A5100622128- Electrospun Nanofibers in Biomedical Applications
- Food composition and properties
- Nanoplatforms for cancer theranostics
- Phytase and its Applications
- Extracellular vesicles in disease
- Ginseng Biological Effects and Applications
- Nanoparticle-Based Drug Delivery
- Wheat and Barley Genetics and Pathology
- Analytical chemistry methods development
- Plant-based Medicinal Research
- 3D Printing in Biomedical Research
- Advanced MEMS and NEMS Technologies
- Bee Products Chemical Analysis
- Immunotherapy and Immune Responses
- Surface Modification and Superhydrophobicity
- Proteins in Food Systems
- Ophthalmology and Visual Impairment Studies
- Mechanical and Optical Resonators
- Force Microscopy Techniques and Applications
- Tissue Engineering and Regenerative Medicine
- Additive Manufacturing and 3D Printing Technologies
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Surgical Sutures and Adhesives
- Biomedical Research and Pathophysiology
Huazhong University of Science and Technology
2013-2024
Beihang University
2019-2024
Guangzhou University of Chinese Medicine
2024
Affiliated Hospital of Hebei University
2024
Chongqing Medical University
2024
Second Affiliated Hospital of Zhejiang University
2024
Lanzhou University
2024
Zhongshan Hospital
2016-2023
Shanghai Medical Information Center
2023
Shanghai Institute of Hematology
2023
Abstract Current antigen‐encapsulated multifunctional nanovaccines for oncotherapy suffer from limited antigen loading efficiency, low yield, tedious manufacture, and systemic toxicity. Here, an antigen‐directed strategy the fabrication of nanovaccine with ultrahigh efficiency in a facile way tumor photothermal‐immunotherapy is shown. As proof concept, model ovalbumin (OVA) used as natural carrier to load representative theranostic agent indocyanine green (ICG). Mixing OVA ICG aqueous...
Abstract Background This study was designed to assess the associations between emerging cardiometabolic indices—the atherogenic index of plasma (AIP), stress hyperglycemia ratio (SHR), triglyceride-glucose (TyG) index, and homeostasis model assessment insulin resistance (HOMA-IR)—and incidence diabetic kidney disease (DKD) in type 2 diabetes (T2D) patients. Methods We consecutively enrolled 4351 T2D The AIP, SHR, TyG HOMA-IR were calculated from baseline parameters. DKD defined as a urine...
Abstract Asthma is a chronic inflammatory disease characterized by airway hyperresponsiveness (AHR), inflammation, and remodeling. Epithelial-mesenchymal transition (EMT) an essential player in these alterations. Scutellarin isolated from Erigeron breviscapus . Its vascular relaxative, myocardial protective, anti-inflammatory effects have been well established. This study was designed to detect the biological roles of scutellarin asthma its related mechanisms. The asthma-like conditions were...
Significance The challenge in manufacturing stretchable and tough reconstituted tissues lies the limitation of current approaches to recapitulate exceptional mechanical properties native while maintaining cellular functions. Here, we simulate complexity by integrating electrospinning tissue engineering develop a highly living consisting bioinspired hierarchical helical scaffold seeded cells. well-organized construct has toughness 57 GJ m −3 can be stretched up 15 times its length sheltering...
Versatile bioinspired strategies are urgently needed to fabricate high-performance nanoprobes for biomedical application. Herein, a novel technology of mimicking drug–substrate interaction is reported the fabrication nanoprobes. As proof concept, multifunctional bovine serum albumin (BSA)-MnO2 nanoparticle-based nanoplatform strategically engineered via disinfection process KMnO4 in an extremely facile way. The prepared BSA-MnO2 nanoparticles possess sub-10 nm and uniform size, excellent...
This study delves into the immunoreactivity of lactic acid bacterium (LAB)–fermented soy protein isolates (FSPIs) with various structural features during gastrointestinal digestion and absorption. The behavior structural...
Abstract: A synergistic approach by the combination of magnetic nanoparticles with an alternating field for transdermal drug delivery was investigated. Methotrexate-loaded silk fibroin were prepared using suspension-enhanced dispersion supercritical CO 2 . The physiochemical properties characterized. In vitro studies on permeation across skin performed under different fields in comparison passive diffusion. flux enhancement factor found to increase a stationary field, while enhanced more...
Renal fibrosis is a significant threat to public health globally. Diverse primary aetiologies eventually result in chronic kidney disease (CKD) and immune cells influence this process. The roles of monocytes/macrophages, T cells, mast have been carefully examined, whilst only few studies focused on the effect B cells. We investigated B-cell function tubulointerstitial induced by unilateral ureteral obstruction (UUO), using genetic B-cell-deficient μMT mice or CD20 antibody-mediated...
Avenin-like b proteins are a small family of wheat storage proteins, each containing 18 or 19 cysteine residues. The role these with high numbers residues, in determining the functional properties flour is unclear. In present study, two transgenic lines bread overexpressing avenin-like gene were generated to investigate effects on dough mixing properties. Sodium dodecyl sulfate sedimentation (SDSS) test and Mixograph analysis demonstrated that overexpression both significantly increased SDSS...
Fe–polyphenols coordination polymers have emerged as a versatile theranostic nanoplatform for biological applications owing to the appealing biocompatibility of precursors from nature. Incorporating bioactive molecules with is greatly significant take full advantages their superiorities advanced application. Herein, we show functional-protein-assisted fabrication Fe–gallic acid (GA) nanonetworks via mild and facile biomineralization photothermal therapy. Mild alkaline condition crucial...
A highly specific and sensitive method using high performance liquid chromatography coupled with diode-array detection ion-trap mass spectrometry (HPLC-DAD-MSn) was developed for study of the constituents flavonoid extract jujube seeds metabolites in rat plasma, urine, feces samples after oral administration seeds. Two major flavonoids (spinosin 6′′′-feruloylspinosin) content >60% were detected confirmed by comparison reference standards. Furthermore, five metabolic components seven four...
The process of reconstructing an arterial graft is a complex and dynamic that subject to the influence various mechanical factors, including tissue regeneration blood pressure. attainment favorable remodeling outcomes contingent upon biocompatibility biomechanical properties graft. A promising strategy involves emulation three-layer structure native artery, wherein inner layer composed polycaprolactone (PCL) fibers aligned with flow, exhibiting excellent fosters endothelial cell growth...
Abstract Subunit pair 1Dx5 + 1Dy10 was recognized as superior subunit combination in wheat and contained an extra repetitive-domain cysteine residue that important for understanding the formation of dough viscoelasticity. In this research, one specific serine codon 1Ax1 gene corresponding to substituted by a through site-directed mutagenesis. Four homozygous transgenic lines (T 4 ) expressing mutant ( mut1Ax1 were produced. Their greater strength stability confirmed mixograph associated with...
A biocompatible and sensitive dual-targeting Fe<sub>3</sub>O<sub>4</sub>nanoprobe co-modified with biosafe hyaluronic acid transferrin was developed for tumor-targeted MR imaging.
The present research reported the effects of structural properties and immunoreactivity celiac-toxic peptides wheat storage proteins modified by cold jet atmospheric pressure (CJAP) plasma. It could generate numerous high-energy excited atoms, photons, electrons, reactive oxygen nitrogen species, including O3, H2O2, •OH, NO2- NO3- etc., to modify two model proteins. Orbitrap HR-LC-MS/MS was utilized identify quantify CJAP plasma-modified peptide products. Backbone cleavage QQPFP PQPQLPY at...