A5101665484- Acute Myeloid Leukemia Research
- Geological and Geochemical Analysis
- Neutropenia and Cancer Infections
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Acute Lymphoblastic Leukemia research
- Pancreatic and Hepatic Oncology Research
- Neuroblastoma Research and Treatments
- Radioactive element chemistry and processing
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Cells and Metastasis
- Histone Deacetylase Inhibitors Research
- Hemoglobinopathies and Related Disorders
- Geochemistry and Geologic Mapping
- earthquake and tectonic studies
- Metastasis and carcinoma case studies
- Genetic factors in colorectal cancer
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Chronic Myeloid Leukemia Treatments
- Nanoplatforms for cancer theranostics
Liaoning Cancer Hospital & Institute
2019-2025
Renji Hospital
2024
China Medical University
2010-2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
Dalian University of Technology
2024
State Key Laboratory of Chemobiosensing and Chemometrics
2019-2023
Hunan University
2017-2023
Shanghai Jiao Tong University
2023
Affiliated Hospital of Qingdao University
2022
Although induction chemotherapy results in remission many older patients with acute myeloid leukemia (AML), relapse is common and overall survival poor.
Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was to deliver enhanced simultaneously inhibit PTT-induced response. 1-Pyrene methanol utilize synthesize the anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond also facilitate loading on gold nanorod (AuNR)-encapsulated...
The current American Joint Commission on Cancer (AJCC) staging system distinguishes between soft tissue and visceral metastases in advanced (stage IV) melanoma. We sought to verify these criteria identify prognostic variables that could be used evaluate the impact of systemic therapy long-term survival during prior decade.We conducted a retrospective study patients with cutaneous melanoma enrolled clinical trials 1979 1989 at University Texas M.D. Anderson Center. Pretreatment age, sex,...
Single-atom nanozymes (SAzymes) with high catalytic activity exhibit the potential to disequilibrate reactive oxygen metabolic balance in tumor microenvironment (TME), which contains several endogenous reductive substances such as glutathione (GSH). Herein, a novel nano-assembly (CDs@Pt SAs/NCs@DOX) is first constructed using drug-primed platinum (Pt) single-atom or nanocluster Pt loading of 34.8%, exhibits prominent dual enzymatic activities mimic peroxidase (POD) and oxidase (GSHOx). The...
3016 Background: SYSA1801 is a MMAE antibody-drug conjugate (ADC) targeting claudin 18.2 (CLDN18.2), tight junction protein broadly expressed in gastric, pancreatic, and other solid tumors. CLDN18.2 has highly selective cell surface expression profile that limited to normal gastric mucosa, making it promising ADC therapeutic target. shown significant vitro vivo anti-tumor activity multiple lines patient-derived xenografts expressing CLDN18.2. Methods: This an open-label, multi-center, phase...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human cancers. Several studies have reported that carbohydrate antigen 19-9 (CA19-9) level a useful marker for predicting prognosis PDAC after resection. However, cutoff value CA19-9 used to predict varied among these reports. The aims this study were evaluate whether serum significant predictor survival and determine optimal prognosis.A total 120 consecutive patients who underwent surgery potentially resectable primary...
CC-486 (oral azacitidine) is an epigenetic modifier in clinical development for treatment of hematological cancers. This study extended dosing included patients with myelodysplastic syndromes (MDSs), chronic myelomonocytic leukemia (CMML), or acute myeloid (AML). After a pharmacokinetic assessment period, 31 (MDS n = 18, CMML 4, and AML 9) entered phase which they received 300 mg once-daily 21 days repeated 28-day cycles. Median age was 71 years (range: 53-93); 42% were aged ≥75 years. A...
Breast cancer is a common malignant tumor which affects health of women and multidrug resistance (MDR) one the main factors leading to failure chemotherapy. This study was conducted establish paclitaxel-resistant breast cell line nude mice models explore underlying mechanisms MDR.The drug-sensitive MCF-7 (MCF-7/S) exposed in stepwise escalating paclitaxel (TAX) induce resistant MCF-7/TAX. Cell sensitivity drugs growth curves were measured by MTT assay. Changes morphology ultrastructure...
Although the efficacy of tamoxifen (TAM) for breast cancer has been attributed to inducing cell cycle arrest and apoptosis by inhibiting estrogen receptor (ER) signaling, recent evidence indicates that TAM also possesses ER-independent antitumor activity through an unclear mechanism. The present study investigated anti-tumor mechanism on mesenchymal triple-negative (TNBC).The inhibitory effect tumor migration metastasis was analyzed transwell chamber in vitro murine xenograft model vivo....
Aims Describe the characteristics, treatment patterns and outcomes of Chinese patients with unresectable advanced/metastatic (UAM) gastric/gastroesophageal junction adenocarcinoma (GA/GEJA).
AbstractThe discovery of microRNAs (miRNAs) has opened a new avenue for both diagnosis and treatment cancers. Accumulating experimental evidences indicate that miRNAs are aberrantly expressed in different tumor types have critical role tumorigenesis. However, the miRNA expression profile neuroblastoma (NB), one most common cancer forms children, not been well characterized. In present study, we established heterotopic transplant mice model NB employed microarray analysis to identify...
Abstract Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was to deliver enhanced simultaneously inhibit PTT‐induced response. 1‐Pyrene methanol utilize synthesize the anti‐inflammatory prodrug pyrene–aspirin (P‐aspirin) with a cleavable ester bond also facilitate loading on gold nanorod...
The South China Uranium Province (SCUP) contains the largest number of discovered uranium deposits in China. This province includes seven mineralization belts, at Wuyishan, Taoshan–Zhuguang, Chenzhou–Qinzhou, Gan–Hang, Xixia–Luzong, Mufushan–Hengshan, and Xuefengshan–Jiuwandashan. can be classified according to their ore-hosting rocks into four general types: granite-, volcanic-, black-shale-, sandstone-related. These crop out peripheries Cretaceous–Neogene (K–N) redbed basins or are...
Abstract Volcanic-hosted iron deposits of the eastern Awulale metallogenetic belt in Central Asia possess a reserve over 1.2 billion tons ores and constitute one most important basements for high-grade resources China. Skarns are widespread these closely associated with mineralization. The ages skarns unclear, their genesis remains debated, preventing further investigation into metallogenic processes. We focused on garnets nine ore-bearing from three large-scale (Chagangnuoer, Dunde,...
To explore a new model to predict the prognosis of liver cancer based on MRI and CT imaging data.A retrospective study 103 patients with histologically proven hepatocellular carcinoma (HCC) was conducted. Patients were randomly divided into training (n = 73) validation 30) groups. A total 1,217 radiomics features extracted from regions interest MR images each patient. Univariate Cox regression, Spearman's correlation analysis, Pearson's least absolute shrinkage selection operator analysis...
Parenteral azacitidine improves overall survival in higher-risk myelodysplastic syndromes. An oral formulation would allow extended dosing schedules, potentially improving safety and/or efficacy. Two Phase 1 studies evaluated the pharmacokinetics (PK) of subjects with hematologic malignancies. Study different formulations (immediate release tablet [IRT], enteric-coated tablet, and capsule; N = 16). 2 assessed effect food (Part 1; 17) gastric pH modulation omeprazole 2; 14) on PK. Azacitidine...