A5006551010- Cancer-related gene regulation
- RNA modifications and cancer
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Alzheimer's disease research and treatments
- Medicinal Plants and Bioactive Compounds
- Cancer-related molecular mechanisms research
- Down syndrome and intellectual disability research
- Laser Applications in Dentistry and Medicine
- Heat shock proteins research
- Prostate Cancer Diagnosis and Treatment
- Marine and Coastal Research
- Immune Response and Inflammation
- Urinary Bladder and Prostate Research
- Signaling Pathways in Disease
- Gene Regulatory Network Analysis
- Cancer, Stress, Anesthesia, and Immune Response
- Cancer Immunotherapy and Biomarkers
- Mangiferin and Mango Extracts
- Cell Adhesion Molecules Research
- Obstructive Sleep Apnea Research
- Wnt/β-catenin signaling in development and cancer
- Orthodontics and Dentofacial Orthopedics
Qilu Hospital of Shandong University
2019-2025
Shandong University
2024
Chinese People's Liberation Army
2014
Zhangjiakou Academy of Agricultural Sciences
2011
Hypopharyngeal squamous cell carcinoma (HSCC) is a kind of head and neck (HNSCC) with poor prognosis. Metabolic reprogramming may regulate the tumor microenvironment (TME) by adapting quickly to cellular stress regulating immune response, but its role in HSCC has not been reported. We used nCounter ® Pathways Panel investigate metabolic reprogramming, stress, their relationship tissues adjacent normal tissues. Metabolism-related pathways nucleotide synthesis glycolysis were significantly...
Head and neck squamous cell carcinoma (HNSC) is the most common malignant tumor of head neck. Due to insidious nature HNSC lack effective early diagnostic indicators, development novel biomarkers improve patient prognosis particularly urgent. In this study, we explored validated correlation between cytochrome P450 family 4 subfamily F member 12 (CYP4F12) expression levels progression using data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) datasets collected samples. We...
Abstract Glioblastoma (GBM) is the most aggressive glioma, and prone to develop resistance chemotherapy radiotherapy; hence, patients with glioblastoma have a high recurrence rate low 1‐year survival rate. In addition, pathogenesis of complex largely unknown, available treatments are limited. Here, we uncovered fundamental role DYRK1A in regulating NFATC1 GBMs. We found that was highly expressed glioma cells, its expression positively correlated NFATC1. Moreover, inhibition promoted...
Insulin resistance in the brain is a pathological mechanism that shared between Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM). Although aberrant expression phosphorylation of insulin receptor substrate 1 (IRS-1) contribute to resistance, underlying remains elusive. In this study, we used several approaches, including adeno-associated virus-based protein overexpression, immunoblotting, immunoprecipitation, immunohistochemistry, situ proximal ligation assays, investigate...
Coiled-coil domain containing 60 (CCDC60) is a member of the CCDC family, which participates in progression many types cancer. However, prognostic value CCDC60 head and neck squamous cell carcinoma (HNSC) its function tumor immunity remain unclear.CCDC60 expression potential HNSC were evaluated by bioinformatics approaches, was validated human samples. Genetic alteration analysis underlying biological related co-expressed genes analyzed. The impact on regulation immune infiltration...
Aberrant expression and phosphorylation of insulin receptor substrate 1 (IRS-1) contribute to brain resistance. However, the underlying mechanism remains elusive. The signaling Wnt/β-catenin are two critical pathways for normal cellular function, which interact in both peripheral tissues may In this study, we aimed investigate regulation IRS-1 its downstream by primary neurons. We found that Wnt agonist Wnt3a enhances neurons at basal state via up-regulation IRS-1. Moreover, up-regulates...
Abstract Background G protein‐coupled receptor 12 (GPR12) is an orphan with no confirmed endogenous ligands. It plays important roles in both physiological and pathological conditions such as neurogenesis neural inflammation. However, it remains unclear whether GPR12 regulates carcinogenesis progression head neck squamous cell carcinoma (HNSCC), esophageal cancer (EC) hypopharyngeal (HC). Methods The Cancer Genome Atlas (TCGA) database was applied to explore the expression of GPR12....
Abstract Nasal cavity and Nasopharynx are habitats for both the pathogenic non-pathogenic bacteria. Adenoid hypertrophy (AH) is main cause in children, with a high incidence, airflow reduction upper airways. However, limited research exposed impact of AH on nasal microbial compositions. To determine association between microbiota AH, total DNAs were collected extracted from hypertrophic adenoid donors, 16 S rRNA gene region was sequenced. Microbial diversity compared healthy groups enriched...
Head and neck squamous cell carcinoma (HNSCC) is notorious for poor prognoses, effective biomarkers are urgently needed early diagnosis of HNSCC patients. We investigate the role alkaline ceramidase 1 (ACER1) its relationship with immune infiltration in HNSCC. The differential expression clinical prognostic significance ACER1 patients explored using bioinformatics methods verified human samples. Genetic mutation, DNA methylation drug sensitivity linked examined. potential biological function...
<title>Abstract</title> Head and neck squamous cell carcinoma (HNSC) is one of the most common cancers in world, with poor prognosis lack effective biomarkers for early diagnosis. Tyrosylprotein sulfotransferase 1 (TPST1) has been implicated a variety biological processes tumor progression. The differential expressions TPST1 human tumors clinical HNSC were examined via multiple bioinformatics approaches, verified tissues. In addition, series functional assays performed to explore role...
Objective To evaluate the clinical efficacy of green light photoselective vaporization(PVP)combined testicular resection plus anti-androgen treatment on advanced prostate cancer and bladder outlet obstruction.Methods Twenty cases with PVP obstruction were selected as our subjects,who underwent treatment.The information was recorded.Results All patients succeed through surgery.Maximum urinary flow rate (MFR) at pre-operation (2.0 ± 1.0) ml/s,and increased to (14.0 4.5) ml/s after...
Objective To evaluate the clinical curative effect of non-muscle invasive bladder cancer by selective green laser.Methods 80 cases data were retrospective analysis who received laser treatment.Results All operations successful,surgery durations 15-120 min.Patients had basically no intraoperative bleeding,no obturator nerve reflex,without severe complication such as electricity cut syndrome.Postoperative applied pirarubicin perfusion chemotherapy.All patients followed-up for 3 months-1...
Objective To explore the efficacy and safety of greenlight photoselective vaporization prostate (PVP) in high-risk elder patients with benign prostatic hyperplasia (BPH). Methods A total 120 BPH underwent PVP procedure. The operating time, blood 1oss, indwelling catheterization operation-related complications were monitored. variables such as international symptom score (IPSS), Quality life (QOL) score, maximum urinary flow rate (Qmax) residual urine volume (RUV) recorded compared pre-...