A5015178970- Digital Radiography and Breast Imaging
- Medical Imaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Radiation Dose and Imaging
- Advanced Semiconductor Detectors and Materials
- AI in cancer detection
- Radiation Detection and Scintillator Technologies
- Cerebrovascular and Carotid Artery Diseases
- Radiomics and Machine Learning in Medical Imaging
- Breast Cancer Treatment Studies
- Intracranial Aneurysms: Treatment and Complications
- Optical Imaging and Spectroscopy Techniques
- Advanced X-ray Imaging Techniques
- Infrared Thermography in Medicine
- MRI in cancer diagnosis
- Global Cancer Incidence and Screening
- Advanced Data Compression Techniques
- Advanced Radiotherapy Techniques
- Advanced MRI Techniques and Applications
- Breast Lesions and Carcinomas
- Radiology practices and education
- Acute Ischemic Stroke Management
- Aortic Disease and Treatment Approaches
- Peripheral Artery Disease Management
- Nuclear Physics and Applications
University of Arizona
2017-2025
Banner - University Medical Center Tucson
2017-2025
University of Massachusetts Chan Medical School
2008-2017
Emory University
2003-2017
University of Rochester Medical Center
2012-2015
UMass Memorial Health Care
2000-2015
Harvard University
2015
Technion – Israel Institute of Technology
2015
Boston Children's Hospital
2015
Istituto Nazionale di Fisica Nucleare, Sezione di Pisa
2015
This topical review on digital breast tomosynthesis (DBT) is provided with the intent of describing state art in terms technology, results from recent clinical studies, advanced applications, and ongoing efforts to develop multimodality imaging systems that include DBT. Particular emphasis placed studies. The observations increase cancer detection rates, particularly for invasive cancers, reduction false-positive rates DBT prospective trials indicate its benefit screening. Retrospective...
The physical characteristics of a clinical prototype amorphous silicon‐based flat panel imager for full‐breast digital mammography have been investigated. employs thin thallium doped CsI scintillator on an silicon matrix detector elements with pixel pitch 100 μm. Objective criteria such as modulation transfer function (MTF), noise power spectrum, detective quantum efficiency (DQE), and equivalent quanta were employed this evaluation. presampling MTF was found to be 0.73, 0.42, 0.28 at 2, 4,...
Tomosynthesis of the breast is currently a topic intense interest as logical next step in evolution digital mammography. This study reports on computation glandular radiation dose tomosynthesis breast. Previously, estimations have been performed using data from studies conventional planar evaluates, Monte Carlo methods, normalized to during study, and characterizes its dependence size, tissue composition, x‐ray spectrum. The conditions imaging were simulated computer program based Geant4...
To prospectively determine the radiation dose to organs of body during standard bilateral two-view mammography by using Monte Carlo simulations and a phantom.A modified version Cristy mathematic anthropomorphic phantom was implemented in Geant4 tool kit simulate conditions present screen-film digital mammography. The breast simulated with compression both craniocaudal mediolateral oblique views. X-rays were tracked from source until their absorption or detector exit simulation limits,...
Thromboembolic complications remain a limitation of flow diverting stents. We hypothesize that phosphorilcholine surface modified diverters (Pipeline Flex with Shield Technology, sPED) would have less acute thrombus formation on the device compared classic Pipeline Embolization (cPED).Elastase-induced aneurysms were created in 40 rabbits and randomly assigned to receive cPED or sPED devices without dual antiplatelet therapy (DAPT) (four groups, n=10/group). Angioplasty was performed enhance...
Digital tomosynthesis of the breast is being investigated as one possible solution to problem tissue superposition present in planar mammography. This imaging technique presents various advantages that would make it a feasible replacement for mammography, among them similar, if not lower, radiation glandular dose breast; implementation on conventional digital mammography technology via relatively simple modifications; and fast acquisition time. One significant must overcome, however,...
Purpose: To determine the mean and range of volumetric glandular fraction (VGF) breast in a diagnostic population using high‐resolution flat‐panel cone‐beam dedicated CT system. This information is important for Monte Carlo‐based estimation normalized dose coefficients investigating dependence VGF on dimensions, race, pathology. Methods: Image data from clinical trial role that enrolled 150 women were retrospectively analyzed to VGF. The study was conducted adherence protocol approved by...
