A5100352156- Dermatology and Skin Diseases
- Corneal Surgery and Treatments
- Corneal surgery and disorders
- Asthma and respiratory diseases
- Olfactory and Sensory Function Studies
- Urticaria and Related Conditions
- Tryptophan and brain disorders
- Cannabis and Cannabinoid Research
- RNA and protein synthesis mechanisms
- Nausea and vomiting management
- Microwave Imaging and Scattering Analysis
- Exercise and Physiological Responses
- Acute Myocardial Infarction Research
- Telomeres, Telomerase, and Senescence
- Infant Health and Development
- Connexins and lens biology
- Cardiac Arrhythmias and Treatments
- Chemical synthesis and alkaloids
- Retinopathy of Prematurity Studies
- Stress Responses and Cortisol
- Sphingolipid Metabolism and Signaling
- Ion Transport and Channel Regulation
- Autoimmune Bullous Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Coronary Artery Anomalies
Second Affiliated Hospital of Xi'an Jiaotong University
2022-2025
Huazhong University of Science and Technology
2007-2024
Union Hospital
2016-2024
Doctors Hospital
2024
Shanghai University of Traditional Chinese Medicine
2023
Yueyang Hospital
2023
Tongji Hospital
2007-2022
Essential Research (United States)
2022
Weatherford College
2022
Wuhan Children's Hospital
2021-2022
Introduction Psoriasis is a common inflammatory skin disease recognized by the World Health Organization as "an incurable chronic, noninfectious, painful, disfiguring and disabling disease." The fact that metabolic syndrome (MetS) most important comorbidities of psoriasis suggests an role lipid metabolism in pathogenesis psoriasis. Narciclasine (Ncs) alkaloid isolated from Amaryllidaceae plants. Its biological activities include antitumor, antibacterial, antiinflammatory, anti-angiogenic...
Abstract Background Patients with ulcerative colitis (UC) exhibit abnormal amino acid (AA) metabolism. Taste receptors play a crucial role in the detection of intestinal AAs. Nevertheless, it remains unclear whether UC patients expression these colon. Methods An observational, multicenter study was conducted involving adult active and healthy controls (HCs), recruited from July 2023 to March 2024. Fresh feces rectosigmoid mucosal tissues were obtained each participant. The concentrations...
Psoriasis is a chronic hyperproliferative skin disease characterised by excessive growth of keratinocytes. Indeed, inducing keratinocyte apoptosis key mechanism responsible for psoriatic plaques clearance following some important existing therapies, which display pro-oxidant activity. Cold atmospheric plasma (CAP), acting as tuneable source reactive oxygen and nitrogen species (RONS), can controllably transfer RONS to the cellular environment, deliver antiproliferative concentrations exert...
Purpose: To explore the role of substrate stiffness and mechanism beneath corneal endothelial cells' (CECs') stemness maintenance differentiation. Methods: CECs were divided into central zone (8 mm trephined boundary) peripheral edge with attached limbal). Two zones analyzed by hematoxylin-eosin staining scanning electron microscopy for anatomic structure. The elastic modulus Descemet's membrane (DM) was atomic force microscopy. Compressed type I collagen gels different constructed as an in...
Background: Psoriasis is characterized by keratinocyte proliferation and massive inflammatory leukocytes infiltration, affecting 0.14%-1.99% of the world's population. Our aim was to identify novel potential therapeutic strategies for psoriasis. Methods: Weighted gene co-expression network analysis (WGCNA) performed modules that were closely related psoriasis based on GSE30999 dataset, which contained expression data from 85 patients with moderate-to-severe Then, angiopoietin-like 4...
ABSTRACT Dystrophic epidermolysis bullosa pruriginosa (DEB-Pr) is a rare subtype of dystrophic bullosa, and traditional treatments have limited efficacy. Dupilumab has demonstrated remarkable efficacy in relieving pruritus. In this case study, after treatment failed, providers recommended the patient begin dupilumab to treat his The was administrated loading dose 600 mg 300 every 2 weeks. Dermatology Life Quality Index Pruritic Numeric Rating Scale were used assess patient’s situation. After...
Background: Cannabinoid receptor 2 (CB2R) is a potential target for anti-inflammatory and pain therapeutics given its significant immunomodulatory analgesic effects. However, the role of CB2R in imiquimod (IMQ)-induced psoriasiform dermatitis (PsD) itch poorly understood. Objective: To investigate function mechanism PsD mice. Methods: Following daily treatment with topical IMQ cream 5-7 consecutive days C56BL/6 wild-type (WT) gene knockout (KO) mice, we assessed Psoriasis Area Severity Index...
Although researchers have shown that prodromal symptoms can predict acute coronary events, the ability of patients with syndrome (ACS) to identify these in a timely manner is limited.We aimed assess Chinese ACS and their responses by sex.This cross-sectional, multicenter study involved 5 teaching hospitals China included 806 admitted for between June 2013 February 2014. The McSweeney Acute Prodromal Myocardial Infarction Symptom Survey (Chinese version) was used gather data.Among (including...
