Leilei Xia

ORCID: 0000-0003-2954-7256
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About
Contact & Profiles
Research Areas
  • Bladder and Urothelial Cancer Treatments
  • Urinary and Genital Oncology Studies
  • Renal cell carcinoma treatment
  • Prostate Cancer Diagnosis and Treatment
  • Urological Disorders and Treatments
  • Esophageal Cancer Research and Treatment
  • Health Systems, Economic Evaluations, Quality of Life
  • Lung Cancer Diagnosis and Treatment
  • Renal and related cancers
  • Pelvic floor disorders treatments
  • Cardiac, Anesthesia and Surgical Outcomes
  • Seismic Performance and Analysis
  • Prostate Cancer Treatment and Research
  • Meta-analysis and systematic reviews
  • Nanoplatforms for cancer theranostics
  • Structural Engineering and Vibration Analysis
  • Bone Tissue Engineering Materials
  • Testicular diseases and treatments
  • Multiple and Secondary Primary Cancers
  • Vibration Control and Rheological Fluids
  • Urologic and reproductive health conditions
  • Ureteral procedures and complications
  • Renal and Vascular Pathologies
  • Enhanced Recovery After Surgery
  • Frailty in Older Adults

USC Norris Comprehensive Cancer Center
2024-2025

University of Southern California
2024-2025

Keck Hospital of USC
2024

Irvine University
2021-2023

University of California, Irvine
2021-2023

Wuhan University of Technology
2013-2023

Vita-Salute San Raffaele University
2023

University of Pennsylvania Health System
2020-2023

University of Pennsylvania
2016-2022

Philadelphia University
2017-2020

Introduction Fluorescence-guided surgery has emerged as a powerful tool to detect, localize and resect tumors in the operative setting. Our laboratory pioneered novel way administer an FDA-approved near-infrared (NIR) contrast agent help surgeons with this task. This technique, coined Second Window ICG, exploits natural permeability of tumor vasculature its poor clearance deliver high doses indocyanine green (ICG) tumors. technique differs substantially from established ICG video angiography...

10.1371/journal.pone.0182034 article EN cc-by PLoS ONE 2017-07-24

Cervical cancer, one of the leading causes female deaths, remains a top cause mortality in gynecologic oncology and tends to affect younger individuals. However, pathogenesis cervical cancer is still far from clear. Given high incidence uncovering as well identifying novel biomarkers are great significance desperately needed.First, raw data were downloaded Gene Expression Omnibus database. The Robuse Multi-Array Average algorithm combat function sva package subsequently applied preprocess...

10.2147/cmar.s162813 article EN cc-by-nc Cancer Management and Research 2018-04-01

Objective: To determine if intraoperative molecular imaging (IMI) can improve detection of malignant pulmonary nodules. Background: 18-Fluorodeoxyglucose positron emission tomography (PET) is commonly utilized in preoperative assessment patients with solid malignancies; however, false negatives and positives remain major limitations. Using nodules as a study model, we hypothesized that IMI folate receptor targeted near-infrared contrast agent (OTL38) nodule identification when combined PET....

10.1097/sla.0000000000002382 article EN Annals of Surgery 2017-07-26

Copper nanoparticles (Cu-NPs) and other inorganic nanomaterials have caused increasing concern owing to be widely used.Early studies reported that they can result in injuries the kidney, liver spleen of mice; cause embryonic damage; inhibit reproductive capacity red worms.However, few toxicity Cu-NPs on systems mammals.In present work, we explored cytotoxicity human extravillous trophoblast cells organs mice.Cu-NPs induced ovarian placental pathophysiology dysfunction mice.These also...

10.7150/ijbs.27640 article EN cc-by-nc International Journal of Biological Sciences 2018-01-01

No AccessJournal of UrologyAdult Urology1 Nov 2019National Variation in Opioid Prescription Fills and Long-Term Use Naïve Patients after Urological SurgeryThis article is commented on by the following:Editorial CommentEditorial Comment Ian Berger, Marshall Strother, Ruchika Talwar, Justin Ziemba, Christopher Wirtalla, Leilei Xia, Thomas Guzzo, M. Kit Delgado, Rachel Kelz BergerIan Berger *Correspondence: Jordan Medical Education Center, 6th Floor, 3400 Civic Center Blvd., Building 421,...

10.1097/ju.0000000000000343 article EN The Journal of Urology 2019-05-21

750 Background: Despite current guidelines recommendations to administer adjuvant nivolumab following radical cystectomy (RC) in patients with adverse pathologies, regardless of prior neoadjuvant chemotherapy (NAC), evidence on the long-term efficacy ICIs remains sparse. This study aims evaluate potential survival benefits two most common ICIs, Nivolumab and Pembrolizumab, muscle-invasive bladder cancer (MIBC) at a single institution. Methods: We queried our IRB-approved, prospectively...

10.1200/jco.2025.43.5_suppl.750 article EN Journal of Clinical Oncology 2025-02-10

874 Background: Over 50% of patients diagnosed with muscle-invasive bladder cancer are estimated to experience urothelial cell carcinoma (UCC) recurrence following radical cystectomy (RC). Current studies have found clinicopathological factors associated overall UCC recurrence; however, there is a lack data on variations between early versus late recurrence. This study examines the differences these cohorts. Methods: Within our single institutional IRB-approved database, we reviewed 1,050...

10.1200/jco.2025.43.5_suppl.874 article EN Journal of Clinical Oncology 2025-02-10

742 Background: Transurethral resection of bladder tumor (TURBT) is a widely utilized procedure for the diagnosis and treatment cancer (BC). Despite its well-established role, TURBT associated with relatively high rate postprocedural complications. This study aimed to provide an update on most prevalent complications following TURBT, using data from American College Surgeons National Surgical Quality Improvement Program (ACS NSQIP) 2022 database. Methods: The ACS NSQIP database was queried...

10.1200/jco.2025.43.5_suppl.742 article EN Journal of Clinical Oncology 2025-02-10
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