A5103253845- Cancer, Hypoxia, and Metabolism
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Complement system in diseases
- Angiogenesis and VEGF in Cancer
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- Inflammatory mediators and NSAID effects
- Autophagy in Disease and Therapy
- Genetics and Neurodevelopmental Disorders
- Adenosine and Purinergic Signaling
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Renal cell carcinoma treatment
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Cancer, Stress, Anesthesia, and Immune Response
- Monoclonal and Polyclonal Antibodies Research
- Cervical Cancer and HPV Research
- Circular RNAs in diseases
- TGF-β signaling in diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Shanghai East Hospital
2024-2025
East China University of Science and Technology
2024
Harbin Medical University
2012-2023
Third Affiliated Hospital of Harbin Medical University
2012-2023
Tongji University
2018-2021
Zero to Three
2012
Southern Medical University
2008-2010
Nanfang Hospital
2009-2010
Abstract Background Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We previously reported that over-expression of an inhibitor DNA binding/differentiation 1 (Id1) in EPCs can enhance EPC proliferation, migration, adhesion. In this study, we investigated the role Id1 patients with ovarian cancer underlying signaling pathway. Methods Circulating from 22 15 healthy control subjects were cultured. matrix metalloproteinase-2 (MMP-2) expression analyzed by...
Vitamin D deficiency is identified as a risk factor for gestational diabetes mellitus (GDM). Forkhead box class O1 (FoxO1) closely related to GDM; however, the role of vitamin and underlying pathogenesis GDM has not been elucidated. Serum level was detected using chemiluminescence immunoassay. FOXO1 expression examined Real-time polymerase chain reaction (PCR), western blot immunocytochemistry analysis. Apoptosis cells assessed by flow cytometry. Mitochondrial function via reactive oxygen...
Abstract Background Circulating bone marrow-derived endothelial progenitor cells (EPCs) have been reported to participate in tumor angiogenesis and growth; however, the role of circulating EPCs progression is controversial. The ovarian cancer has not yet investigated. Methods number peripheral blood 25 healthy volunteers 42 patients with was determined by flow cytometry. were defined co-expression CD34 vascular growth factor receptor 2 (VEGFR2). In addition, we VEGFR2 mRNA levels real-time...
ATP citrate lyase (ACLY) is a key enzyme of lipogenesis in cells. However, ACLY expression renal cell carcinoma (RCC) and its association with clinicopathological parameters remain unclear. The present study aimed to evaluate levels RCC adjacent normal tissues. This included 33 patients clear (ccRCC). protein was assayed using immunohistochemistry western blotting methods. mRNA determined by reverse transcription‑quantitative polymerase chain reaction. Serum concentrations were measured the...
Abstract Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. Nevertheless, the fundamental mechanism of regulation remains elusive. Here, it is found that elevated zinc transportation causes excessive in pancreatic cells diabetes. With gene‐edited human embryonic stem cell‐derived (SC‐β cells) and primary islets, results reveal initiates integrated response (ISR), ultimately leads death. By contrary, genetic abolishment shields from exacerbated endoplasmic...
Abstract Background Endothelial progenitor cells (EPCs) contribute to tumor angiogenesis and growth. We aimed determine whether inhibitors of differentiation 1 (Id1) were expressed in circulating EPCs patients with ovarian cancer, Id1 could mediate mobilization recruitment, and, if so, what underlying signaling pathway it used. Methods Circulating cultures from 25 cancer 20 healthy control subjects. integrin α4 expression analyzed by real-time reverse transcription-polymerase chain reaction...
COX-2 is involved in several pathological processes. The action of on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects CAOV-3 viability migration, moreover proliferation CAOV-3, then ascertained roles PI3-k/Akt these results showed that increased cells viability, migration augment number CAOV-3. LY294002 could reduce induce proliferation. These data indicate promote via pathway.
Decay-accelerating factor (DAF) and membrane cofactor protein (MCP) are the key molecules involved in cell protection against autologus complement, which restricts action of complement at critical stages cascade reaction. The cooperative effect DAF MCP on survival human cervical cancer (ME180) has not been demonstrated. In this study we applied, for first time, short hairpin RNA (shRNA) to knock down expression with aim exploiting more effectively tumor damage. Meanwhile, investigated...
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The globular heads of the human C1q receptor (gC1qR) are multi-compartmental and multi-functional cellular proteins. list biological responses mediated by gC1qR includes growth perturbation morphological abnormalities, along with initiation apoptosis. However, effects on apoptosis cervical squamous carcinoma cells (C33a SiHa) have not been demonstrated.Here, tissues were examined for expression using real-time PCR Western blot analysis. Apoptotic death C33a SiHa was assessed flow cytometric...
