A5104273282- Genetic and phenotypic traits in livestock
- Genetic diversity and population structure
- Cancer-related molecular mechanisms research
- Ruminant Nutrition and Digestive Physiology
- Reproductive Physiology in Livestock
- Chromosomal and Genetic Variations
- Reproductive Biology and Fertility
- Genetic Mapping and Diversity in Plants and Animals
- Adipose Tissue and Metabolism
- Sperm and Testicular Function
- Animal Genetics and Reproduction
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- T-cell and B-cell Immunology
- Exercise and Physiological Responses
- Effects of Environmental Stressors on Livestock
- IL-33, ST2, and ILC Pathways
- Reproductive System and Pregnancy
- Molecular Biology Techniques and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Liver Disease Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- Peroxisome Proliferator-Activated Receptors
- Hypothalamic control of reproductive hormones
- Renal and related cancers
Ministry of Agriculture and Rural Affairs
2024-2025
Southwest University of Science and Technology
2024-2025
Huazhong Agricultural University
2024-2025
Research Institute of Animal Husbandry
2025
Tibet Academy of Agricultural and Animal Husbandry Sciences
2014-2024
Animal Science Research Institute
2023
Sichuan Agricultural University
2019-2023
Xinjiang Academy of Agricultural and Reclamation Science
2012
Shihezi University
2012
Abstract Comparative population genomics analysis is an effective approach to identify selection signatures in farm animals. In this study, we systematically investigated the six phenotypically diverse goat breeds using SNPs obtained from pooled whole-genome resequencing data. More than 95.5% of 446–642 million clean reads were mapped latest reference genome, which generated a sequencing depth ranging 22.30 31.75-fold for each breed. A total 5,802,307, 6,794,020, 7,562,312, 5,325,119,...
Abstract The interactions between the rumen microbiota and host are crucial for digestive absorptive processes of ruminants, they heavily influenced by climatic conditions their habitat. Owing to harsh high-altitude habitat, little is known about how ruminants regulate transcriptome composition microbiota. Using model species goats, we examined variations in microbiota, regulation, climate environment high altitude (Lhasa, Xizang; 3650 m) low (Chengdu, Sichuan, China; 500 goats. results 16 S...
As one of the important livestock species around world, goats provide abundant meat, milk, and fiber to fulfill basic human needs. However, genetic loci that underlie phenotypic variations in domestic are largely unknown, particularly for economically traits. In this study, we sequenced whole genome 38 from three Chinese breeds (Chengdu Brown, Jintang Black, Tibetan Cashmere) downloaded sequence data 30 five other (four non-Chinese breed) 21 Bezoar ibexes investigate composition selection...
The motility of sperm decreases following cryopreservation, which is closely associated with mitochondrial function. However, the alterations in metabolism after freezing goats remain unclear. This experiment aimed to investigate impact ultra-low temperature on goat sperm's energy and its potential correlation motility. results revealed that exhibited vacuolization, reduced matrix density, significantly decreased levels high-membrane mitochondria adenosine triphosphate content, accompanied...
Rumen flatulence is a diet-related rumen disease in ruminants. This study induced model Xizang sheep using alfalfa (HRF) and wheatgrass (MRF). The aim was to understand the microbiota diversity healthy pathological states, host-microbiota interactions, molecular mechanisms of flatulence. Results showed that pH HRF MRF groups lower than natural grass group (LRF). SCFA concentrations varied between groups: HRF, 2-BA CA increased; MRF, 4-MVA 5-MCA rose. Microbial analysis indicated alpha-...
ABSTRACT The interaction between microbiota and muscle by the rumen-muscle axis its impact on sheep meat flavor has received little attention. This study selected Xizang under summer autumn grazing conditions as models for different rumen bacteria intramuscular fat (IMF) to attempt address current research gap. Specifically, deposition characteristics of IMF expression lipid metabolism genes in were determined; 16S rDNA sequencing technology gas chromatography used metabolic products,...
Ensiling whole-crop oat (Avena sativa L.) has attracted a growing interest in the Qinghai-Tibet Plateau. The study aimed to investigate microbial community and chemical composition of fresh ensiling harvested from six different elevations Plateau.The (A. L. cv. Qingyin No. 1) was planted sites across Plateau (BM, Bomi County; BY, Bayi DZ, Dazi BR, Biru SC, Suo SN, Seni County), where were range 2,800-4,500 m above sea level (a. s. l.). Oat at milk stage ensiled for 90 days.The highest crude...
The Tibetan cashmere goat is a prolific breed in China. In sheep breeds, natural mutations have demonstrated that the transforming growth factor beta (TGF-β) super family ligands, such as differentiation 9 (GDF9), bone morphogenetic protein 15 (BMP15) and their type I receptor (bone (BMPR1B), are essential for ovulation increasing litter size. this study, 216 female goats were sampled, candidate genes with fecundity traits detected via restriction fragment length polymorphism (RFLP)...
Previous studies have presented evidence suggesting that altitude exerts detrimental effects on reproductive processes, yet the underlying mechanism remains elusive. Our study employed two distinct goat breeds inhabiting low and high altitudes, conducted a comparative analysis of mRNA profiles in testis tissues composition gut microbiota. The results revealed reduced size high-altitude goats. RNA-seq identified presence 214 differentially expressed genes (DEGs) testis. These DEGs resulted...
Brown adipose tissues have unique non-shivering thermogenesis functions, can be found in newborn ruminate animals, and then are gradually replaced by white adulthood. For the purpose of exploring intrinsic mechanism underlying conversion process from brown (BAT) to tissue (WAT), it is necessary utilize Quantitative PCR (qPCR) study gene expression profiling. In this study, we identified reference genes that were consistently expressed during transformation goat BAT WAT using RNA-seq data....
China has abundant population of Tibetan goats, but available information regarding genetic structure and phylogenetic status remains limited. Here, 130 mitochondrial D-loop sequences individuals from 10 goat populations located in distinct plateau areas were analyzed. Eighty-six haplotypes defined, among which 97.7% group-specific haplotypes. Haplotype nucleotide diversity indices 0.990 ± 0.003 0.0145 0.0013, respectively. The pairwise Wright's F-statistics ranged -0.028 to 0.385, over half...
It is commonly accepted that adiponectin binds to its two receptors regulate fatty acid metabolism in adipocytes. To better understand their functions the regulation of intramuscular adipogenesis goats, we cloned three genes (adiponectin [AdipoQ], receptor 1 [AdipoR1], and AdipoR2) encoding these proteins detected mRNA distribution different tissues. We also determined role AdipoQ adipogenic differentiation goat skeletal muscle satellite cells (SMSCs).SMSCs were isolated using mg/mL Pronase...
Abstract Background Copy number variations (CNVs) are a major form of genetic and involved in animal domestication adaptation to local environments. We investigated CNVs the domestic goat ( Capra hircus ) using Illumina short-read sequencing data, by comparing our lab data for 38 goats from three Chinese breeds (Chengdu Brown, Jintang Black, Tibetan Cashmere) public 26 individuals other (two Moroccan one Chinese) 21samples Bezoar ibexes. Results obtained total 2394 CNV regions (CNVRs)...
The Sichuan-Yunnan region is the main production area of yaks in southwestern China, with rich genetic resources Yaks. Nevertheless, there have been limited study on characteristics entire yak populations Tibet and China. In this study, we performed whole-genome resequencing to identify variation information a total 198 individuals from six breeds (populations) Sichuan (Muli yak, Jinchuan Changtai Maiwa yak), Yunnan (Zhongdian (Tibetan yak). aim was investigate diversity, population...