A5041932034- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Cardiac Fibrosis and Remodeling
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Advanced Glycation End Products research
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging Techniques and Applications
- Dialysis and Renal Disease Management
- Lipoproteins and Cardiovascular Health
- Medical Image Segmentation Techniques
- Antiplatelet Therapy and Cardiovascular Diseases
- Medical Imaging and Analysis
- Burn Injury Management and Outcomes
- Chronic Kidney Disease and Diabetes
- Atherosclerosis and Cardiovascular Diseases
- Radiomics and Machine Learning in Medical Imaging
- Renal and Vascular Pathologies
- Cardiac pacing and defibrillation studies
- Urinary Bladder and Prostate Research
Shanghai Jiao Tong University
2015-2025
Ruijin Hospital
2015-2025
Shanghai Stomatological Hospital
2024
Tongji University
2024
The University of Adelaide
2020-2022
Chinese Academy of Meteorological Sciences
2022
China Meteorological Administration
2022
Boehringer Ingelheim (United States)
2019
New York University
2015
Columbia University Irving Medical Center
2010-2013
The transplantation of mesenchymal stem cells (MSCs) is considered to be a promising treatment for ischemic heart disease; however, the therapeutic effects and underlying mechanisms action require further evaluation. Mitochondrial dysfunction key event in simulated ischemia/reperfusion (SI/R) injury. purpose present study was investigate mechanism mitochondrial transfer, which may involved antiapoptotic co-culture with MSCs. An vitro model used study. apoptotic indexes were significantly...
Cardiovascular disease is the leading cause of death in patients with chronic kidney disease. A body evidence suggests that p-cresyl sulfate (PCS), a uremic toxin, associated cardiovascular mortality rate disease; however, molecular mechanisms underlying this feature have not yet been fully elucidated.We aimed to determine whether PCS accumulation could adversely affect cardiac dysfunction via direct cytotoxicity cardiomyocytes. In mice underwent 5/6 nephrectomy, promoted apoptosis and...
Rationale: Macrophages are critically involved in wound healing following myocardial infarction (MI). Lgr4, a member of LGR (leucine-rich repeat-containing G protein-coupled receptor) family, is emerging as regulator macrophage-associated immune responses. However, the contribution Lgr4 to macrophage phenotype and function context MI remains unclear. Objective: To determine role dissect underlying mechanisms. Methods Results: During early inflammatory phase MI, infarct macrophages rather...
Background Advanced glycation end-products (AGEs) have been implicated in diverse pathological settings including diabetes, inflammation and acute ischemia/reperfusion injury the heart. AGEs interact with receptor for (RAGE) transduce signals through activation of MAPKs proapoptotic pathways. In current study, adult cardiomyocytes were studied an vitro (I/R) model to delineate molecular mechanisms underlying RAGE-mediated due hypoxia/reoxygenation (H/R). Methodology/Principal Findings...
To assess predictive value of 68Ga-labeled fibroblast activation protein inhibitor-04 ([68Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infarction (STEMI).Twenty-six STEMI were included the study. [68Ga]Ga-DOTA-FAPI-04 was performed at baseline and average 12 months after STEMI. LV defined as >10% increase end-systolic volume (LVESV) from to months.The group demonstrated higher uptake (UV) than non-LV (p < 0.001). UV a...
Myocardial ischemia/reperfusion (I/R) injury interferes with the restoration of blood flow to ischemic myocardium. Oxidative stress-elicited apoptosis has been reported contribute I/R injury. All-trans retinoic acid (ATRA) anti-apoptotic activity as previously reported. Here, we investigated effects and mechanism action ATRA on myocardial both in vivo vitro. In vivo, reduced size infarcted area (17.81±1.05% vs. 24.41±1.03%, P<0.05) rescued cardiac function loss (ejection fraction 46.42±6.76%...
Renal fibrosis is a significant threat to public health globally. Diverse primary aetiologies eventually result in chronic kidney disease (CKD) and immune cells influence this process. The roles of monocytes/macrophages, T cells, mast have been carefully examined, whilst only few studies focused on the effect B cells. We investigated B-cell function tubulointerstitial induced by unilateral ureteral obstruction (UUO), using genetic B-cell-deficient μMT mice or CD20 antibody-mediated...
Abstract This study evaluated the impact of platelet‐rich plasma (PRP) and fibrin (PRF) on burn wound with dual‐species biofilm. Pseudomonas aeruginosa ( P. ) Staphylococcus aureus S. were applied to infect in rats establish a biofilm model. After infection, was treated ionized silver (AG), PRF, PRP. Silver scanning electron microscopy (SEM) used assess adhesion after infection. PRF PRP reduced size from day 8 injuries, while AG significantly promoted healing at 12. New collagen formed...
The sequestration of nanoparticles by mononuclear phagocyte system is a challenge for the use nanotherapy treating cardiovascular diseases due to conventionally perceived loss therapeutic potency. Here, we revitalize unlocking an alternative route in which nanomedicines are redirected spleen, leveraging its potential as highly efficient and targeted site remote conditioning, or tele-conditioning myocardial reperfusion injury. theoretical foundation underpinning splenogenic nature recruited...
