A5103027495- Polymer Surface Interaction Studies
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic function and diabetes
- Hemostasis and retained surgical items
- CRISPR and Genetic Engineering
- Immune Response and Inflammation
- Pluripotent Stem Cells Research
- Chemokine receptors and signaling
- Muscle and Compartmental Disorders
- HIV Research and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Protein purification and stability
- Silk-based biomaterials and applications
- Immunotherapy and Immune Responses
- Nitric Oxide and Endothelin Effects
- Municipal Solid Waste Management
- 3D Printing in Biomedical Research
- Microbial Natural Products and Biosynthesis
- biodegradable polymer synthesis and properties
- Adenosine and Purinergic Signaling
- Nanoparticle-Based Drug Delivery
- Genetics and Neurodevelopmental Disorders
- Cardiac and Coronary Surgery Techniques
- Fungal Biology and Applications
- Intracranial Aneurysms: Treatment and Complications
Southern Medical University
2023-2025
Southwest Jiaotong University
2012-2025
Shanghai East Hospital
2020-2025
Advanced Research Institute
2020
Tongji University
2020
Chinese Academy of Tropical Agricultural Sciences
2012
Harvard University
1999
Osaka University
1998
Beth Israel Deaconess Medical Center
1998
The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration pre-B cell proliferation. receptor for CXCR4, also functions as a coreceptor T-tropic HIV-1 entry. We find that mice deficient CXCR4 die perinatally display profound defects in the nervous systems. CXCR4-deficient have severely reduced B-lymphopoiesis, myelopoiesis fetal liver, virtual absence bone marrow. However, T-lymphopoiesis unaffected. Furthermore,...
Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of diabetes, yet how to achieve functional maturation and protect them against metabolic stresses such as glucotoxicity lipotoxicity remains elusive. Our single-cell RNA-seq analysis reveals that ZnT8 loss function (LOF) accelerates the SC-β cells. As a result, LOF improves glucose-stimulated insulin secretion (GSIS) by releasing negative feedback zinc inhibition on secretion. Furthermore, we demonstrate...
Proteins, cells and bacteria adhering to the surface of medical devices can lead thrombosis infection, resulting in significant clinical mortality. Here, we report a zwitterionic polymers-armored amyloid-like protein engineering strategy called as "armored-tank" for dual functionalization devices. The is realized by decoration partially conformational transformed LZM (PCTL) assembly through oxidant-mediated process, followed armoring with super-hydrophilic poly-2-methacryloyloxyethyl...
Mimicking the nitric oxide (NO)-release and glycocalyx functions of native vascular endothelium on cardiovascular stent surfaces has been demonstrated to reduce in-stent restenosis (ISR) effectively. However, practical performance such an endothelium-mimicking is strictly limited by durability both NO release bioactivity component. Herein, we present a mussel-inspired amine-bearing adhesive coating able firmly tether NO-generating species (e.g., Cu-DOTA coordination complex) glycocalyx-like...
Abstract Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. Nevertheless, the fundamental mechanism of regulation remains elusive. Here, it is found that elevated zinc transportation causes excessive in pancreatic cells diabetes. With gene‐edited human embryonic stem cell‐derived (SC‐β cells) and primary islets, results reveal initiates integrated response (ISR), ultimately leads death. By contrary, genetic abolishment shields from exacerbated endoplasmic...
One new compound named amauroamoienin (<b>1</b>), together with thirteen known compounds (<b>2</b>–<b>14</b>), was isolated from the EtOAc extract of <i>Amauroderma amoiensis</i>. The structures these were elucidated by analysis 1D and 2D spectroscopic data MS technique. bioassays inhibitory activities isolates against acetylcholinesterase evaluated, <b>1, 3</b>, <b>5</b> exhibited activities.
Pallets sharing system is a complex network system. Pallet the carrier to improve efficiency of logistics, reduce cargo damage and ensure transport safety, pallets through rental recycle method used establish what will significantly logistics systems. Analyzing Reverse Logistics Network structure pallet recycling, taking into account capacity uncertain factors each sites, paper established function model. The numerical examples show effectiveness model, draw some meaningful conclusions.
Abstract Human embryonic stem cells (hESCs) derived β (SC-β cells) hold great promise for diabetes treatment, yet how to achieve functional maturation of these SC-β and protect them against metabolic stresses such as glucotoxicity lipotoxicity remain elusive. By single cell RNA-seq pseudotime analysis, we revealed that ZnT8 is involved in process its loss function (LOF) accelerates cells. As a result, LOF improves glucose-stimulated insulin secretion (GSIS) enhances proinsulin conversion...
Thrombus formation and tissue embedding significantly impair the clinical efficacy retrievability of temporary interventional medical devices. Herein, we report an insect sclerotization-inspired antifouling armor for tailoring devices with durable resistance to protein adsorption following protein-mediated complications. By mimicking phenol-polyamine chemistry assisted by phenol oxidases during sclerotization, develop a facile one-step method crosslink bovine serum albumin (BSA) oxidized...