A5019035094- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Blood Coagulation and Thrombosis Mechanisms
- HER2/EGFR in Cancer Research
- COVID-19 Clinical Research Studies
- Peptidase Inhibition and Analysis
- Biomedical Text Mining and Ontologies
- Cancer Mechanisms and Therapy
- Cancer Treatment and Pharmacology
- AI in cancer detection
- Platelet Disorders and Treatments
- Computational Drug Discovery Methods
- Gastric Cancer Management and Outcomes
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Indoor and Outdoor Localization Technologies
- RNA modifications and cancer
- Cellular transport and secretion
- Hemophilia Treatment and Research
- Ferroptosis and cancer prognosis
- Inflammatory Biomarkers in Disease Prognosis
- Epigenetics and DNA Methylation
- Vaccine Coverage and Hesitancy
- Cancer Diagnosis and Treatment
VA Boston Healthcare System
2021-2024
Qiqihar Medical University
2017-2024
Shanghai Institute of Microsystem and Information Technology
2006-2024
Boston University
2022-2024
Shanghai Electric (China)
2024
University of Edinburgh
2024
Yanshan University
2024
China Medical University
2016-2023
First Hospital of China Medical University
2016-2023
Case Western Reserve University
2017-2023
Pancreatic cancer is an aggressive disease that typically presents late with poor outcomes, indicating a pronounced need for early detection. In this study, we applied artificial intelligence methods to clinical data from 6 million patients (24,000 pancreatic cases) in Denmark (Danish National Patient Registry (DNPR)) and 3 (3,900 the United States (US Veterans Affairs (US-VA)). We trained machine learning models on sequence of codes histories tested prediction occurrence within incremental...
YN968D1 (Apatinib) selectively inhibits phosphorylation of VEGFR-2 and tumor angiogenesis in mice model. The study was conducted to determine the maximum tolerated dose (MTD), safety profile, pharmacokinetic variables, antitumor activity advanced solid malignancies.This dose-escalation according Chinese State Food Drug Administration (SFDA) recommendations patients with tumors MTD for orally administered apatinib. Doses continuously apatinib were escalated from 250 mg. Treatment continued...
The abnormal m6A modification caused by modulators is a common feature of various tumors; however, little known about which modulator plays the most important role in triple-negative breast cancer (TNBC). In this study, when analyzing influence (METTL3, METTL14, WTAP, FTO, and ALKBH5) on prognosis cancer, especially TNBC using several on-line databases, methyltransferase-like 3 (METTL3) was found to have low expression closely associated with short-distance-metastasis-free survival TNBC....
Abstract Background: Coronavirus disease 2019 (COVID-19) hospitalization definitions do not include a severity assessment. Thus, we sought to identify simple and objective mechanism for identifying hospitalized severe cases measure the impact of vaccination on trends. Methods: All admissions Veterans’ Affairs (VA) hospital, where routine inpatient screening is recommended, between March 1, 2020, November 22, 2021, with laboratory-confirmed acute respiratory coronavirus virus 2 (SARS-CoV-2)...
Computation-based drug-repurposing/repositioning approaches can greatly speed up the traditional drug discovery process. To date, systematic and comprehensive computation-based to identify validate drug-repositioning candidates for epithelial ovarian cancer (EOC) have not been undertaken. Here, we present a novel strategy that combines computational system (DrugPredict) with biological testing in cell lines order rapidly EOC. DrugPredict exploited unique repositioning opportunities rendered...
In a subset of psoriasis (PsO) and psoriatic arthritis (PsA) patients, the skin and/or joint lesions appear to generate biologically significant systemic inflammation. Red cell distribution width (RDW) mean platelet volume (MPV) are readily available clinical tests that reflect responses bone marrow plasma thrombogenicity (e.g., inflammation), can be markers for major adverse cardiac events (MACE). We aimed evaluate if RDW MPV may employed as inexpensive, routinely obtained biomarkers in...
