A5101946408- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Eicosanoids and Hypertension Pharmacology
- Cancer-related Molecular Pathways
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Bone health and treatments
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Cancer Genomics and Diagnostics
- Muscle and Compartmental Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Colorectal Cancer Treatments and Studies
- Radiopharmaceutical Chemistry and Applications
- Bone Metabolism and Diseases
- Hormonal Regulation and Hypertension
- Pancreatitis Pathology and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
China Medical University
2014-2023
Dongguan People’s Hospital
2023
Baotou Medical College
2022
Hangzhou Medical College
2022
Zhejiang Provincial People's Hospital
2022
Zhejiang University
2014
The aggressive role of TERT promoter mutations has been well established in differentiated thyroid cancer but not anaplastic (ATC).We tested the mutation status by sequencing genomic tumor DNA and examined its relationship with clinicopathological characteristics ATC.Among 106 American Chinese ATC samples, 1,295,228 C>T (termed C228T) was found 37 (34.9%) cases, 1,295,250 four cases (3.8%), two were mutually exclusive collectively 41 (38.7%). C228T occurred 28 90 (31.1%) wild-type BRAF vs...
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human cancers. Several studies have reported that carbohydrate antigen 19-9 (CA19-9) level a useful marker for predicting prognosis PDAC after resection. However, cutoff value CA19-9 used to predict varied among these reports. The aims this study were evaluate whether serum significant predictor survival and determine optimal prognosis.A total 120 consecutive patients who underwent surgery potentially resectable primary...
The American Joint Committee on Cancer (AJCC) staging system is insufficiently prognostic for operable gastric cancer patients; therefore, complementary factors are under intense investigation. Although the focus immune markers, impact of a single factor minimal, due to complex antitumor responses. A more comprehensive evaluation may engender accurate predictions. We analyzed by immunohistochemical staining in two independent cohorts. association with patients' survival was Kaplan-Meier...
Background. Exosomes are nanometer-sized vesicles with immunomodulatory functions, which released by a diverse range of living cells. Although recent studies have shown that tumor-derived exosomes can suppress the function T cells, molecular mechanisms not well understood. In present study, we investigated role Casitas B lineage lymphoma (cbl) family ubiquitin ligases in gastric cancer exosome-induced apoptosis Jurkat Materials and methods. By serial centrifugation sucrose gradient...
Abstract P‐glycoprotein (P‐gp)‐mediated multi‐drug resistance (MDR) is a major barrier to the effective chemotherapy of many cancers. Recent studies have shown that inhibition PI3K/Akt signalling pathway can reverse P‐gp‐mediated MDR. We investigated expression activated Akt (p‐Akt) in 124 human gastric carcinoma tissue samples. Ubiquitous p‐Akt was recorded majority (88/124). There significant correlation between and P‐gp. In adriamycin‐resistant MDR cell line SGC7901/ADR, increased...
The receptor activator for nuclear factor κB ligand/receptor (RANKL/RANK) pathway is critical RANK-expressing cancer cells to home bones, and c-Src progression. objective of this study was explore the effect in RANKL/RANK migration activity human breast cells. Breast cell lines MCF-7, MDA-MB‑231 BT-474 were obtained cultured. Flow cytometry used examine RANK expression. results showed that expressed BT-474, soluble RANKL (sRANKL)-triggered by activating ERK1/2, Akt c-Src. sRANKL-induced...
It is not clear whether polymyxin B/tigecycline (PMB/TGC) combination better than PMB or TGC alone in the treatment of hospital-acquired pneumonia (HAP) caused by carbapenem-resistant organisms (CROs).We conducted a multicenter, retrospective cohort study patients with HAP CROs. The primary outcome was 28-day mortality, and secondary outcomes included clinical success incidence acute kidney injury (AKI). Multivariate Cox regression analysis performed to examine relationship between...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor factor family that induces apoptosis in cancer cells. However, gastric cells are insensitive to TRAIL. In present study, we show pretreatment with IFN-α enhanced TRAIL-induced MGC803 up-regulated death receptor 5 (DR5) expression and down-regulated survivin expression. Furthermore, extracellular-regulated protein kinase (ERK1/2) activation was induced by IFN-α, combination TRAIL led further ERK1/2....
Background It was recently reported that receptor activator for nuclear factor κ B ligand (RANKL)/receptor (RANK) pathway is critical RANK-expressing cancer cells to home bone and associates with disease progression of cancer. The present study aimed evaluate the effect RANK on prognosis in breast patients metastasis visceral metastasis. Methods Immunohistochemical staining carried out paraffin-embedded primary tumour tissue sections from 102 metastatic Survival analysis Cox proportional...
Non-small-cell lung cancer (NSCLC) is the leading global cause of cancer-related death. Due to lack reliable diagnostic or prognostic biomarkers, prognosis NSCLC remains poor. Consequently, there an urgent need explore mechanisms underlying this condition in order identify effective biomarkers. G-protein-signaling modulator 2 (GPSM2) widely recognized as a determinant mitotic spindle orientation. However, its role cancer, especially NSCLC, uncertain. In study, we found that GPSM2 was...
Zhang L, Teng Y, Liu J, Xu Qu Hou K, Yang X, X. c‐Src expression is predictive of poor prognosis in breast cancer patients with bone metastasis but not visceral metastasis. APMIS 2012; 120: 549–57. critical for progression and it particularly important In this study, we aimed to evaluate the effect on metastatic patients, conduct subgroup analysis explore role respectively. We analyzed a total 102 paraffin‐embedded primary tumor tissue sections from using immunohistochemical staining c‐Src,...
Detoxification mechanisms can play a pivotal role in determining tumor cell responses to platinum-based chemotherapy. Glutathione S-transferase-pi (GSTP1) belongs supergene family of detoxifying enzymes involved the prevention DNA damage and subsequent platinum resistance numerous cancers. The GSTP1 gastric cancer sensitivity chemotherapy is, however, not known. In this study, we found that human line MGC803 was significantly more sensitive cis-platinum (CDDP) than other lines examined...
Abstract Background Ligation-assisted endoscopic enucleation (EE-L) was developed for the pathological diagnosis and resection of small gastrointestinal tumors originating from muscularis propria. The technique combines band ligation enucleation. aim this study to evaluate efficacy safety EE-L in Methods A total 43 patients were eligible inclusion June 2009 2011. Endoscopic first performed force tumor assume a polypoid form with pseudostalk. then until completely enucleated Wound closure...
Increased plasma levels of C-reactive protein (CRP) are closely associated with cardiovascular diseases, but whether CRP is directly involved in the pathogenesis atherosclerosis still under debate. Many controversial and contradictory results using transgenic mice rabbits have been published it also unclear lowering can be used for treatment atherosclerosis. In current study, we examined effects rabbit antisense oligonucleotides (ASO) on development WHHL rabbits. ASO led to a significant...
Zinc finger protein 259 (ZNF259) is known to play essential roles in embryonic development and cell cycle regulation. However, its expression pattern clinicopathological relevance remain unclear.A total of 114 lung cancer specimens were collected. The ZNF259 was measured between the tissues adjacent normal by immunohistochemical staining Western blotting. Moreover, correlation with features analyzed cases cancer. Additionally, depleted cells order analyze effect cancer.Immunohistochemical...