Purpose Identify features on preoperative computed tomography (CT) scans to predict suboptimal primary cytoreduction in patients treated for advanced ovarian cancer institution A. Reciprocally cross validate the predictors identified with those from two previously published cohorts institutions B and C. Patients Methods Preoperative CT stage III/IV epithelial who underwent A between 1999 2005 were retrospectively reviewed by radiologists blinded surgical outcome. Fourteen criteria assessed....

<h3>BACKGROUND AND PURPOSE:</h3> Mechanical behavior of the thromboembolus is one key factors that determine efficacy thrombectomy devices for revascularization in AIS. We characterized mechanical properties and composition thromboemboli from clinical cases compared them with commonly used EAs. <h3>MATERIALS METHODS:</h3> Thromboemboli were obtained patients AIS by using aspiration carotid atherosclerotic plaques harvested during endarterectomy. In laboratory, common EAs created varying...

The purpose of this study was to investigate the periprocedural morbidity, mortality, and long-term clinical angiographic follow-up using stent-assisted coiling stenting alone for treatment cranial fusiform dissecting atherosclerotic aneurysms.The Institutional Review Board approved study. A retrospective analysis performed 30 aneurysms treated in 28 patients (20 females; mean age, 52.6 years). Eleven (37%) were located posterior circulation. Twenty-one (70%) originated from arterial...

Background and Purpose— Noninvasive imaging identifying a predictive biomarker of the bleeding risk unruptured intracranial aneurysms (UIAs) is needed. We investigated potential UIA instability, myeloperoxidase, in human aneurysm tissue. Methods — Human brain were harvested after clipping histologically biochemically evaluated for presence myeloperoxidase. Of tissue collected, 3 from ruptured 20 UIAs. For each UIA, its 5-year rupture was determined using Population, Hypertension, Age, Size...

Background Poor vessel wall apposition of flow diverter (FD) stents poses risks for stroke-related complications when treating intracranial aneurysms, necessitating long-term surveillance imaging. To facilitate quantitative evaluation deployed devices, a novel algorithm is presented that generates intuitive two-dimensional representations from either high-resolution contrast-enhanced cone-beam CT (VasoCT) or intravascular optical coherence tomography (OCT) images. Methods VasoCT and OCT...

Progress in clinical development of magnetic resonance imaging (MRI) substrate-sensors enzymatic activity has been slow partly due to the lack human efficacy data. We report here a strategy that may serve as shortcut from bench bedside. tested ultra high-resolution 7T MRI (µMRI) surgical histology sections 3-year IRB approved, HIPAA compliant study surgically clipped brain aneurysms. µMRI was used for assessing detect myeloperoxidase inflammation. The Gd-5HT-DOTAGA, novel (MPO) agent...

Dantrolene is neuroprotective in animal models and may attenuate cerebral vasospasm (cVSP) human aneurysmal subarachnoid haemorrhage (aSAH). We evaluated safety, feasibility tolerability of intravenous dantrolene (IV-D) patients with aSAH.In this single-centre, randomised, double blind, placebo-controlled trial, 31 aSAH were randomised to IV-D 1.25 mg every 6 h for 7 days (n=16) or equiosmolar free water/5% mannitol (placebo; n=15). Primary safety end points incidence hyponatraemia (sNa≤132...

Object Intracisternal injection of kaolin is a well-described model feline hydrocephalus. Its principal disadvantage high rate procedure-related morbidity and mortality. The authors describe series modifications to commonly used protocol, intended ameliorate animal welfare concerns without compromising the degree ventricular enlargement. Methods In 11 adult cats, hydrocephalus was induced by into cisterna magna. Kaolin doses were reduced 10 mg, compared with historical ~ 200 high-dose...

Isolated middle cerebral artery dissection is a rare clinical entity, with descriptions limited to few case reports and series. Symptomatic in the anterior circulation can present as an ischemic stroke young population; however, it rarely associated subarachnoid hemorrhage. We describe patient who presented acute headache from hemorrhage that was ultimately determined be due vascular artery. The initial angiogram showed irregularities this area stenosis. Repeat imaging 4 days after...

Isolated middle cerebral artery dissection is a rare clinical entity, with descriptions limited to few case reports and series. Symptomatic in the anterior circulation can present as an ischemic stroke young population; however, it rarely associated subarachnoid hemorrhage. We describe patient who presented acute headache from hemorrhage that was ultimately determined be due vascular artery. The initial angiogram showed irregularities this area stenosis. Repeat imaging 4 days after...

Bolivia, one of the poorest countries in world, ranks 108th on 2013 Human Development Index. With approximately 1 neurosurgeon per 200,000 people, access to neurosurgery Bolivia is a growing health concern. Furthermore, nonindustrialized has been considered both cost-prohibitive and lacking outcomes evaluation. A non-governmental organization (NGO) supports spinal procedures (Solidarity Bridge), authors sought determine its impact cost-effectiveness.In retrospective review prospectively...