The p38 MAPK and heat shock protein 27 (hsp27) form a signaling complex with serine/threonine kinase Akt MAPK-activated kinase-2 (MK2), which plays an important role in controlling stress-induced apoptosis reorganizing actin cytoskeleton. However, regulation of the is poorly understood. In this study, interaction between hsp27 was visualized single living L929 cells using fluorescence resonance energy transfer technology, while their association examined by immunoprecipitation analysis....
Cancer origin determination combined with site-specific treatment of metastatic cancer patients is critical to improve patient outcomes. Existing pathology and gene expression-based techniques often have limited performance. In this study, we developed a deep neural network (DNN)-based classifier for prediction using DNA methylation data 7,339 18 different origins from The Genome Atlas (TCGA). This DNN model was evaluated four strategies: (1) when by 10-fold cross-validation, it achieved an...
Epidermal growth factor receptor-tyrosinase kinase inhibitor (EGFR-TKI) resistance is the major obstacle in treatment of lung adenocarcinoma (LUAD) patients harboring EGFR-sensitive mutations. However, long non-coding RNAs (lncRNAs) related to EGFR-TKIs and their functional mechanisms are still largely unknown. This study aimed investigate role regulatory mechanism lncRNA APCDD1L-AS1 icotinib cancer.Molecular approaches including qRT-PCR, MTT assay, colony formation, RNA interference cell...
Inhibitors targeting integrins (ITGs) are applied as a novel strategy for cancers including lung cancer; however, the heterogeneity of ITG subunits might explain why ITG-targeted inhibitors only show limited efficacy small group cancer patients.RNA-Seq data adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) patients were obtained from TCGA database. Cox regression analysis was performed to construct prognostic signature generate nomogram combined with pathologic stages (pStage). GEO...
The use of antidepressants in major depressive disorder (MDD) has been reported to influence long-term risk Alzheimer's disease (AD) and AD-related dementias (AD/ADRD), but studies are conflicting.
In this paper, we propose GROUP, a grid-clustering routing protocol that provides scalable and efficient packet for large-scale wireless sensor networks. The sink proactively, dynamically randomly builds cluster grid structure in GROUP. Only small part of all nodes will participate election heads. GROUP can distribute the energy load among sensors network, provide in-network processing support to reduce amount information must be transmitted sink. We have evaluated performance through...
LMAN1 (ERGIC-53) is a key mammalian cargo receptor responsible for the export of subset glycoproteins from endoplasmic reticulum. Together with its soluble coreceptor MCFD2, transports coagulation factors V (FV) and VIII (FVIII). Mutations in or MCFD2 cause genetic bleeding disorder combined deficiency FV FVIII (F5F8D). The carbohydrate recognition domain (CRD) binds to both glycoprotein Ca(2+)-dependent manner. To understand biochemical basis regulation binding cargo, we solved crystal...
The unicellular green alga, Chlamydomonas reinhardtii, is a classic model for studying flagella and biofuel. However, precise gene editing, such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) CRISPR-associated protein (Cas9) system, not widely used in this organism. Screening of random insertional mutant libraries by polymerase chain reaction provides an alternate strategy to obtain null mutants individual gene. But building, screening, maintaining library was...
Succinylation is a newly discovered and multienzyme-regulated post-translational modification (PTM) that associated with the initiation progression of cancer. Currently, no systematic analyses on role succinylation regulators in tumors have been reported. In this study, we performed comprehensive pan-cancer analysis four well-known (CPT1A, KAT2A, SIRT5, SIRT7). We found these played specific critical roles prognosis clear cell renal carcinoma (ccRCC). constructed risk score (RS) based two...
Active neutrophils are important contributors to Alzheimer's disease (AD) pathology through the formation of capillary stalls that compromise cerebral blood flow (CBF) and aberrant neutrophil signaling advances progression. The lymphocyte ratio (NLR) is a proxy neutrophil-mediated inflammation, higher NLR found in persons diagnosed with clinical AD. objective this study was investigate whether increased older adults independently associated risk subsequent dementia.