Background and Purpose— Noninvasive imaging identifying a predictive biomarker of the bleeding risk unruptured intracranial aneurysms (UIAs) is needed. We investigated potential UIA instability, myeloperoxidase, in human aneurysm tissue. Methods — Human brain were harvested after clipping histologically biochemically evaluated for presence myeloperoxidase. Of tissue collected, 3 from ruptured 20 UIAs. For each UIA, its 5-year rupture was determined using Population, Hypertension, Age, Size...
Background Axial computed tomography (CT) cross-sections offer an accessible model for assessing diverse pathologies associated with hyperostosis frontalis interna (HFI) based on the Hershkovitz classification. Purpose To delineate CT characteristics of HFI, emphasizing a radiological description using It investigated whether classification can be predicted density, variable unexplored in literature. HFI thickness and presence concurrent beyond frontal bone (HBFB) were evaluated across...
Abstract Objective. To determine the minimum detector width along fan-angle direction in offset-detector cone-beam breast CT for multiple advanced reconstruction algorithms and to investigate effect on radiation dose, scatter, image quality. Approach. Complete sinograms (m × n = 1024 768 pixels) of 30 clinical datasets previously acquired a clinical-prototype system were reconstructed using Feldkamp-Davis-Kress (FDK) algorithm served as reference. retrospectively truncated varying widths...
This study retrospectively analyzed the mean glandular dose (MGD) to 133 breasts from 132 subjects, all women, who participated in a clinical trial evaluating dedicated breast CT diagnostic population. The was conducted adherence protocol approved by institutional review boards and participants provided written informed consent. Individual estimates of MGD each obtained combining x-ray beam characteristics with dimensions fibroglandular fraction volumetric images, using normalized...
The goal of this study is to combine temporary endovascular bypass (TEB) with a novel shear-activated nanotherapeutic (SA-NT) that releases recombinant tissue-type plasminogen activator (r-tPA) when exposed high levels hemodynamic stress and determine if approach can be used concentrate r-tPA at occlusion sites based on shear stresses created by stent placement.A rabbit model carotid vessel was test the hypothesis SA-NT treatment coupled TEB provides recanalization rates while reducing...
<h3>BACKGROUND AND PURPOSE:</h3> Developments in flat panel angiographic C-arm systems have enabled visualization of both the neurovascular stents and host arteries great detail, providing complementary spatial information addition to conventional DSA. However, visibility these structures may be impeded by artifacts generated adjacent radio-attenuating objects. We report on use a metal artifact reduction algorithm for high-resolution contrast-enhanced conebeam CT follow-up imaging...
Flow diverters for the treatment of posterior circulation aneurysms remain controversial. We aimed to identify factors contributing outcome measures in patients treated with Surpass flow diverter this location.We conducted an observational study 53 who underwent flow-diverter at 15 centers. Key were mortality, complete aneurysm occlusion, and modified Rankin Scale score follow-up.At follow-up (median, 11.3 months; interquartile range, 5.9-12.7 months), 9 had died, resulting all-cause...
Vascular remodeling in response to implantation of a tissue engineering scaffold such as flow diverter (FD) leads the cure intracranial aneurysms. We hypothesize that vascular is dependent on FD design, and CD34+ progenitor cells play an important role endothelialization implant.Sixteen rabbit aneurysms were randomly treated with two different single-layer braided FDs made cobalt-chrome alloys. The FD-48 FD-72 devices had 48 72 wires, respectively. Aneurysm occlusion rate was assessed during...
Background Advances in abdominal MRI have enabled rapid, free-breathing imaging without the need for intravenous or oral contrast material. The use of as primary modality suspected appendicitis has not been previously studied. Purpose To determine diagnostic performance initial children having acute appendicitis. Materials and Methods study included consecutive patients 18 years age younger presenting with pain at a tertiary care institution from January 2013 through June 2016 who...
PURPOSE: To compare the contrast-detail (CD) characteristics of screen-film (SF) and postprocessed digital images by using a phantom-based method. MATERIALS AND METHODS: Images CD phantom with polymerized methyl methacrylate were acquired SF full-field mammography systems at matched exposure conditions. A four-alternative forced-choice experiment was conducted seven observers participating in study. Each observer required to identify randomly located disks from which detection curves...
To determine the mean and range of location-averaged breast skin thickness using high-resolution dedicated CT for use in Monte Carlo-based estimation normalized glandular dose coefficients.This study retrospectively analyzed image data from a clinical investigating CT. An algorithm similar to that described by Huang et al. ["The effect determined on mammographic dosimetry," Med. Phys. 35(4), 1199-1206 (2008)] was used 137 volumes 136 women. The each estimated population were determined....