A5103232273- Genetics and Neurodevelopmental Disorders
- Pancreatic function and diabetes
- Functional Brain Connectivity Studies
- CRISPR and Genetic Engineering
- Pluripotent Stem Cells Research
- Salmonella and Campylobacter epidemiology
- Vaccine Coverage and Hesitancy
- Endoplasmic Reticulum Stress and Disease
- Physical Activity and Health
- Animal Disease Management and Epidemiology
- Obesity, Physical Activity, Diet
- Ion Transport and Channel Regulation
- Neurobiology of Language and Bilingualism
- Dielectric properties of ceramics
- Methemoglobinemia and Tumor Lysis Syndrome
- Electronic and Structural Properties of Oxides
- Supramolecular Chemistry and Complexes
- RNA regulation and disease
- Photochromic and Fluorescence Chemistry
- Ginseng Biological Effects and Applications
- Sex work and related issues
- Supramolecular Self-Assembly in Materials
- Molecular Sensors and Ion Detection
- Machine Learning in Materials Science
- Autophagy in Disease and Therapy
South China Normal University
2024-2025
Shanghai East Hospital
2017-2025
First Affiliated Hospital of Dalian Medical University
2025
Hubei University of Medicine
2025
Dalian Medical University
2025
Taihe Hospital
2025
Huazhong University of Science and Technology
2012-2024
Tongji University
2018-2024
Anhui Agricultural University
2024
Affiliated Hospital of Youjiang Medical University for Nationalities
2024
The foodborne bacterial pathogen, <i>Campylobacter jejuni</i>, possesses an <i>N</i>-linked protein glycosylation (<i>pgl</i>) pathway involved in adding conserved heptasaccharides to asparagine-containing motifs of >60 proteins, and releasing the same glycan into its periplasm as free oligosaccharides. In this study, comparative genomics all 30 fully sequenced <i>Campylobacter</i> taxa revealed <i>pgl</i> gene clusters but one species. Structural, phylogenetic immunological studies showed...
Human embryonic stem cell-derived β cells (SC-β cells) hold great promise for treatment of diabetes, yet how to achieve functional maturation and protect them against metabolic stresses such as glucotoxicity lipotoxicity remains elusive. Our single-cell RNA-seq analysis reveals that ZnT8 loss function (LOF) accelerates the SC-β cells. As a result, LOF improves glucose-stimulated insulin secretion (GSIS) by releasing negative feedback zinc inhibition on secretion. Furthermore, we demonstrate...
Abstract Dysregulated neurite outgrowth and synapse formation underlie many psychiatric disorders, which are also manifested by wolfram syndrome (WS). Whether how the causative gene WFS1 deficiency affects remain elusive. By mirroring human brain development with cerebral organoids, -deficient organoids not only recapitulate neuronal loss in WS patients, but exhibit significantly impaired function associated reduced astrocytes. neurons autonomously delays differentiation altered expressions...
Due to the combination of flexibility and mobility, polycatenanes have potential in constructing various functional materials. To date, most previous works reported poly[2]catenanes with a degree polymerization (DP) around 20. However, it remains significant challenge synthesize higher DP value. Hydroxyl–yne click polymerization, bearing merits obtaining polymers high values, short reaction time, mild condition, is promising be employed preparing values. Herein, strategy using hydroxyl–yne...
Data driven material research is a hot topic in the cross field of artificial intelligence and materials science. The core new prediction to find relationship between structure properties. In this research, machine learning will have important advantages play an role for data. paper,we put forward framework combining feature engineering linear regression correlation properties from High temperature superconductor double perovskites solar cells were employed test feasibility method. former,...
Abstract Pancreatic β-cell failure by WFS1 deficiency is manifested in individuals with wolfram syndrome (WS). The lack of a suitable human model WS has impeded progress the development new treatments. Here, pluripotent stem cell derived pancreatic islets (SC-islets) harboring and mouse β specific Wfs1 knockout were applied to WS. We charted high-resolution roadmap single-cell RNA-seq (scRNA-seq) investigate pathogenesis for failure, revealing two distinct cellular fates along pseudotime...
Abstract Pancreatic β cell loss by cellular stress contributes to diabetes pathogenesis. Nevertheless, the fundamental mechanism of regulation remains elusive. Here, it is found that elevated zinc transportation causes excessive in pancreatic cells diabetes. With gene‐edited human embryonic stem cell‐derived (SC‐β cells) and primary islets, results reveal initiates integrated response (ISR), ultimately leads death. By contrary, genetic abolishment shields from exacerbated endoplasmic...
