A5084420341- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- T-cell and B-cell Immunology
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Pneumonia and Respiratory Infections
- Phagocytosis and Immune Regulation
- Hepatitis C virus research
- Eosinophilic Esophagitis
- Analytical Chemistry and Chromatography
- Immune Response and Inflammation
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Crystallization and Solubility Studies
- Hepatitis B Virus Studies
- Monoclonal and Polyclonal Antibodies Research
- Dermatology and Skin Diseases
- Head and Neck Anomalies
- Heat shock proteins research
- Lung Cancer Research Studies
- Viral-associated cancers and disorders
Anhui Medical University
2025
Qilu Hospital of Shandong University
2023-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Wenzhou City People's Hospital
2024
Sichuan Agricultural University
2021
University of North Carolina at Chapel Hill
2008-2020
Sichuan University
2018
Second Hospital of Shandong University
2018
University of North Carolina Health Care
2017
Yunnan Population and Family Planning Research Institute
2014
The environmental factors that contribute to the development of autoimmune diseases are largely unknown. Endemic pemphigus foliaceus in humans, known as Fogo Selvagem (FS) Brazil, is mediated by pathogenic IgG4 autoantibodies against desmoglein 1 (Dsg1). Clusters FS overlap with those leishmaniasis, a disease transmitted sand fly (Lutzomyia longipalpis) bites. In this study, we show salivary Ags from fly, and specifically LJM11 protein, recognized Abs. Anti-Dsg1 monoclonal derived patients...
Abstract Systemic lupus erythematosus is an autoimmune disease characterized by the presence of autoantibodies. One unique targets immune system in systemic Sm, a ribonucleoprotein present all cells. To understand regulation B cells specific to Sm Ag normal mice, we have generated Ig H chain transgenic mouse (2-12H Tg). 2-12H Tg mice produce for that remain tolerant due ignorance. We demonstrate here anti-Sm can differentiate into Sm-specific peritoneal B-1 tolerant. Differentiation and...
Abstract Since apoptotic cell Ags are thought to be a source of self-Ag in systemic lupus erythematosus, we have examined the role cells regulation and activation B specific for Sm, ribonucleoprotein targeted human murine lupus. Using Ig-transgenic mice that high frequency anti-Sm cells, find injection induces transient splenic response, while simultaneously causing extensive peritoneal death. In contrast, deficient clearance develop chronic response beginning at 1–2 mo age. These expanded...
The NuRD complex contains both chromatin remodeling and histone deacetylase activities. Mice lacking the MTA2 subunit of show developmental defects in pro-B, pre-B, immature B, marginal zone B cells, abnormal germinal center cell differentiation during immune responses. Mta2 inactivation also causes a derepression Igll1 VpreB1 genes pre-B cells. Furthermore, MTA2/NuRD interacts directly with AIOLOS/IKAROS shows striking overlap target human suggesting functional inter-dependence between...
Abstract The etiology of human autoimmune diseases in general remains largely unknown, although the genetic and environmental interplay may be relevant. This applies to skin such as pemphigus phenotypes others. In this group, there is an endemic form foliaceus (also known fogo selvagem [FS]) which pathogenic IgG4 autoantibody response self-antigen desmoglein 1 (Dsg1) cross-reacts with LJM11 sand fly salivary gland Ag. investigation, we dissected repertoires used by FS patients endogenous...
Background The prevalence of drug-resistant tuberculosis (DR-TB) has brought severe challenges to the prevention and control tuberculosis. Studies have explored status antituberculosis drug (ATD) resistance in different regions China. However, few studies focused on DR-TB Sichuan date. Due large population Sichuan, detailed investigations burden are needed. objective this study was investigate characteristics TB isolates from patients with without HIV (TB-HIV TBw/oHIV patients) Chengdu,...
Abstract Background The noninvasive serum markers pepsinogen I (PGI), II (PGII), gastrin-17 (G17), and PGI:PGII ratio (PGR) have recently been proposed as a new tool for predicting various gastric pathologies. Methods A total of 83 gastritis patients confirmed by gastroscopy were enrolled, with 78 undergoing concurrent colonoscopies. control group included 99 healthy subjects. Enzyme-linked immunosorbent assay was used to detect PGI, PGII, G17, PGR. performance serological analysis detecting...
Abstract To determine the regulation of B cells specific for ribonucleoprotein Sm, a target immune system in human and mouse lupus, we have generated mice carrying an anti-Sm H chain transgene (2-12H). Anti-Sm nonautoimmune 2-12H-transgenic (Tg) are functional, but, absence immunization, circulating Ab levels not different from those non-Tg mice. In this report, compare autoimmune MRL/Mp-lpr/lpr (MRL/lpr) bcl-2-22-Tg Activation markers elevated on splenic peritoneal both genetic backgrounds...
Abstract Pemphigus vulgaris (PV) encompasses two clinical phenotypes, one producing mucosal blisters and the other skin lesions (mcPV). The blister-producing PV variant is characterized by autoantibodies against desmoglein (Dsg)3, whereas lesion-producing to Dsg3 Dsg1. present study was aimed at disclosing diversity clonality of anti-Dsg3 response, as well whether B cells are Ag selected. Human-mouse heterohybridomas were generated fusion EBV-transformed or freshly isolated PBLs from six...
Duck hepatitis A virus 1 (DHAV-1) can cause high morbidity and fatal acute infectious in ducklings, which seriously endangers animal husbandry. Viroporin is a small molecular weight hydrophobic transmembrane protein encoded by the virus, that has been suggested to induce autophagy host cells increasing membrane permeability through disturbing ion balance. In this study, we aimed investigate whether DHAV-1 2B DEF with viroporin-like function. Bioinformatics analysis indicated characterized...
Coiled-coil domain containing 60 (CCDC60) is a member of the CCDC family, which participates in progression many types cancer. However, prognostic value CCDC60 head and neck squamous cell carcinoma (HNSC) its function tumor immunity remain unclear.CCDC60 expression potential HNSC were evaluated by bioinformatics approaches, was validated human samples. Genetic alteration analysis underlying biological related co-expressed genes analyzed. The impact on regulation immune infiltration...