A5101599428- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Cell death mechanisms and regulation
- Cancer Mechanisms and Therapy
- Immune Cell Function and Interaction
- interferon and immune responses
- Cancer-related Molecular Pathways
- Immunotherapy and Immune Responses
- Colorectal Cancer Treatments and Studies
- Cancer, Lipids, and Metabolism
- Gastric Cancer Management and Outcomes
- NF-κB Signaling Pathways
- Circular RNAs in diseases
- Cancer Cells and Metastasis
- Caveolin-1 and cellular processes
- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
China Medical University
2016-2025
First Hospital of China Medical University
2016-2025
Ministry of Education of the People's Republic of China
2020-2025
Affiliated Hospital of Hebei University
2022-2023
Qilu Hospital of Shandong University
2021-2023
Shenyang Center for Disease Control and Prevention
2022
Cedars-Sinai Medical Center
2019-2021
Shandong University
2016-2021
China Pharmaceutical University
2016-2020
Academy of Military Medical Sciences
2020
Programmed death-ligand 1 (PD-L1) is an immunosuppressor that plays important role in cancer treatments. Although majority of the studies demonstrated PD-L1 expression was regulated by cellular intrinsic and extrinsic controls, IFN-γ a key molecule control, other imply cytokines play roles expression. In this study, we investigated regulation chemokine signaling pathway gastric (GC) cells.Bioinformatics used to explore PD-L1-related genes GC propose hypothesis. CXCR3 were detected western...
Insulin-like growth factor I (IGF-I) can induce epithelial mesenchymal transition (EMT) in many tumors; however, the molecular mechanism by which this occurs is not clearly understood. Additionally, little known about involvement of IGF-I gastric cancer. Two cancer cell lines were treated with to EMT and levels transcription ZEB2 microRNA-200c (miR-200c) measured. Cells Akt/ERK inhibitors investigate role these pathways IGF-I-mediated EMT. Transfection shRNA plasmids was used silence...
Anti-PD-1/PD-L1 therapies have demonstrated prominent clinical effects in the treatment of non-small cell lung cancer (NSCLC). However, limited understanding regulatory mechanisms PD-L1 has become one biggest challenges for further improving efficacy. In this study, we observed that wild-type EFGR lines A549 and H460, ubiquitin ligases Cbl-b c-Cbl inhibit by inactivating STAT, AKT, ERK signaling. MiR-181a miR-940 were screened validated to target c-Cbl, respectively. Furthermore, NSCLC...
Anti-PD-1 therapy has been approved for cancer treatment. However, the response rate is unsatisfactory. The expression of PD-L1 in tumor tissues unreliable to predict treatment response. Recent studies have suggested that exosomal not only exerts immunosuppressive effects but also plays a significant role development microenvironment. Thus, present study aims investigate improving its predictive value and efficacy. A total 44 patients advanced tumors several types, treated with anti-PD-1...
Abnormal RNA m6A methylation is known to lead the occurrence and progression of multiple cancers including gastric cancer (GC). However, integrative effects all regulators on GC prognosis are unclear. Our research aimed globally analyze values 33 in by univariate multivariate Cox regression analyses. Among regulators, fat mass obesity-associated protein (FTO), an demethylase, was identified as a key prognostic risk factor overall survival (OS) patients. It found that FTO could promote cell...
MicroRNAs (miRNAs) are a class of non-protein-coding small RNAs with the capacity to regulate fundamental biological processes essential for cancer initiation and progression. In present study, we analyzed miRNA expression levels between multidrug-resistant gastric carcinoma cell line SGC7901/ADR its parent SGC7901 using microarray. MiR-103/107 was downregulated compared parental cells. Overexpression miR-103/107 sensitized cells doxorubicin (DOX), as demonstrated by in vitro vivo drug...
The American Joint Committee on Cancer (AJCC) staging system is insufficiently prognostic for operable gastric cancer patients; therefore, complementary factors are under intense investigation. Although the focus immune markers, impact of a single factor minimal, due to complex antitumor responses. A more comprehensive evaluation may engender accurate predictions. We analyzed by immunohistochemical staining in two independent cohorts. association with patients' survival was Kaplan-Meier...
Although the cytotoxic chemotherapeutic agent 5-fluorouracil (5-FU) is generally considered to directly kill cancer cells and exert immunostimulatory effects in advanced gastric cancer, accumulating evidence indicates that it upregulates expression of PD-L1, a representative immune checkpoint blockade molecule involved negative regulation response. It was reported exosomes could transfer functional PD-L1 locally distantly suppress antitumor However, whether 5-FU alters exosomal induces...