Human corneal endothelial cells (HCECs) have limited proliferative capacity due to "contact-inhibition" at G1 phase. Such contact-inhibition can be delayed from Day 21 42 by switching EGF-containing SHEM LIF/bFGF-containing MESCM through transient activation of LIF-JAK1-STAT3 signaling that delays eventual nuclear translocation p16INK4a. Using the latter system, we reported a novel tissue engineering technique implementing 5 weekly knockdowns with p120 catenin (p120) and Kaiso siRNAs since 7...
Rat limbal niche cells (LNCs) have been proven to induce transdifferentiation of oral mucosal epithelial (OMECs) into corneal epithelial-like termed transdifferentiated (T-OMECs). This investigation aimed evaluate the effect subconjunctival T-OMEC injections on alkali-induced stem cell deficiency (LSCD) in rats. LNCs were cocultured with OMECs Transwell system obtain T-OMECs, NIH-3T3 serving as a control. Subconjunctival injection single or OMEC suspension was performed immediately after...
Cardiolipin (CL) is an anionic tetraacylphospholipid found in mammalian tissues, inner membrane of mitochondria and the cytoplasmic Gram-positive -negative bacteria. Lipid A principal structural component responsible for range biological activities lipopolysaccharides. Here we report a MALDI-MS-based method sensitive simultaneous analysis CL lipid from Helicobacter pylori cells. The sensitivity was demonstrated by single bacterial colony vitro grown H. strain NCTC 11637 (ATCC 43504). We then...
Abstract Background Lung ultrasound (LUS) and lung score (LUSS) have been successfully used to diagnose neonatal pneumonia, assess the lesion distribution, quantify aeration loss. The present study design determines diagnostic value of LUSS in semi‐quantitative assessment pneumonia coronavirus disease 2019 (COVID‐19) neonates. Methods Eleven COVID‐19 neonates born mothers with infection 11 age‐ gender‐matched controls were retrospectively studied. was acquired by assessing lesions loss 12...
Abstract Background Myocardial bridge (MB) often an inoffensive condition that goes in one or more of the coronary arteries through heart muscle instead lying on its surface. MBs sometimes leads to myocardial ischemic symptoms such as chest pain, even occurrence infarction. However, reports severe and recurrent cardiac adverse events related are rare. Case presentation A 44-year-old male patient who suffered from a four-hour crushing pain ten years ago, was diagnosed acute anterior...
Chronic itch severely reduces the quality of life patients. Electroacupuncture (EA) is widely used to treat chronic itch. However, underlying mechanism this therapeutic action EA largely unknown. Cannabinoid CB1 receptors in ventrolateral periaqueductal gray (vlPAG) mediate analgesic effect EA. Using a dry skin-induced model mice, we determined whether treatment via vlPAG. We showed that optimal inhibitory on was achieved at high frequency and intensity (100 Hz 3 mA) "Quchi" (LI11) "Hegu"...
This paper reports the diagnosis and treatment process of a case fetal mesenchymal hamartoma liver (MHL), reviews previous literature reports. At 38+2 weeks gestation, prenatal ultrasound found well bound mixed solid cystic mass, which was located at lower edge right lobe in front kidney fetus, but source nature mass were not clear by ultrasound. Due to approaching due date, fetus showed no other abnormal symptoms, special given with consent family members. A female delivered weighing 3,520...
Prurigo nodularis (PN) is a chronic inflammatory skin disease characterized by severe itching accompanied multiple nodules throughout the body. There currently no effective drug‐targeted treatment for PN. Dupilumab fully human monoclonal antibody which can suppress Th2 reaction. We aimed to assess efficacy and safety of dupilumab in were 29 PN patients who received four months. Serum total immunoglobulin E (Ig E), eosinophil counts, dermatology life quality index (DLQI), numeric rating scale...
There are no evidence-based data to confirm the efficacy of aromatic essential oil nursing in patients after laparoscopic cholecystectomy (LC). Therefore, order provide new medical evidence for clinical treatment, we undertook this protocol systematic review and meta-analysis assess effectiveness safety on mental state undergoing LC.The retrieval strategy will be developed by medicine librarians US Library Medicine database, Cochrane Database Systematic Reviews, Excerpta Medica database. The...
Purpose: The aim of this study was to characterize key biomarkers associated with pyroptosis in atopic dermatitis (AD). Materials and methods: To identify the differentially expressed pyroptosis-related genes (DEPRGs), gene expression profiles GSE16161 GSE32924 from Gene Expression Omnibus (GEO) database were utilized. Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses conducted determine potential biological functions involved pathways. Furthermore,...
Objective To assess the psychosomatic health status of patients with facial steroiddependent dermatitis by using Pittsburgh sleep quality index (PSQI),self-rating anxiety scale (SAS) and selfrating depression (SDS).Methods Psychosomatic was evaluated PSQI,SDS SAS in 92 steroid-dependent 50 healthy controls.Results The scores on were higher than those controls (63.11 ± 10.29 vs.36.78 2.46,53.24 9.98 vs.31.29 9.45,both P ＜ 0.01).There significant differences between two groups sleep.The...