Object The aim of this study was to explore the possibility that a hybrid aneurysm clip with polymeric jaws bonded metal spring could provide mechanical properties comparable those an all-metal as well diminished artifacts on computed tomography (CT) scanning. Methods Three clips were created, and Clips 1 2 tested for properties. Clip consisted Elgiloy (a cobalt-chromium-nickel alloy) carbon fiber limbs; polymethylmethacrylate (PMMA) jaws; 3 PMMA limbs identical in but titanium spring....

Takotsubo cardiomyopathy (TC) is a rare, transient cardiomyopathy, with symptoms mimicking myocardial infarction. It has been reported to typically occur in postmenopausal women and often triggered by an intense physical or emotional event stimulation of the sympathetic response; exact etiology, however, uncertain. Bone morphogenic protein (BMP) widely used spinal fusions associated numerous perioperative complications. BMP known stimulate pathways. In this paper, we present case patient...

SYMPTOMATIC MIDDLE FOSSA cysts have not previously been described as complications of temporal lobectomy that has performed to control complex partial seizures. A patient is who developed a middle fossa cyst causing mass effect, intracranial hypertension, and neurological deterioration>2 years after for An enlarging with cerebrospinal fluid imaging characteristics was detected on neuroimages 1 year before deterioration. The treated by the insertion cystoperitoneal shunt diversion. potential...

Massachusetts' health insurance mandate and subsidized program, Commonwealth Care, have been active for 2 years.The financial impact on the neurosurgery division demographics of relevant patient groups were assessed. The billing records neurosurgical patients from January 2007 to September 2008 collected analyzed.Commonwealth Care comprised 2.2% inpatients, these did not significantly different acuity or lengths stay average. Length MassHealth was greater, although lower than Increased free...

Right frontal injury often has been associated with development of manic behavior. Reports similar behavior change left-sided damage are rare. We report a patient who developed hypomania after removal an arteriovenous malformation (AVM) from the left lobe. A 41-year-old right-handed computer programmer crescendo bitemporal headaches brought on by lying down. Medical history included excision occipital meningocele at 3 weeks age, brief loss consciousness in sporting accident, and sinus...

A 73-year-old man presented with cervical cord compression resulting from a metastatic spindle cell thymoma 10 years after undergoing thymectomy for thymoma-associated myasthenia gravis. After being virtually asymptomatic following thymectomy, his myasthenic symptoms returned 3 months removal of the spinal metastasis, culminating in crisis that required immunosuppression and plasma exchange This case shows isolated, extrathoracic metastases without any mediastinal tumor may occur many...

<b><i>Article abstract</i></b> The intracarotid amobarbital test (IAT) is used to lateralize language function and assess hemispheric memory. In this study 23 nonlesional epileptic patients were evaluated. magnitude of the difference in IAT scores between two hemispheres was significantly greater whose seizures lateralized on scalp or intracranial EEG than with bihemispheric seizure onset. This suggests that useful not only predicting focus, but onset as well.

Introduction: Dantrolene is neuroprotective in animal models and may attenuate cerebral vasospasm (cVSP) after aneurysmal subarachnoid hemorrhage (aSAH) humans. We evaluated safety/tolerability feasibility of intravenous dantrolene (IV-D) aSAH. Methods: In this single-center, randomized, double-blind, placebo-controlled trial, 31 patients with acute aSAH were randomized to IV-D 1.25 mg IV every 6 hours x 7 days (n=16) or placebo (n=15). Primary endpoint was incidence hyponatremia (sNa ≤ 134...

Introduction: Dantrolene is neuroprotective in animal models and may attenuate cerebral vasospasm (cVSP) after aneurysmal subarachnoid hemorrhage (aSAH) humans. We evaluated safety/tolerability feasibility of intravenous dantrolene (IV-D) aSAH. Methods: In this single-center, randomized, double-blind, placebo-controlled trial, 31 patients with acute aSAH were randomized to IV-D 1.25 mg IV every 6 hours x 7 days (n=16) or placebo (n=15). Primary endpoint was incidence hyponatremia (sNa ≤ 134...

In some scenarios, such as complex revisions or tumor cases, intralaminar screw placement in the upper thoracic spine can be used to supplement replace traditional pedicle placement. Despite theortic feasibility of placing these screws, no thorough anatomic study has evaluated morphology T1 lamina for Anatomic data lamina, including height, width (the upper, middle, and lower one-third segments), length (with without penetration facet articulation) were analyzed 112 vertebrae. The screws...

Primary malignant fibrous histiocytomas are rare. The authors report on a 56‐year‐old man who presented with neurological symptoms due to cerebral metastasis of pnmary histiocytoma the lung.