A5077147485- Plasma Applications and Diagnostics
- Advancements in Transdermal Drug Delivery
- Tattoo and Body Piercing Complications
- Dust and Plasma Wave Phenomena
- Dermatologic Treatments and Research
- Microencapsulation and Drying Processes
- Plasma Diagnostics and Applications
- Surface Modification and Superhydrophobicity
- Protein purification and stability
- Heme Oxygenase-1 and Carbon Monoxide
- Microbial Inactivation Methods
- Aerosol Filtration and Electrostatic Precipitation
- Hemoglobin structure and function
- Mass Spectrometry Techniques and Applications
- Proteins in Food Systems
- Surfactants and Colloidal Systems
- Antifungal resistance and susceptibility
- Electrohydrodynamics and Fluid Dynamics
- Combustion and Detonation Processes
- 3D Printing in Biomedical Research
- Medical and Biological Ozone Research
- Nanomaterials and Printing Technologies
- Burn Injury Management and Outcomes
- Dendrimers and Hyperbranched Polymers
- Pickering emulsions and particle stabilization
Ji Hua Laboratory
2020-2021
Huazhong University of Science and Technology
2015-2020
Shanghai Jiao Tong University
2020
University of Antwerp
2020
John Wiley & Sons (Germany)
2020
State Key Laboratory of Advanced Electromagnetic Engineering and Technology
2017
In this work, an actual biological tissue is used to investigate how thick the reactive oxygen and nitrogen species (RONS) produced by a plasma jet can penetrate through tissue. This one of most critical questions in medicine. The concentration RONS (O3, H2O2, OH, NO2−, NO2− + NO3−) penetrating different thickness measured. It found that (ROS) are significantly consumed For 500 μm, there only about five percent or even less ROS OH) On other hand, more than 80% (NO2− able μm Furthermore,...
In this work, a co-culture system with liver cancer cell line HepG2 and normal L02 is used to investigate the selective effect on cells by plasma activated medium (PAM), which closer real environment where develop. Besides, better model study than widely separate culture systems, are cultured independently. By using system, it found that there an optimum dose of PAM induce significant apoptosis while keeping minimum damage cells.
In this work, reactive oxygen and nitrogen species (RONS) generated by a plasma jet penetrating through left in the skin after treatment are measured, effects of stratum corneum (SC) on penetration RONS also investigated. It is found that can penetrate skin, some kinds could be enhanced significantly tape stripping SC layer skin. Further investigations find typical species, including OH, 1O2, O3, H2O2, cannot mice at all (under detection limit) no matter whether present or not, where...
Psoriasis is a chronic hyperproliferative skin disease characterised by excessive growth of keratinocytes. Indeed, inducing keratinocyte apoptosis key mechanism responsible for psoriatic plaques clearance following some important existing therapies, which display pro-oxidant activity. Cold atmospheric plasma (CAP), acting as tuneable source reactive oxygen and nitrogen species (RONS), can controllably transfer RONS to the cellular environment, deliver antiproliferative concentrations exert...
Two of the key questions in plasma medicine are how deep reactive oxygen and nitrogen species (RONS) generated by a can penetrate into tissue liquid (extracellular intracellular fluid) composition affects concentration RONS. In this paper, different thicknesses pig muscle used as mode to investigate effect thickness on penetration RONS through tissue. Six types (inorganic group: double-distilled water (DDW), 1% phosphate-buffered saline, 0.9% NaCl; organic 5% glucose, 2% serum 10% solution)...
Abstract Fungal infections induced by Candida albicans have increased worldwide due to emerging resistance antifungal agents, which is largely caused biofilm formation. Thus, a new and effective antimicrobial strategy urgently required in treatment of C. biofilm‐associated infections. In this study, the inactivation effects cold plasma for are assessed vitro vivo. studies indicate that suspension inactivated significantly treatment. vivo achieves best effect with an optimal dose (4 min...
Abstract The penetration of reactive oxygen and nitrogen species (RONS) across the stratum corneum (SC) is a necessary crucial process in many skin‐related plasma medical applications. To gain more insights into this behavior, we combined experimental measurements permeability dry moist SC layers with computer simulations model lipid membranes. We measured permeation relatively stable molecules, which are typically generated by plasma, namely H 2 O , NO 3 − . Furthermore, calculated free...
The present research reported the effects of structural properties and immunoreactivity celiac-toxic peptides wheat storage proteins modified by cold jet atmospheric pressure (CJAP) plasma. It could generate numerous high-energy excited atoms, photons, electrons, reactive oxygen nitrogen species, including O3, H2O2, •OH, NO2- NO3- etc., to modify two model proteins. Orbitrap HR-LC-MS/MS was utilized identify quantify CJAP plasma-modified peptide products. Backbone cleavage QQPFP PQPQLPY at...
Abstract Transdermal drug delivery (TDD) is an important method, and cold atmospheric plasma has been proven its potential as a TDD approach. In this study, 9‐channel jet array was designed to enhance efficiency. The Franz diffusion experiment showed that the efficiency of across skin enhanced about 2–110 times after treatment. histological analysis structure stratum corneum could be destroyed by plasma. Further investigations indicated reactive oxygen species play key role in enhancing Our...
In clinical plasma medicine, the long-term safety is an important issue which needs to be addressed. this study, normal human liver cell line L02 was chosen as in vitro model investigate genotoxic and mutagenic properties of atmospheric pressure jet. The treated by first for different times, then, survived progeny cells from 30 min treatment time after seven passages (approximately 20 generations) were again. Apoptosis assay, micronucleus formation hypoxanthine phosphoribosyl transferase...
To better understand the role of residual charges in repeatability an atmospheric-pressure He plasma plume, effects N <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> /O additives on minimum pulse repetition frequency f xmlns:xlink="http://www.w3.org/1999/xlink">min</sub> to sustain repeatable discharge are investigated for first time. First, when percentage gas He/N mixture increases from 0% 1.7%, 130 900 Hz. While O He/O 0.38% keeps...
Outside Front Cover: The penetration of reactive oxygen and nitrogen species (RONS) across the stratum corneum (SC) is a crucial process in skin-related plasma medical applications. To gain more insight this process, experiments molecular dynamics (MD) simulations were carried out. results show different permeabilities kinds RONS, which may help to understand underlying mechanisms interaction with bio-material. Further details can be found article by Jiangwei Duan, Mingyu Ma, Maksudbek...
Several research on the interaction between cold atmospheric plasma (CAP) and skin have shown that great potential of CAP used in transdermal drug delivery (TDD). In this study, a jet array device was to enhance TDD efficiency [1]. Total discharge current measured, peak value is about 1A duration time 100ns. Full thickness Porcine ear exposed during treatment, treatment 3 min 6 min. Paten blue as model study using Franz diffusion cell system[2]. Skin surface temperature also measured by an...
Outside Front Cover: A touchable plasma jet array was designed for enhancing transdermal drug delivery. The picture on the right shows results of in vitro delivery test with or without treatment. treatment skin has an effect hydrophilic macromolecular drug, patent blue V (1159.427 Da), With mixing 0.5% oxygen working gas, further improved. Further details can be found article by Yang Lv, Lanlan Nie, Jiangwei Duan, Zhiyu Li, and Xinpei Lu (e2000180).