Human papillomavirus type-16 (HPV-16) E2 protein acts as a transcriptional modulator and plays key role in regulating many biological responses. The purpose of this study was to investigate the relationship between HPV-16 E2, receptor for globular heads human C1q (gC1qR) gene expression, mitochondrial dysfunction apoptosis regulation cervical squamous carcinoma cells (C33a SiHa).HPV-16 gC1qR expression examined using real-time PCR western blot analysis. Apoptosis C33a SiHa assessed by flow...
Objectives: The purpose of this study was to evaluate the clinical significance genomic amplification human telomerase RNA gene (TERC) for cervical cancer screening and explore whether it can serve as a biomarker improve specificity papillomavirus (HPV) DNA testing screening. Methods: One hundred twenty women, including 20 cases normal (control), 14 intraepithelial neoplasia grade I (CIN I), 35 CIN II, 36 III, 15 squamous diagnosed by histopathologic evaluation, were subjected cytopathologic...
Abstract Background The globular heads of the human C1q receptor (gC1qR) localize predominantly to mitochondrial matrix. gC1qR mediates many biological responses, including growth perturbation, morphological abnormalities and initiation apoptosis. purpose this study was investigate relationship between dysfunction, p53 status expression regulation apoptosis in cervical squamous carcinoma cells (C33a SiHa). Methods Here, examined tissues using real-time PCR Western blot analysis. Apoptotic...
Obesity-related muscular dysfunction and relative muscle atrophy affect an increasing number of people. Elucidating the molecular mechanisms skeletal cell development growth may contribute to maintenance mass in obesity. Fatty acid translocase (FAT/CD36), as a long-chain fatty transport protein, is crucial for lipid metabolism signaling. CD36 known function myogenic differentiation, whether it affects proliferation cells underlying remain unclear. In this study, effect deficiency on...
Introduction: This study investigates the clinical significance of galectin-1 expression in carcinoma tissues, plasma, and lymphocytes patients with clear-cell renal cell (RCC).Methods: Galectin-1 was investigated, using immunohistochemistry, 91 RCC tissue sections, five angioleiolipomas three oncocytomas sections. As controls, normal sections adjacent to each tumour six benign were examined. Plasma galectin- 1 levels as measured by ELISA compared 39 patients. Proportions expressing CD4+...
Abstract Background: Pole2 gene is a subunit of DNA polymerases localized in the nucleus, which commonly present repair. The effect pole2 renal cell carcinoma (RCC) still remain unclear. Here we investigate its clinical significance, function RCC cells and possible mechanism effect. Methods: Using TCGA database, identified that up-regulation associated with poor prognosis ccRCC. We analyzed association between expression T stage or Fuhrman grade. Thus, effects down-regulation on...
Deucravacitinib is a selective allosteric inhibitor of tyrosine kinase 2 (TYK2) recently approved by the FDA for treatment plaque psoriasis. We discovered that this compound induces proteasomal degradation YAP1, downstream effector Hippo signaling pathway, in human glioblastoma (GBM) cells (U-87 MG). This independent canonical which offers clues to alternative mechanisms YAP1 regulation.
Abstract Obesity, a growing global health concern, is closely linked to depression. However, the neural mechanism of association between obesity and depression remains poorly understood. In this study, neural‐specific WFS1 deficiency exacerbates vicious cycle in mice fed high‐fat diet (HFD), positioning as crucial factor cycle. Through human pluripotent stem cells (hESCs) differentiation, it demonstrated that regulates Zn 2+ homeostasis apoptosis progenitor (NPCs) cerebral organoids by...
Autophagy is a conserved catabolic process crucial for maintaining cellular homeostasis and has emerged as promising therapeutic target many diseases. Mechanistically novel small-molecule autophagy regulators are highly desirable from pharmacological point of view. Here, we report the macroautophagy-inhibitory effect hapalindole Q, member structurally intriguing but biologically understudied family indole terpenoids. This compound promotes noncanonical degradation Yes-associated protein 1...
<b><i>Objectives:</i></b> Human papillomavirus 16 (HPV 16) E2 is a transcriptional regulator that plays key role in regulating variety of biological responses. Hematopoietic cell-specific protein 1-related X-1 (HAX-1) mitochondrial membrane protein, and the HAX-1 gene involved occurrence, growth, invasion, metastasis various human malignant tumors. The purpose this study was to investigate relationships among HPV E2, gene, underlying intracellular apoptotic mechanism...