A5101739409- Pancreatic function and diabetes
- Spine and Intervertebral Disc Pathology
- Reproductive Biology and Fertility
- Cancer Mechanisms and Therapy
- Renal and related cancers
- Tendon Structure and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Ion channel regulation and function
- Healthcare and Venom Research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Endoplasmic Reticulum Stress and Disease
- Genetics and Neurodevelopmental Disorders
- Osteoarthritis Treatment and Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Neurofibromatosis and Schwannoma Cases
- Hippo pathway signaling and YAP/TAZ
- Musicians’ Health and Performance
- Inflammatory Biomarkers in Disease Prognosis
- Nanoplatforms for cancer theranostics
- Pharmaceutical and Antibiotic Environmental Impacts
- Quinazolinone synthesis and applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Genomic variations and chromosomal abnormalities
Tongji University
2021-2025
Sichuan Agricultural University
2024-2025
Ministry of Agriculture and Rural Affairs
2024-2025
Shanghai East Hospital
2023-2025
Anhui University of Science and Technology
2025
First Affiliated Hospital of GuangXi Medical University
2022-2024
Guangxi Medical University
2012-2024
Stomatology Hospital
2024
Sun Yat-sen University
2024
Hunan Normal University
2023
Abstract Literature-described targets of herbal ingredients have been explored to facilitate the mechanistic study herbs, as well new drug discovery. Though several databases provided similar information, majority them are limited literatures before 2010 and need be updated urgently. HIT 2.0 was here constructed latest curated dataset focusing on Herbal Ingredients’ Targets covering PubMed 2000–2020. Currently, hosts 10 031 compound-target activity pairs with quality indicators between 2208...
Abstract Pancreatic β-cell failure by WFS1 deficiency is manifested in individuals with wolfram syndrome (WS). The lack of a suitable human model WS has impeded progress the development new treatments. Here, pluripotent stem cell derived pancreatic islets (SC-islets) harboring and mouse β specific Wfs1 knockout were applied to WS. We charted high-resolution roadmap single-cell RNA-seq (scRNA-seq) investigate pathogenesis for failure, revealing two distinct cellular fates along pseudotime...
The motility of sperm decreases following cryopreservation, which is closely associated with mitochondrial function. However, the alterations in metabolism after freezing goats remain unclear. This experiment aimed to investigate impact ultra-low temperature on goat sperm's energy and its potential correlation motility. results revealed that exhibited vacuolization, reduced matrix density, significantly decreased levels high-membrane mitochondria adenosine triphosphate content, accompanied...
Glufosinate (GLUF) and glyphosate (GLY) are nonselective phosphorus-containing amino acid herbicides that widely used in agricultural gardens noncultivated areas. These give rise to a number of key metabolites, with 3-methyl phosphinicopropionic (MPPA), N-acetyl glufosinate (N-acetyl GLUF), aminomethyl phosphonic (AMPA), AMPA), GLY), N-methyl (N-methyl GLY) as the major metabolites obtained from GLUF GLY. Extensive use these may lead their increased presence environment, especially aquatic...
ABSTRACT The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational medicine. In case prepubertal girls, clinical challenge is pronounced, as ovarian tissue cryopreservation‐though promising‐remains an experimental technique necessitating rigorous scientific validation to guarantee developmental potential preserved materials facilitate broader adoption. To address these knowledge gaps,...
Abstract Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. Nevertheless, the fundamental mechanism of regulation remains elusive. Here, it is found that elevated zinc transportation causes excessive in pancreatic cells diabetes. With gene‐edited human embryonic stem cell‐derived (SC‐β cells) and primary islets, results reveal initiates integrated response (ISR), ultimately leads death. By contrary, genetic abolishment shields from exacerbated endoplasmic...
CD47-blocking antibody is a well-known potential drug for tumor immunotherapy. However, it unclear whether can protect against metabolic disorders. We report that high-fat diet (HFD)-induced obesity increases CD47 expression, while exercise downregulates in skeletal muscle. Administration of mice prevents HFD-induced weight gain and glucose intolerance, enhances capacity, improves body composition muscle mitochondrial function. Mechanistically, the protective effects conferred by are...
S-Detect is a computer-assisted, artificial intelligence-based system of image analysis that has been integrated into the software ultrasound (US) equipment and capacity to independently differentiate between benign malignant focal breast lesions. Since revision upgrade in both imaging-reporting data (BI-RADS) US lexicon 2013, evidence supports improved accuracy specificity radiologists' assessment lesions accumulated. However, such using technology distinguish from with diameter no greater...
Adult mammals have limited capacity to regenerate functional cells. Promisingly, in vivo transdifferentiation heralds the possibility of regeneration by lineage reprogramming from other fully differentiated However, process is poorly understood. Using pancreatic β cell as a paradigm, we performed single-cell transcriptomic study adult mouse acinar cells induced unsupervised clustering analysis and trajectory construction, uncovered that fate remodeling was linear at initial stage...
Our previous study found that the intravesical perfusion of metformin has excellent inhibitory effects against bladder cancer (BC). However, this administration route allows drug to be diluted and excreted in urine. Therefore, increasing adhesion mucosal layer may prolong retention time increase pharmacological activity. It is well known chitosan (Cs) a strong layer. Thus, established novel formulation enhance its antitumor activity by extending time. In research, we prepared Cs freeze-dried...
Previous studies have shown that the vitrification of metaphase II (MII) oocytes significantly represses their developmental potential. Abnormally increased oxidative stress is probable factor; however, underlying mechanism remains unclear. The walnut-derived peptide TW-7 was initially isolated and purified from walnut protein hydrolysate. Accumulating evidences implied a powerful antioxidant, while its prospective application in oocyte cryopreservation has not been reported. Here, we found...
Lysophosphatidic acid (LPA) is a bioactive lipid mediator involved in tumour progression, cell invasion and metastasis. The mechanism of action LPA the invasive metastatic capacity human hepatocellular carcinoma (HCC) not fully understood. This study investigated effects on HCC induction matrix metalloproteinase (MMP) -2 -9.LPA receptor levels lines were detected by Western blot analysis; was analysed Transwell® system. blocker Ki16425 used to determine whether dependent. Expression MMP2...
Bone Marrow Mesenchymal Stem Cells (BMSCs), multidirectional cells with self-renewal capacity, can differentiate into many cell types and play essential roles in tissue healing regenerative medicine. Cell experiments vivo research animal models have shown that BMSCs repair degenerative discs by promoting proliferation expressing Extracellular Matrix (ECM) components, such as type II collagen protein-polysaccharides. Delaying or reversing the Intervertebral Disc Degeneration (IDD) process at...
Our previous study found that intravesical perfusion metformin has excellent inhibitory effects against bladder cancer (BC). However, this administration route allows the drug to be diluted and excreted in urine. Therefore, increasing adhesion of mucosal layer may prolong retention time increase pharmacological activity. It is well known chitosan (Cs) a strong layer. Thus, established novel for-mulation enhance its antitumor activity by extending time. In research, we prepared Cs...