A5031378203- Wound Healing and Treatments
- Dermatology and Skin Diseases
- Psoriasis: Treatment and Pathogenesis
- Diabetic Foot Ulcer Assessment and Management
- Asthma and respiratory diseases
- Cytokine Signaling Pathways and Interactions
- Traditional Chinese Medicine Analysis
- Hair Growth and Disorders
- Allergic Rhinitis and Sensitization
- Periodontal Regeneration and Treatments
- Kruppel-like factors research
- Tendon Structure and Treatment
- Hedgehog Signaling Pathway Studies
- Flavonoids in Medical Research
- Natural Compounds in Disease Treatment
- Mesenchymal stem cell research
- Cancer-related molecular mechanisms research
- Pharmacological Effects of Natural Compounds
- Urticaria and Related Conditions
- Pressure Ulcer Prevention and Management
- Phytochemistry and Biological Activities
- TGF-β signaling in diseases
- Retinoids in leukemia and cellular processes
- Acupuncture Treatment Research Studies
- Immunotherapy and Immune Responses
Yueyang Hospital
2016-2025
Shanghai University of Traditional Chinese Medicine
2016-2025
Chengdu University
2022
Shanghai University
2011-2019
Lanzhou University Second Hospital
2019
Lanzhou University
2019
University of Colorado Denver
2011-2018
University of Colorado Anschutz Medical Campus
2013-2018
Seventh People's Hospital of Shanghai
2018
Institute of Dermatology
2016
Microneedles (MNs) have become versatile platforms for minimally invasive transdermal drug delivery devices. However, there are concerns about MN-induced skin infections with long-term administration. Using the Langmuir-Blodgett (LB) technique, a simple method depositing antibacterial nanoparticles of various shapes, sizes, and compositions onto MNs is developed. This strategy has merits over conventional dip coating techniques, including controlled layers, uniform high coverage,...
Squamous cell carcinomas (SCCs) originate in stratified epithelia, with a small subset becoming metastatic. Epithelial stem cells are targets for driver mutations that give rise to SCCs, but it is unknown whether they contribute oncogenic multipotency and metastasis. We developed mouse model of SCC by targeting two frequent genetic human oncogene Kras(G12D) activation Smad4 deletion, keratin 15-expressing (K15+) cells. show transgenic mice multilineage tumors, including metastatic SCCs....
Triptolide is an active component from a Chinese herb, Tripterygium wilfordii which has been applied for treating immune‐related diseases over centuries. Recently, it was reported that variety of cancer cell lines could be sensitized to DNA‐damage based chemotherapy drugs in combination with treatment. In the present study, we show short time exposure (3 h) Triptolide, did not trigger apoptosis, specifically increase breast cells sensitivity Doxorubicin rather than other including...
The prevalence of psoriasis is increasing, and poses a serious risk to human health quality life. Psoriasis, chronic immune‑mediated skin disease with epidermal hyperkeratosis parakeratosis, associated numerous complications, including metabolic syndromes that are regulated by sirtuins (SIRTs) via deacetylation. As they serve necessary function in inflammation metabolism, SIRTs considered link syndrome. Previous studies have indicated the pathophysiology psoriasis, but date no detailed...
Abstract Wound repair, along with skin appendage regeneration, is challenged by insufficient angiogenesis and neural regeneration. Therefore, promoting both proangiogenic neuro-regenerative therapeutic effects essential for effective wound repair. However, most systems apply these strategies separately or ineffectively. This study investigates the performance of an all-in-one smart dressing (ASD) that integrates angiogenic functional materials multiple biological factors within a light...
Introduction Limited by the specific location of atopic facial dermatitis, treatment options for dermatitis are limited. Our previous research confirms that BiShengZhiYan cream (BSZY cream) can reconstruct damaged skin barrier and strengthen repair ability skin. However, little evidence its efficacy safety is available. Methods analysis A protocol a randomised, double-blind, controlled trial BSZY designed patients with mild-to-moderate dermatitis. We will recruit 130 from Yueyang Hospital...
The aim of the present investigation was to elucidate cellular mechanisms whereby Tanshinone IIA (Tan IIA) leads cell cycle arrest and apoptosis in vitro keratinocytes, target cells psoriasis. Tan inhibited proliferation mouse keratinocytes a dose- time-dependent manner induced apoptosis, resulting S phase accompanied by down-regulation pCdk2 cyclin A protein expression. Furthermore, IIA-induced mitochondrial membrane potential changes were also further demonstrated DNA fragmentation,...
Sheng-ji Hua-yu(SJHY) formula is one of the most useful Traditional Chinese medicine (TCM) in treatment delayed diabetic wound. However, elucidating related molecular biological mechanism how SJHY Formula affects excessive inflammation process re-epithelialization wound healing a task urgently needed to be fulfilled. The objectives this study evaluate effect antagonisic expression pro-/anti-inflammatory factors on transforming growth factor-β(TGF-β) superfamily (activin and follistatin)...
The expression of Smad7, a tumor growth factor-β (TGFβ) antagonist, is increased during cutaneous wound healing. To assess this significance, we temporally induced Smad7 transgene in wounded skin gene-switch-Smad7 transgenic (Smad7 tg) mice. induction epidermal keratinocytes caused an increase keratinocyte proliferation with reduced Smad2 activation, indicating that abrogated TGFβ-mediated inhibition. Additionally, from tg mice exhibited accelerated re-epithelialization, activation...
Abstract Overexpression of RAD51 is found in many cancers including breast cancer and associated with poor survival. Compared normal cells, promoter hyperactive cells indicating that transcriptionally activated. However, little known about the mechanisms factors involved transcription regulation. Transcription corepressor, C‐terminal binding protein 1 (CtBP1), an oncogene repressing a panel tumor suppressors transcription, which contributes to progression. In this study, immunohistochemistry...
Chronic ulcer, including diabetic varicose and pressure negatively affects patients' quality of life. As microbiology plays an important role in the mechanism pathology for chronic wound healing, this study concentrates on microecology environment how Traditional Chinese Medicine (TCM) regulates bacteria. Method. The took samples from 35 patients analyzed bacteria variation before after TCM treatment by 16s rRNA sequencing. All were evaluated aspects α-diversity, β-diversity, Simpson's...