Electrostatic capacitors, though presenting faster rate capability and higher power density, are hindered in applications because of their low energy density. Accordingly, many efforts electrostatic for electronics electrical systems, have mainly concentrated on the development dielectric materials with high-energy density (Ud) charge-discharge efficiency (η) as well good stability performances thermal fatigue endurance. Herein, we demonstrate that an excellent Ud (∼90 J/cm3) high η...
In the brain, serotonergic neurons located in raphe nucleus are unique resource of neurotransmitter serotonin, which plays a pivotal role regulation brain development and functions. Dysfunction serotonin system is present many psychiatric disorders. Lack vitro functional human model limits understanding central its related diseases clinical applications. Previously, we have developed method generating from induced pluripotent stem cells (iPSCs). this study, analyzed features these...
Research has indicated that stress on the endoplasmic reticulum (ER) of a cell affects pathogenesis metabolic disorders such as obesity, type 2 diabetes mellitus, and non-alcoholic fatty liver disease (NAFLD). Palmitate, saturated acid, is known to induce toxicity death in various types cells. Tanshinone IIA (Tan IIA), one effective components traditional Chinese medicine Danshen, was reported exhibit variety biochemical activities, including amelioration ER stress-mediated apoptosis renal...
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is one of the most common X-linked enzymopathies caused by G6PD gene variant. The aim this study was to investigate molecular epidemiological characteristic among newborn screening population in Wuhan region. A total 430,806 healthy neonates area China were screened for from November 2016 December 2021. positive samples further detected with analysis. Among 957 abnormal enzyme activity, prevalence calculated as 0.22%. 38 genotypes found and...
Background: The comparison of clinical outcomes arthroscopic footprint-preserving knotless single-row repair with the tear completion technique for articular-sided partial-thickness rotator cuff tears (PTRCTs) remains unclear. Methods: A total 68 patients diagnosed PTRCTs who underwent between December 2014 and June 2015 were included. Of patients, 30 received (group 1) 38 2). Preoperative postoperative assessments compared. Results: Both groups had significantly improved American Shoulder...
Previous studies have shown that the visual word form area (VWFA) has structural and intrinsic functional connectivity with both language attention networks. Nevertheless, it is still unclear how pattern of VWFA regulated by processing demands induced experimental tasks, whether differentially regulate posterior (VWFA-1) anterior (VWFA-2) subregions VWFA. To address these questions, present study adopted two tasks varying in (i.e., verbal non-verbal tasks), used generalized...
Introduction: Less is known about the effects of different domains sedentary behaviors on healthy weight in young children. This cross-sectional study examined association between screen time (SST), non-screen-based (NSST), and overweight (and obesity) Chinese preschoolers. Methods: Data were collected from Physical Activity Health Tianjin Children (PATH-CC), involving children 3-6 years old their families. Children's status was classified according to international (IOTF) childhood BMI...
Cardiolipin (CL) is an anionic tetraacylphospholipid found in mammalian tissues, inner membrane of mitochondria and the cytoplasmic Gram-positive -negative bacteria. Lipid A principal structural component responsible for range biological activities lipopolysaccharides. Here we report a MALDI-MS-based method sensitive simultaneous analysis CL lipid from Helicobacter pylori cells. The sensitivity was demonstrated by single bacterial colony vitro grown H. strain NCTC 11637 (ATCC 43504). We then...
Abstract Objective Understanding HPV vaccination willingness and its influencing factors among female sex workers (FSWs) in entertainment venues an urban area of Guangxi, China. Methods From 15 August to October 2022, FSWs with commercial trade Guangxi were selected as the study subjects for questionnaire survey using method intentional sampling. The based on information-motivation-behavior (IMB) skills model was used collect basic characteristics, vaccine-related information cognition,...
Abstract Obesity, a growing global health concern, is closely linked to depression. However, the neural mechanism of association between obesity and depression remains poorly understood. In this study, neural‐specific WFS1 deficiency exacerbates vicious cycle in mice fed high‐fat diet (HFD), positioning as crucial factor cycle. Through human pluripotent stem cells (hESCs) differentiation, it demonstrated that regulates Zn 2+ homeostasis apoptosis progenitor (NPCs) cerebral organoids by...
Abstract The previously reported hydrogel assemblies carry bulky shapes, for which the unitary assembly form immensely restricted further applications. Yet there are abundant natural examples of network‐shaped constructed by animals, it is brought up inspirations constructing assemblies. Herein, with diverse functions reported. precursor solutions prepared acrylamide, 4‐acryloylmorpholine, choline chloride, and photo‐initiators. By means three dimension (3D) printing, networks formed driven...