Abstract Although the drug-eluting stent (DES) has become standard for percutaneous coronary intervention (PCI)-based revascularization, concerns remain regarding use of DES, mainly due to its permanent rigid constraint vessels. A bioresorbable (BRS) was thus developed as an alternative which can be absorbed entirely after therapeutic period. Magnesium (Mg)-based BRSs have attracted a great deal attention their suitable mechanical properties, innovative chemical features, and well-proven...
Dietary n-3 fatty acids (FAs) may reduce cardiovascular disease risk. We questioned whether acute administration of rich triglyceride (TG) emulsions could preserve cardiac function and decrease injury after ischemia/reperfusion (I/R) insult. used two different experimental models: in vivo, C57BL/6 mice were exposed to occlusion the left anterior descending coronary artery (LAD), ex-vivo, murine hearts perfused using Langendorff technique (LT). In LAD model, treated with TG emulsion (1.5g/kg...
Earlier studies have demonstrated that aldose reductase (AR) plays a key role in mediating ischemia-reperfusion (I/R) injury. Our objective was to investigate if AR mediates I/R injury by influencing phosphorylation of glycogen synthase kinase-3β (p-GSK3β). To this issue, we used three separate models study the effects stress on heart. Hearts isolated from wild-type (WT), human expressing transgenic (ARTg), and knockout (ARKO) mice were perfused with/without GSK3β inhibitors (SB-216763 LiCl)...
The progression of NTLs after PCI accounts for a significant portion future adverse cardiac events. reduction in LDL-C reduces cardiovascular This has, however, not yet been shown real-world setting. We aimed to investigate the association between changes with NTLs. A total 847 patients successful were enrolled. Patients follow-up ≥ 1.4 mmol/L or percent <50% compared baseline Non-optimal group (n = 793); < and ≥50% Optimal 54). Compared group, presented lower rate NTL plaque (11.11% vs....
The B cell activating factor (BAFF) is a survival involved in atherosclerosis and ischemia-reperfusion (IR) injury. This study sought to investigate whether BAFF potential predictor of poor outcomes patients with ST-segment elevation myocardial infarction (STEMI).We prospectively enrolled 299 STEMI, serum levels were measured. All subjects followed for three years. primary endpoint was major adverse cardiovascular events (MACEs), including death, nonfatal reinfarction, hospitalization heart...
Abstract Background Chronic kidney disease (CKD) accelerates atherosclerosis, but the mechanisms remain unclear. Tyrosine sulfation has been recognized as a key post-translational modification (PTM) in regulation of various cellular processes, and sulfated adhesion molecules chemokine receptors have shown to participate pathogenesis atherosclerosis via enhancement monocyte/macrophage function. The levels inorganic sulfate, essential substrate for reaction, are dramatically increased patients...
Background: Mitsugumin 53 or Tripartite motif 72 (MG53/TRIM72), a myokine/cardiokine belonging to the tripartite family, can protect heart from ischemic injury and regulate lipid metabolism in rodents. However, its biological function humans remains unclear. This study sought investigate relationship between circulating MG53 levels coronary artery disease (CAD). Methods: The concentration of was measured by enzyme-linked immunosorbent assay (ELISA) serum samples 639 patients who underwent...
Background The cardioprotective effects of soluble receptor for advanced glycation end-products (sRAGE) have not been evaluated in large animals and the underlying mechanisms are fully understood. This study aimed to evaluate intra-coronary administration sRAGE on left ventricular function myocardial remodeling a porcine model ischemia-reperfusion (I/R) injury. Methods Ten male minipigs with I/R injury were randomly allocated receive (sRAGE group, n=5) or saline (control n=5)....
There is a growing recognition of the association between chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and erectile dysfunction (ED); however, most reports are based on questionnaires which cannot distinguish organic functional ED. The purpose this study was to determine exact relationship CP/CPPS ED, investigate changes in organ structure function rat model CP/CPPS. We established experimental autoimmune prostatitis (EAP), valid for Erectile EAP normal rats comparable after...
Obstructive sleep apnea (OSA) is associated with acute nocturnal hemodynamic and neurohormonal abnormalities that may increase the risk of coronary events, especially during nighttime. This study sought to investigate day-night pattern ST-segment elevation myocardial infarction (STEMI) onset in patients OSA its impact on cardiovascular adverse events.
BACKGROUND: Drug-eluting balloons (DEB) may be promising technology for treating atherosclerotic arterial disease.In fact, several DEBs have been clinically available the treatment of coronary in-stent restenosis (ISR), de novo lesions, and peripheral artery disease.OBJECTIVE: We sought to elucidate mechanism action in vivo safety efficacy a novel iopromide-based paclitaxel-eluting balloon.METHODS: In vitro cytotoxicity DEB on human umbilical vein endothelial cells (HUVECs) pharmacokinetics...
Investigating the prognostic value of Murray law-based quantitative flow ratio (μQFR) on clinical outcome after treatment in-stent restenosis (ISR) with a drug-coated balloon (DCB).Patients participating in previous randomized trial for DCB-ISR were post-hoc analyzed. The primary endpoint was vessel-oriented composite (VOCE), defined as cardiac death, target vessel-related myocardial infarction, and ischemia-driven vessel revascularization. μQFRs at baseline DCB angioplasty calculated, its...