A5037293083- Pancreatic function and diabetes
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
- Genetics and Neurodevelopmental Disorders
- Nanoplatforms for cancer theranostics
- Nanoparticle-Based Drug Delivery
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Gold and Silver Nanoparticles Synthesis and Applications
- Advanced Sensor and Energy Harvesting Materials
- Electrospun Nanofibers in Biomedical Applications
- Quantum Dots Synthesis And Properties
- CO2 Reduction Techniques and Catalysts
- Adenosine and Purinergic Signaling
- RNA regulation and disease
- Endoplasmic Reticulum Stress and Disease
- Advanced Drug Delivery Systems
- Advanced battery technologies research
- Electrocatalysts for Energy Conversion
- Wound Healing and Treatments
- Ion Transport and Channel Regulation
- Extracellular vesicles in disease
- Diabetes and associated disorders
Shanghai East Hospital
2020-2025
Tongji University
2020-2024
Jilin University
2024
Advanced Research Institute
2020
Center for Excellence in Molecular Cell Science
2020
Chinese Academy of Sciences
2020
Shanghai Institutes for Biological Sciences
2020
Hunan University
2017-2019
University of Shanghai for Science and Technology
2015
Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was to deliver enhanced simultaneously inhibit PTT-induced response. 1-Pyrene methanol utilize synthesize the anti-inflammatory prodrug pyrene-aspirin (P-aspirin) with a cleavable ester bond also facilitate loading on gold nanorod (AuNR)-encapsulated...
Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of diabetes, yet how to achieve functional maturation and protect them against metabolic stresses such as glucotoxicity lipotoxicity remains elusive. Our single-cell RNA-seq analysis reveals that ZnT8 loss function (LOF) accelerates the SC-β cells. As a result, LOF improves glucose-stimulated insulin secretion (GSIS) by releasing negative feedback zinc inhibition on secretion. Furthermore, we demonstrate...
We have fabricated gold nanorod graphitic nanocapsule (AuNR@G) doped poly(vinyl alcohol) (PVA)/chitosan (CS) hydrogels, which possessed highly efficient and stable photothermal antibacterial properties under the irradiation of a near-infrared laser.
Abstract Dysregulated neurite outgrowth and synapse formation underlie many psychiatric disorders, which are also manifested by wolfram syndrome (WS). Whether how the causative gene WFS1 deficiency affects remain elusive. By mirroring human brain development with cerebral organoids, -deficient organoids not only recapitulate neuronal loss in WS patients, but exhibit significantly impaired function associated reduced astrocytes. neurons autonomously delays differentiation altered expressions...
Abstract Pancreatic β-cell failure by WFS1 deficiency is manifested in individuals with wolfram syndrome (WS). The lack of a suitable human model WS has impeded progress the development new treatments. Here, pluripotent stem cell derived pancreatic islets (SC-islets) harboring and mouse β specific Wfs1 knockout were applied to WS. We charted high-resolution roadmap single-cell RNA-seq (scRNA-seq) investigate pathogenesis for failure, revealing two distinct cellular fates along pseudotime...
Abstract Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. Nevertheless, the fundamental mechanism of regulation remains elusive. Here, it is found that elevated zinc transportation causes excessive in pancreatic cells diabetes. With gene‐edited human embryonic stem cell‐derived (SC‐β cells) and primary islets, results reveal initiates integrated response (ISR), ultimately leads death. By contrary, genetic abolishment shields from exacerbated endoplasmic...
Abstract Photothermal therapy (PTT) has been extensively developed as an effective approach against cancer. However, PTT can trigger inflammatory responses, in turn simulating tumor regeneration and hindering subsequent therapy. A therapeutic strategy was to deliver enhanced simultaneously inhibit PTT‐induced response. 1‐Pyrene methanol utilize synthesize the anti‐inflammatory prodrug pyrene–aspirin (P‐aspirin) with a cleavable ester bond also facilitate loading on gold nanorod...
Type 2 diabetes (T2D) is characterized by the malfunction of pancreatic β cells. Susceptibility and pathogenesis T2D can be affected multiple factors, including sex differences. However, mechanisms underlying differences in susceptibility remain unclear. Using single-cell RNA sequencing (scRNA-seq), we demonstrate presence sexually dimorphic transcriptomes mouse a high-fat diet-induced model, identified sex-dependent altered genes, suggesting sex-based pathological T2D. Furthermore, based on...
Adult mammals have limited capacity to regenerate functional cells. Promisingly, in vivo transdifferentiation heralds the possibility of regeneration by lineage reprogramming from other fully differentiated However, process is poorly understood. Using pancreatic β cell as a paradigm, we performed single-cell transcriptomic study adult mouse acinar cells induced unsupervised clustering analysis and trajectory construction, uncovered that fate remodeling was linear at initial stage...
Conductive hydrogels have garnered significant attention in the realm of future flexible electronic devices due to their properties such as flexibility, electrical conductivity, frost resistance, and biocompatibility. However, integration numerous functional applications biomedical field still presents notable challenges. In this research, a rigid hard-structured network was formed by cross-linking gallic acid grafted chitosan (CS–GA) tannic (TA) with poly(vinyl alcohol) (PVA) through...
Abstract Type 2 diabetes (T2D), characterized by malfunction of pancreatic β cells, is affected multiple cues including sex differences. Nevertheless, mechanisms differences in type susceptibility and pathogenesis remain unclear. Using single-cell RNA sequencing (scRNA-seq) technology, we showed that sexual dimorphism transcriptome exists mouse cells. Our analysis further revealed the existence sex-dependent altered genes high fat diet induced T2D model, suggesting divergences pathological...
Type 2 diabetes, characterized by malfunction of pancreatic β cells, is affected multiple cues including sex differences. Nevertheless, mechanisms differences in type diabetes susceptibility and pathogenesis remain unclear. Using single-cell RNA sequencing (scRNA-seq) technology, we showed that sexual dimorphism transcriptome exists both mouse human differs significantly under diabetic condition. Our analysis further revealed the existence sex-dependent altered genes mice beings, suggesting...
Abstract Human embryonic stem cells (hESCs) derived β (SC-β cells) hold great promise for diabetes treatment, yet how to achieve functional maturation of these SC-β and protect them against metabolic stresses such as glucotoxicity lipotoxicity remain elusive. By single cell RNA-seq pseudotime analysis, we revealed that ZnT8 is involved in process its loss function (LOF) accelerates cells. As a result, LOF improves glucose-stimulated insulin secretion (GSIS) enhances proinsulin conversion...