Epidermal growth factor receptor-tyrosinase kinase inhibitor (EGFR-TKI) resistance is the major obstacle in treatment of lung adenocarcinoma (LUAD) patients harboring EGFR-sensitive mutations. However, long non-coding RNAs (lncRNAs) related to EGFR-TKIs and their functional mechanisms are still largely unknown. This study aimed investigate role regulatory mechanism lncRNA APCDD1L-AS1 icotinib cancer.Molecular approaches including qRT-PCR, MTT assay, colony formation, RNA interference cell...
Abstract Head neck squamous cell carcinoma (HNSCC) is one of the most common malignant tumors which ranks sixth incidence in world. Although treatments for HNSCC have improved significantly recent years, its recurrence rate and mortality remain high. Myosin genes been studied a variety tumors, however role has not elucidated. GSE58911 GSE30784 gene expression profile analysis were performed to detect dys-regulated myosin HNSCC. The Cancer Genome Atlas (TCGA) database was used verify study...
Microsatellite instability-high (MSI-H) metastatic colorectal cancer (CRC) patients are the dominant population in immune checkpoint blockade treatments, while more than half of them could not benefit from single-agent immunotherapy. We tried to identify biomarker MSI-H CRC and explore its role mechanism anti-PD-1 treatments. Tumor-specific MHC-II was linked a better response CD74 promoted assembly transport HLA-DR dimers. The characteristic gene screened by data analysis single-cell bulk...
The epithelial-to-mesenchymal transition (EMT) is a well-known prerequisite for cancer cells to acquire the migratory and invasive capacity, subsequently metastasize. Bufalin one of major active components traditional Chinese medicine Chan Su, accumulating evidence has shown its anticancer effect in multipe types cancer. However, role bufalin transforming growth factor‑β (TGF‑β)‑induced EMT migration remains unclear. In present study, on TGF‑β‑induced was investigated human lung A549 cells....
Multiple drug resistance (MDR) and metastasis are two major factors that contribute to the failure of cancer treatment. However, relationship between MDR has not been characterized. Additionally, role E3 ubiquitin ligase Cbl-b in gastric breast is well known. In present study, we found cells possess a typical mesenchymal phenotype enhanced cell migration capacity. poorly expressed cells. adenocarcinoma tissues, patients with low expression were more likely have tumor invasion (P = .016)...
Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM also possesses ER-independent antitumor activity through an unclear mechanism. The present study investigated anti-tumor mechanism on mesenchymal triple-negative (TNBC).The inhibitory effect tumor migration metastasis was analyzed transwell chamber in vitro murine xenograft model vivo....
Breast cancer is the most lethal malignancy in women. N-acetylgalactosaminyltransferase 6 (GALNT6) an enzyme which mediates initial step of mucin-type O-glycosylation, and has been reported to be involved mammary carcinogenesis. However, molecular mechanism GALNT6 breast metastasis not fully explored. In this study, based on online database analyses tissue microarrays, overall survival (OS) patients with high expression was found shorter than those low GALNT6. Also, positively correlated...
As a vital feature of the microenvironment, hypoxia, especially long-term is known to promote metastasis and lead poor prognosis in solid tumors. Circular RNAs (circRNAs) participate important processes cell proliferation cancers. However, contribution circRNAs under hypoxia obscure. In this study, we aim explore specific functions circHIPK3 hypoxia-promoting gastric cancer (GC). The hypoxic resistant (HRGC) lines established previously, which were tolerant 2% O2 conditions, used as model....
Hypopharyngeal squamous cell carcinoma (HSCC) is a kind of head and neck (HNSCC) with poor prognosis. Metabolic reprogramming may regulate the tumor microenvironment (TME) by adapting quickly to cellular stress regulating immune response, but its role in HSCC has not been reported. We used nCounter ® Pathways Panel investigate metabolic reprogramming, stress, their relationship tissues adjacent normal tissues. Metabolism-related pathways nucleotide synthesis glycolysis were significantly...
Ubiquitination of caspase-8 regulates TNF-related apoptosis-inducing ligand (TRAIL) sensitivity in cancer cells, and the preligand assembly complex plays a role polyubiquitination. However, whether such exists gastric cells its TRAIL-triggered apoptosis is unclear. In this study, DR5, casitas B-lineage lymphoma-b (Cbl-b)/c-Cbl, TRAF2 formed TRAIL-resistant Cbl-b c-Cbl were critical adaptors linking DR5 TRAF2. Treatment with TRAIL induced translocation into DR5-Cbl-b/c-Cbl-TRAF2 to interact...
Bufalin, a cardiotonic steroid isolated from toad venom, has been shown to kill various types of tumor cells. Our previous study showed that triple-negative breast cancer (TNBC) cells were less sensitive bufalin than other cells, but the reason for this lower sensitivity remains unclear. In study, we induced apoptosis in MDA-MB-231 and MCF-7/ADR TNBC cell lines, accompanied by increased miR-155-5p expression. Overexpression promoted proliferation reduced bufalin-induced contrast,...