid thymic carcinoma (ITTC) arising from intrathyroidal ectopic thymus exhibits moderate-to-strong nuclear reactivity polyclonal PAX8. This is difficult to understand given that not associated with embryonic development. We aimed determine diagnostic significance of monoclonal...
Abstract Background Needle tract implantation (NTI) can occur after thyroid fine‐needle aspiration cytology (FNAC). To date, no studies enrolling a large number of patients and studying the cumulative incidence (CI) NTI have been published. This study analyzed clinicopathological features calculated CI. Methods A total 11,745 who underwent first FNAC, resection for carcinomas related lymph node metastases, postoperative ultrasonography in Kuma Hospital between 2006 2017 were evaluated. was...
PAPILLARY THYROID CARCINOMA (PTC) has many morphologic variants.PTC can present with extensive proliferation of fibroblasts and myofibroblasts in the stroma.This variant is extremely rare been described terms "PTC exuberant nodular fasciitis-like stroma" [1], [2], fibromatosis-like [3], forming a myofibroblastic tumor" [4].Recently, Rebecchini et al. proposed that should be renamed PTC desmoid-type fibromatosis (DTF) because mesenchymal component showed aberrant nuclear cytoplasmic immu-
For the differential diagnosis of medullary thyroid carcinoma (MTC) on nodules, ultrasound-guided fine-needle aspiration cytology is a useful and safe procedure, but its diagnostic accuracy not high enough. As an ancillary method to accurately diagnose MTC, calcitonin in aspirate washout fluid (FNA-Ct) used. However, no data are available about cut-off values FNA-Ct using currently electrochemiluminescence immunoassay (ECLIA).We investigated 180 nodules 141 patients. After smearing, syringe...
The incidence of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) in papillary carcinoma (PTC) is significantly lower Asian countries than Western countries; however, the difference remains unexplained. This study aimed to evaluate NIFTP tumors diagnosed as adenoma (FA) a Japanese institution and discuss significance NIFTP. In this study, 44 were investigated, which histologically FA at Kuma Hospital 2008. Of tumors, 13 (29.5%) revised remaining 31...
Background: A significant increase in the incidence of papillary thyroid carcinoma (PTC) subjects exposed to radiation at a young age is well-documented health consequence Chernobyl accident. The ongoing Thyroid Ultrasound Examination (TUE) program children and adolescents Fukushima Prefecture Japan also indicated high prevalence PTC although its attribution exposure subject debate. objective this study was perform histopathological analysis tumor architecture invasive properties (i)...
Pulmonary mixed squamous cell and glandular papilloma is an extremely rare neoplasm. This the first cytological report of such a A 59-year-old Japanese man was admitted to hospital complaining persistent cough bloody sputum. bronchial endoscopic examination revealed endobronchial polypoid tumor. Upon brush cytology by Papanicolaou stain, dysplasia showing mild atypia suspected. The smears showed moderate cellularity with singly scattered cells or loose clusters cells, consisting few columnar...
The Bethesda System for Reporting Thyroid Cytopathology has recently been revised in 2017 (TBSRTC 2017). This study aimed to evaluate the impact of modifying diagnostic criteria TBSRTC at a single institute. We retrospectively reviewed cytological specimens 10,399 thyroid nodules submitted fine-needle aspiration cytology. Among them, 56 atypia undetermined significance or follicular lesion (AUS/FLUS) nodules, 16 suspicious malignancy (SFM) and 8 malignant were re-categorized into neoplasm...
Abstract Background The number of extensive studies focusing on cyst fluid only (CFO) thyroid nodules is limited, and the risk malignancy (ROM) in CFO has not been well‐established. Thus, purpose this study was to investigate using cytology ultrasound. In addition, we sought define ROM determine recommended clinical management nodules. Methods We retrospectively reviewed cytological preparations 678 that were originally identified as nodules, including conventional specimens 209 liquid based...
The definition of tall cell variant papillary thyroid carcinoma (TCV-PTC) depends on the articles, and defined cytological findings characteristic TCV-PTC have not yet been fully analyzed. This study aimed to establish characteristics TCV-PTC.We retrospectively analyzed smears 19 50 conventional PTC (C-PTC) cases.Palisaded pattern with nuclei locating at base columnar cells was seen in 94.7% TCV-PTCs, incidence significantly higher than that C-PTCs (P < .0001). palisaded tended appear...