A5086109274- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Metastasis and carcinoma case studies
- Lung Cancer Diagnosis and Treatment
- RNA modifications and cancer
- COVID-19 diagnosis using AI
- Colorectal Cancer Treatments and Studies
- Inflammatory Biomarkers in Disease Prognosis
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pharmacological Effects of Natural Compounds
- Gastrointestinal Tumor Research and Treatment
- Cancer, Hypoxia, and Metabolism
- HIV/AIDS Research and Interventions
- Cancer Genomics and Diagnostics
- HIV, Drug Use, Sexual Risk
- AI in cancer detection
- Phytochemicals and Antioxidant Activities
- Chromatography in Natural Products
- Mitochondrial Function and Pathology
China Medical University
2016-2025
First Hospital of China Medical University
2016-2025
Zhejiang Chinese Medical University
2023-2024
Yuhuangding Hospital
2024
Qingdao University
2024
Third Affiliated Hospital of Zhengzhou University
2024
China University of Geosciences
2022
Committee on Publication Ethics
2021
General Hospital of Shenyang Military Region
2017
Jingdong (China)
2017
Abstract Background Computed tomography (CT) is essential for pulmonary nodule detection in diagnosing lung cancer. As deep learning algorithms have recently been regarded as a promising technique medical fields, we attempt to integrate well-trained algorithm detect and classify nodules derived from clinical CT images. Materials Methods Open-source data sets multicenter used this study. A three-dimensional convolutional neural network (CNN) was designed them into malignant or benign diseases...
Abstract Metastasis is the most important reason for poor prognosis of gastric cancer (GC) patients, and mechanism urgently needs to be clarified. Here, we explored a prognostic model estimation tumor-associated mortality in GC patients revealed RNA-binding protein RBMS1 as candidate promoter gene metastasis by analyzing GOBO Oncomine high-throughput sequencing datasets 408 patients. Additionally, was observed with overexpression 85 patient clinical specimens IHC staining further verified...
Abstract Background Circulating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their clinical impact has been limited due to challenges identifying epithelial-mesenchymal transition (EMT)-CTCs using conventional methods. Methods To bridge this knowledge gap, we established a detection platform CTCs based on the distinctive biomarker cell surface vimentin (CSV). A prospective study involving 127 GC patients was conducted,...
Epithelial-mesenchymal transition (EMT) and ferroptosis are two important processes in biology. In tumor cells, they intimately linked. We used single-cell RNA sequencing to investigate the regulatory connection between EMT tendency LUAD epithelial cells. Seurat construct expression matrix using GEO dataset GSE131907 extract found a positive correlation trends of tendency. Then we SCENIC analyze differentially activated transcription factors constructed molecular directed network by causal...
<h3>Importance</h3> An end-to-end efficacy evaluation approach for identifying progression risk after epidermal growth factor receptor (EGFR)–tyrosine kinase inhibitor (TKI) therapy in patients with stage IV<i>EGFR</i>variant–positive non–small cell lung cancer (NSCLC) is lacking. <h3>Objective</h3> To propose a clinically applicable large-scale bidirectional generative adversarial network predicting the of EGFR-TKI NSCLC. <h3>Design, Setting, and Participants</h3> This diagnostic/prognostic...
The gut microbiota has been found to be associated with the risk of lung cancer. However, its causal relationship various types cancer remains unclear.We conducted a Mendelian randomization (MR) study using largest genome-wide association analysis data date from MiBioGen consortium, pooled statistics for Transdisciplinary Research in Cancer Lung, International Lung Consortium, and FinnGen Consortium R7 release data. Inverse variance weighted, weighted model, MR-Egger regression, median were...
Many heroin users do not inject drugs but may still be at risk of infection with human immunodeficiency virus (HIV), hepatitis B (HBV), and C (HCV), via sexual or other noninjection-related activity.Noninjecting (NIUs) in New York City who were recruited prospectively followed during March 1996-February 2003 tested for anti-HIV, anti-hepatitis core antigen, anti-HCV interviewed about their noninjecting risk. A seroconversion is represented by the first positive test result after last...
Abstract Immune checkpoint inhibitor (ICI) rechallenge in non‐small cell lung cancer (NSCLC) is a promising therapeutic strategy. The situation for ICI can be divided into three categories: adverse events (AEs); resistance to ICIs, and becomes compulsive because of tumor relapse while the patients had completed 2 year course immunotherapy. However, these categories are still controversial should explored further. Through voting at 6th Straits Summit Forum on Lung Cancer, this study we...
Background. Exosomes are nanometer-sized vesicles with immunomodulatory functions, which released by a diverse range of living cells. Although recent studies have shown that tumor-derived exosomes can suppress the function T cells, molecular mechanisms not well understood. In present study, we investigated role Casitas B lineage lymphoma (cbl) family ubiquitin ligases in gastric cancer exosome-induced apoptosis Jurkat Materials and methods. By serial centrifugation sucrose gradient...
Abstract Background Hyperfibrinogenemia is a common problem associated with various carcinomas, and accompanied by hypercoagulablity. In advanced non-small-cell lung cancer (NSCLC) it remains unclear whether or not chemotherapy-induced changes in fibrinogen level relate to chemotherapeutic response prognosis. The purposes of this study were to: 1) analyze the association between plasma after first two courses standard first-line platinum-based chemotherapy; 2) evaluate prognostic...
Background Several studies have shown that platelet‐to‐lymphocyte ratio ( PLR ) is a prognostic factor for various cancers. However, there no study about the role of in predicting response to first‐line chemotherapy metastatic gastric cancer. Therefore, this aimed establish whether associated with and survival patients Methods We enrolled 273 diagnosed The best cut‐off value predict chemotherapeutic was chosen by receiver operating characteristic ROC curve analysis. Prognostic significance...
Background Neurolytic splanchnic nerve block is used to manage pancreatic cancer pain. However, its impact on survival and quality of life remains controversial. The authors’ primary hypothesis was that pain relief would be better with a block. Secondarily, they hypothesized analgesic use, survival, might affected. Methods This randomized, double-blind, parallel-armed trial conducted in five Chinese centers. Eligible patients suffering from moderate severe conditions were randomly assigned...
Abstract Background: IBI351 (GFH925) is an irreversibly covalent inhibitor of KRASG12C. Data from prior data cutoffs (primary: Feb, 2022; initial update: July, 2022) showed that was well-tolerated and demonstrated promising efficacy in patients (pts) with advanced solid tumors harboring KRAS p.G12C mutation. Here, we update results this phase I study evaluating pts again. Methods: Pts locally advanced, recurrent or metastatic KRASG12C mutation for whom standard therapy had failed were...
Background Low birthweight (BW) and childhood growth have been hypothesized to be associated with an increased risk of hypertension in later life.