A5100368657- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- Retinal Diseases and Treatments
- Caveolin-1 and cellular processes
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Heme Oxygenase-1 and Carbon Monoxide
- COVID-19 Impact on Reproduction
- Biotin and Related Studies
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- MicroRNA in disease regulation
- ATP Synthase and ATPases Research
- Endoplasmic Reticulum Stress and Disease
- Redox biology and oxidative stress
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
- Cellular transport and secretion
- Cardiac Arrest and Resuscitation
- Genomics, phytochemicals, and oxidative stress
- Sirtuins and Resveratrol in Medicine
- TGF-β signaling in diseases
- Connective Tissue Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Cell death mechanisms and regulation
University of Iowa
2014-2024
UCLA Health
2024
University of California, Los Angeles
2024
Renmin Hospital of Wuhan University
2009-2024
Wuhan University
2009-2024
Southeast University
2024
Fraternal Order of Eagles
2015-2024
Cleveland Clinic Lerner College of Medicine
2022-2023
Wenzhou Medical University
2023
Gansu Agricultural University
2023
To assess the management and safety of epidural or general anesthesia for Cesarean delivery in parturients with coronavirus disease (COVID-19) their newborns, to evaluate standardized procedures protecting medical staff.We retrospectively reviewed cases diagnosed severe acute respiratory syndrome (SARS-CoV-2) infection (COVID-19). Their epidemiologic history, chest computed tomography scans, laboratory measurements, SARS-CoV-2 nucleic acid positivity were evaluated. We also recorded...
Mechanical strain plays a critical role in the proliferation, differentiation and maturation of bone cells. As mechanical receptor cells, osteoblasts perceive respond to stress force, such as those associated with compression, shear stress. However, underlying molecular mechanisms this process remain unclear. Using four-point bending device, mouse MC3T3-E1 cells was exposed tensile strain. Cell proliferation determined be most efficient when stimulated once day by at frequency 0.5 Hz...
Inhibiting the actions of VEGF is a new therapeutic paradigm in cancer management with antiangiogenic therapy also under intensive investigation range nonmalignant diseases characterized by pathological angiogenesis. However, effects inhibition on organs that constitutively express it adulthood, such as kidney, are mostly unknown. Accordingly, we examined effect renal structure and function physiological conditions setting common stressors: hypertension activation renin-angiotensin system....
Hepatocellular carcinoma ( HCC ) is the sixth most prevalent cancer and third leading cause of cancer‐related deaths worldwide. The fate a cell determined by balance between processes fission fusion that constantly occur in mitochondria cells. We previously showed overexpression Mitofusin‐2 can induce apoptosis cells triggering an influx Ca 2+ into from ER . function has been studied extensively, but mechanism underlying post‐transcriptional regulation not elucidated. In present study, we...
Background/Aims: The Hippo-Yap pathway is associated with tumor development and progression. However, little evidence available concerning its role in cancer cell apoptosis migration via mitochondrial homeostasis. Here, we identify fission as a regulator of the Hippo–Yap human rectal tumorigenesis metastasis. Methods: In this study, performed loss-of function assays Yap RCC shRNA. Cellular viability were measured MTT, TUNEL assay trypan blue staining. Mitochondrial was assessed JC1 staining,...
Abstract Impaired autophagy is known to cause mitochondrial dysfunction and heart failure, in part due altered mitophagy protein quality control. However, whether additional mechanisms are involved the development of failure setting deficient autophagic flux remains poorly explored. Here, we show that impaired reduces nicotinamide adenine dinucleotide (NAD + ) availability cardiomyocytes. NAD deficiency upon impairment attributable induction N-methyltransferase (NNMT), which methylates...
Patients with diabetes are prone to develop cardiac hypertrophy and more susceptible myocardial ischemia–reperfusion (I/R) injury, which concomitant hyperglycemia-induced oxidative stress impaired endothelial nitric oxide (NO) synthase (eNOS)/NO signaling. Caveolae critical in the transduction of eNOS/NO signaling cardiovascular system. Caveolin (Cav)-3, cardiomyocytes-specific caveolae structural protein, is decreased diabetic heart production reactive oxygen species increased. We...
