A5101830824- Gallbladder and Bile Duct Disorders
- Connexins and lens biology
- SARS-CoV-2 and COVID-19 Research
- Cancer-related Molecular Pathways
- Nanoplatforms for cancer theranostics
- Pediatric Hepatobiliary Diseases and Treatments
- Viral gastroenteritis research and epidemiology
- RNA modifications and cancer
- Animal Virus Infections Studies
- Cancer Immunotherapy and Biomarkers
- Bone Metabolism and Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ferroptosis and cancer prognosis
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Biomarkers in Disease Mechanisms
- Heat shock proteins research
- Phosphodiesterase function and regulation
- Cancer, Lipids, and Metabolism
- Esophageal and GI Pathology
- Cell death mechanisms and regulation
- Bone health and osteoporosis research
- Natural Compounds in Disease Treatment
- Melanoma and MAPK Pathways
Chinese Academy of Agricultural Sciences
2023-2025
Lanzhou Veterinary Research Institute
2023-2025
Affiliated Zhongshan Hospital of Dalian University
2015-2024
Shanghai East Hospital
2021-2024
Sichuan University
2022
West China Hospital of Sichuan University
2022
Inner Mongolia Medical University
2022
First Affiliated Hospital of Xiamen University
2013
Abstract Background Circulating tumor cells (CTCs) hold immense promise in guiding treatment strategies for advanced gastric cancer (GC). However, their clinical impact has been limited due to challenges identifying epithelial-mesenchymal transition (EMT)-CTCs using conventional methods. Methods To bridge this knowledge gap, we established a detection platform CTCs based on the distinctive biomarker cell surface vimentin (CSV). A prospective study involving 127 GC patients was conducted,...
As a systemic skeletal dysfunction, osteoporosis (OP) is characterized by low bone mass and microarchitectural damage. The global incidences of OP are high.Data were retrieved from databases like Gene Expression Omnibus (GEO), GeneCards, Search Tool for the Retrieval Interacting Genes/Proteins (STRING), Profiling Interactive Analysis (GEPIA2), other databases. R software (version 4.1.1) was used to identify differentially expressed genes (DEGs) perform functional analysis. Least Absolute...
Abstract Here we show that A-kinase anchoring protein 95 (AKAP95) and connexin 43 (Cx43) dynamically interact during cell cycle progression of lung cancer A549 cells. Interaction between AKAP95 Cx43 at different phases was examined by tandem mass spectrometry(MS/MS), confocal immunofluorescence microscopy, Western blot, co-immunoprecipitation(Co-IP). Over the course a complete cycle, interaction occurred in two stages: binding stage from late G1 to metaphase, separating anaphase G1. The...
COVID-19 pandemic caused by the SARS-CoV-2 which is well-publicized cross-species transmissibility. belongs to genus Betacoronavirus, several pathogenic alphacoronaviruses have shown similar patterns of emergence. Much less attention paid host factors required for alphacoronavirus replication compared those betacoronaviruses. Here, we utilized a genome-wide CRISPR-Cas9-based screen identify TMEM198 as critical protein double-membrane vesicle (DMVs) formation during swine alphacoronavirus....
Reprogramming of lipid metabolism is closely associated with tumor development, serving as a common and critical metabolic feature that emerges during evolution. Meanwhile, immune cells in the microenvironment also undergo aberrant metabolism, altered has an impact on function status cells, further promoting malignant biological behavior. Consequently, we focused metabolism-related genes for constructing novel prognostic marker evaluating prostate cancer.Information about cancer patients was...
Pancreaticobiliary reflux (PBR) causes chronic inflammation of the gallbladder mucosa and changes in bile components, which are known to promote gallstone formation. This study aimed investigate biochemistry patients with PBR provide new clues for research on involvement formation.Patients undergoing surgery gallstones between December 2020 May 2021 were eligible inclusion. The (including amylase, lipase, triglyceride, cholesterol, free fatty acids [FFAs], alanine aminotransferase [ALT],...
Swine acute diarrhea syndrome coronavirus (SADS-CoV) is a newly discovered emerging alphacoronavirus. SADS-CoV shares over 90% genome sequence identity with bat alphacoronavirus HKU2. was associated severe and high mortality rates in piglets. Accurate serological diagnosis of infection key managing the SADS-CoV. However, thus far there have been no effective antibody-based diagnostic tests for diagnose exposure. Here, monoclonal antibody (MAb) 6E8 against N protein accurately recognized...
To assess the expression levels of exchange protein 1 directly activated by cAMP (Epac1) and phosphodiesterase 4 (PDE4) in rectal carcinoma, their associations with clinicopathological indexes. In addition, PDE4 Epac1 A-kinase anchor 95, connexin 43, cyclin D1, E1 were evaluated. The PV-9000 two-step immunohistochemistry method was used to determine 44 carcinoma tissue samples 16 paracarcinoma specimens. positive rate tissues higher than that (59.09% vs. 12.5%, P < 0.05). Similar findings...
Background: Occult pancreaticobiliary reflux (OPBR) has a significant correlation with diseases of the gallbladder and biliary system. This study examined incidence OPBR by age in patients benign diseases. Methods: We assessed 475 who underwent surgery at Shanghai East Hospital from December 2020 to 2021. Bile samples collected during were tested for amylase. Patients bile amylase >110 U/L (n = 64) classified as group; rest 411) controls. Results: Of participants, 375 had stone (GS), 170...
Objectives. To assess A-kinase anchor protein 95 (AKAP95), B-Raf, extracellular regulated kinases 1/2 (ERK1/2), and Elk-1 expression in colon cancer tissue, characterize AKAP95 associations with ERK1/2, Elk-1, clinicopathological indices. Methods. The immunohistochemistry streptavidin-perosidase (SP) method was used to determine levels 64 32 para-carcinoma tissue specimens. Results. (1) Positive rates were higher when compared (92.19% vs. 59.38%, <math...
The exchange protein directly activated by cAMP (Epac1), a downstream target of the second messenger cAMP, modulates multiple biological effects alone or in cooperation with kinase A (PKC). Epac1 is necessary for promoting C (PKC) translocation and activation. aim study was to assess intensity immunoreactivity lung cancer para-carcinoma tissues, their associations clinical-pathological indexes. Correlations between Epac1, PKC, A-kinase anchor 95 (AKAP95) connexin43 (Cx43) were also...
In the present study, we developed a nano-integrated diagnostic and therapeutic platform with oxidation-reduction reactions in tumor microenvironments (TMEs). The proposed resolved contradiction of particle size between enhanced permeability retention (EPR) effect interstitial penetration, as well poor circulation low drug-loading efficiency. Flower-like MnO2 NPs were used core modified hyaluronate (HA) H2PtCl6 to obtain MnO2-HA@H2PtCl6 (MHP). maximum efficiency rate reached 35% due its...
Hyperbaric oxygen therapy (HBOT) has been widely used in the treatment of hypoxia, ischemia, and a series diseases caused by hypoxia ischemia. The effect HBOT on gliomas remains controversial. presence local is main cause tumor resistance to radiotherapy chemotherapy; can improve content these areas, thus, should be as effective other hypoxic diseases; however, most researchers believe that process gliomas, efficacy alone limited, usually not alone. More commonly, commonly adjuvant...