A5020534447- Metabolism, Diabetes, and Cancer
- Peroxisome Proliferator-Activated Receptors
- Hippo pathway signaling and YAP/TAZ
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Adipose Tissue and Metabolism
- Cell death mechanisms and regulation
Second Hospital of Shandong University
2024
Shanghai East Hospital
2023
The Hippo pathway is generally understood to inhibit tumor growth by phosphorylating the transcriptional cofactor YAP sequester it cytoplasm and reduce formation of YAP-TEAD complexes. Aberrant activation occurs in various cancers. However, we found a tumor-suppressive function clear cell renal carcinoma (ccRCC). Using cultures, xenografts, patient-derived explant models, that inhibition upstream Hippo-pathway kinases MST1 MST2 or expression constitutively active mutant impeded ccRCC...
The possible role of fatty acid translocase (CD36) in the treatment obesity has gained increasing research interest since researchers recognized its coordinated function uptake and oxidation. However, effect CD36 deficiency on intracellular insulin signaling is complex impact may depend different nutritional stresses. Therefore, we investigated various effects deletion C2C12 myotubes with or without palmitic (PA) overload. In present work, reported upregulated expression levels skeletal...
Obesity-related muscular dysfunction and relative muscle atrophy affect an increasing number of people. Elucidating the molecular mechanisms skeletal cell development growth may contribute to maintenance mass in obesity. Fatty acid translocase (FAT/CD36), as a long-chain fatty transport protein, is crucial for lipid metabolism signaling. CD36 known function myogenic differentiation, whether it affects proliferation cells underlying remain unclear. In this study, effect deficiency on...