Epidemiological studies have shown that serum fibroblast growth factor 21 (FGF21) levels were elevated in obesity and its related metabolic disorders. This prospective study assessed whether there was an independent association of FGF21 with all-cause cardiovascular disease (CVD) mortality among patients coronary artery (CAD). A cohort 1668 CAD conducted. Their measured ELISA kits. Cox regression models used to estimate the risk mortality. During a median follow-up 4.9 years, 194 deaths...
α1-antitrypsin (AAT) is a serine protease inhibitor synthesized in hepatocytes and protects the lung from damage by neutrophil elastase. AAT gene mutations result deficiency (AATD), which leads to liver diseases. The Z variant forms polymer within endoplasmic reticulum (ER) of results reduction secretion severe disease. Previous studies demonstrated defect LMAN1 deficient cells, mild decreases levels male MCFD2 mice. transmembrane lectin that complex with small soluble protein MCFD2....
Dental pulp stem cells (DPSCs) had been widely used in nerve tissue engineering. However, the low cell survival and invalid differentiation were urgent problems to be solved for cell-based therapy. Platelet lysate (PL) attracted attentions its good biocompatibility, side effects abundant growth factors. In this study, we aimed evaluate effect mechanism of PL on proliferation angiogenesis DPSCs. our was prepared by repeated freeze-thaw methods. The viability DPSCs screened Cell Counting Kit-8...
Studies in rodent models have suggested that reduction renal transforming growth factor (TGF)-beta1 may underlie the renoprotective effects of renin-angiotensin system (RAS) blockade. However, role RAS blockade abrogating TGF-beta human disease is unknown. Accordingly, we sought to examine gene expression and biological activity biopsies, before after ACE inhibition.RNA was extracted from biopsies taken participants Diabiopsies study, a randomized controlled 2-year trial 4 mg/day perindopril...
Background— The objective of this study was to develop an acute experimental model showing both focal and macroreentrant sustained atrial fibrillation (AF). Methods Results— In 31 anesthetized dogs, bilateral thoracotomies allowed the attachment electrode catheters at right left superior pulmonary veins, free walls, appendages. Acetylcholine, 100 mmol/L, applied topically either appendage. Sequential radiofrequency ablation achieved for ganglionated plexi (GP), found adjacent 4 veins. 12...
Patients with diabetes are vulnerable to myocardial ischemia reperfusion (IR) injury, which may also induce acute lung injury (ALI) due overaccumulation of reactive oxygen species (ROS) and inflammation cytokine in circulation. Despite autophagy plays a significant role pulmonary IR the ALI secondary remains largely elusive. We aimed investigate status its roles oxidative stress reaction tissues from diabetic rats subjected IR. Control or were either treated without inducer rapamycin (Rap)...
Thioredoxin-interacting protein (TXNIP) is an endogenous inhibitor of the antioxidant thioredoxin, and a critical agent in vivo regulation glucose. The well-described induction TXNIP by high glucose may represent important pathogenic trigger complications arising diabetic environment, with sustained overexpression triggering increased production reactive oxygen species collagen, both major contributors to development nephropathy (DN). To examine possible therapeutic role for targeted...
Ruboxistaurin is an inhibitor of the β isoform protein kinase C (PKC-β) that reduces actions vascular endothelial growth factor (VEGF) and attenuates progression diabetic retinopathy. In glomerulus VEGF constitutively expressed where it likely has a role in maintaining cell integrity, particularly disease states. Given its potential use nephropathy, we sought to determine effects PKC-β inhibition on glomerular cells experimental nephropathy. Studies were conducted (mRen-2)27 rat, transgenic...
Mesenchymal stem cells (MSCs) are a population of pluripotent that have been tested for the treatment many inflammatory diseases. It remains unclear whether MSCs were effective in treating mice with alcoholic hepatitis (AH) and its underlying mechanism. In present study, isolated from bone marrow 4–6 week-old C57BL/6N male mice. AH was induced female by chronic-binge ethanol feeding 10 days. Intraperitoneal (i.p.) transplantation or saline performed on day 10. Blood samples hepatic tissues...
Background . Patients with diabetes are more vulnerable to myocardial ischemia reperfusion injury (IRI), which is involved in PKC β 2 activation and mitochondrial dysfunction. Glycine has been documented as a cytoprotective agent attenuate diabetes-related abnormalities reduce IRI, but the underlying mechanisms still unclear. We determined whether glycine could high glucose- (HG-) hypoxia/reoxygenation- (H/R-) induced by inhibiting improving quality cultured H9C2 cells. Methods cells were...