A5004963126- Autoimmune Bullous Skin Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Research on Leishmaniasis Studies
- Platelet Disorders and Treatments
- Leprosy Research and Treatment
- Nonmelanoma Skin Cancer Studies
- Eosinophilic Disorders and Syndromes
- Trypanosoma species research and implications
- Dermatological diseases and infestations
- Nail Diseases and Treatments
- Insect symbiosis and bacterial influences
- Toxin Mechanisms and Immunotoxins
- Phytochemistry Medicinal Plant Applications
- Syphilis Diagnosis and Treatment
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Drug-Induced Adverse Reactions
- Dermatology and Skin Diseases
- Science and Education Research
- Contact Dermatitis and Allergies
- Agricultural and Food Sciences
- Health, Nursing, Elderly Care
- Studies on Chitinases and Chitosanases
- Tuberculosis Research and Epidemiology
- Vector-borne infectious diseases
Universidade Federal de Mato Grosso do Sul
2011-2023
Hospital Universitário de Santa Maria
2018-2023
Centro Universitário do Sul de Minas
2019
Institute of Dermatology
2009
King's College School
2009
Hokkaido University
2009
Universidade Federal do Estado do Rio de Janeiro
2009
Ospedale Misericordia e Dolce
2007
Medica (United States)
2007
Medico
2007
We report here a relationship between intramolecular epitope spreading and the clinical onset of endemic form pemphigus foliaceus in Brazilian community with high prevalence incidence disease. Also known as Fogo Selvagem (FS), this disease is characterized by severe skin blistering pathogenic anti–desmoglein-1 (Dsg1) autoantibodies. These autoantibodies bind Dsg1 ectodomain trigger keratinocyte cell detachment, hallmark FS. show that (a) sera from FS patients preclinical stage recognized...
Pemphigus foliaceus is an autoimmune skin disease mediated by autoantibodies against desmoglein 1. The endemic form thought to have environmental cause. Terena reservation of Limão Verde in Mato Grosso do Sul, Brazil, a recently identified focus the disease, with prevalence 3.4 percent population. We tested hypothesis that normal subjects living area antibodies
Endemic pemphigus foliaceus or fogo selvagem (FS) in an organ‐specific autoimmune skin disease characterized by epidermal vesicles and mediated: autoantibodies. Family cases are frequent not everyone living endemic region develops FS suggesting that host factors play a role determining whether exposed individuals will be affected. Because our previous works with Brazilian Mestizos Xavante Indians have shown particular HLA alleles confer increased risk for the disease, we decided to extend...
Pemphigus are intraepidermal autoimmune bullous dermatoses that occur with lesions on the skin and / or mucous membranes. The most frequent types pemphigus vulgaris foliaceus (classic endemic). This consensus aims to present a complete updated review of treatment these two more forms pemphigus, based literature personal experience authors. In moderate severe cases foliaceus, systemic corticosteroid therapy (prednisone prednisolone) is choice. Adjuvant drugs, usually immunosuppressive drugs...
FUNDAMENTOS: Leishmaniose Tegumentar Americana é zoonose de manifestações clínicas variadas, em expansão no Brasil, sendo o estado Mato Grosso do Sul importante área endêmica. OBJETIVOS: Avaliar clínica, epidemiológica e laboratorialmente pacientes com , atendidos Hospital Universitário Maria Aparecida Pedrossian, Universidade Federal Sul, Brasil (HU/UFMS). MÉTODOS: Trata-se um estudo observacional tipo transversal abordagem descritiva analítica. Foram avaliados, retrospectivamente, dados...
Fogo selvagem (FS), the endemic form of pemphigus foliaceus, is a cutaneous autoimmune disease characterized by subcorneal blistering epidermis and production autoantibodies against desmosomal antigen desmoglein-1 (Dsg1). Previously, we showed that mice injected with from FS patients develop skin reproduces clinical, histological, immunological features FS, indicating play an essential role in development this disease. The purpose study was to characterize T-cell response associated FS. We...
Triatoma matogrossensis is a Hemiptera that belongs to the oliveirai complex, vector of Chagas' disease feeds on vertebrate blood in all life stages. Hematophagous insects' salivary glands (SGs) produce potent pharmacologic compounds counteract host hemostasis, including anticlotting, antiplatelet, and vasodilatory molecules. Exposure T. was also found be risk factor associated with endemic form autoimmune skin pemphigus foliaceus, which described same regions where observed Brazil. To...
Fogo selvagem is an autoimmune blistering skin disease that principally occurs among rural Brazilians living in geographically clumped foci. Exposure to hematophagous black flies possibly related the cause of disease. We compared occurrence, proportions, and richness simuliid species immatures biting activity adult females within a recently discovered, high prevalence focus fogo selvagem, Limão Verde Terena Reservation, neighboring regions with no reported cases selvagem. Nine fly were...
Pemphigus foliaceus is a life threatening skin disease that associated with autoimmunity to desmoglein, protein involved in the adhesion of keratinocytes. This endemic certain areas South America, suggesting mediation environmental factors triggering autoimmunity. Among possible factors, exposure bites black flies, particular Simulium nigrimanum has been suggested. In this work, we describe sialotranscriptome adult female S. flies. It reveals complexity salivary potion insect, comprised by...
Com o objetivo de se conhecer a prevalência da infecção por leishmaniose tegumentar americana, e caracterização população atingida, em área transmissão recente, na localidade Boa Sorte, município Corguinho, MS, procedeu-se ao estudo, no período março/91 março/94, tia residente, compreendendo 150 habitantes. Destes, 12 apresentavam lesões suspeitas tegumentar. Em 8 deles foi possível confirmação meio exames parasitológicos. Apenas um paciente apresentou forma mucosa, os demais manifestaram as...
This publication is an update of the "Consensus on therapeutic management atopic dermatitis - Brazilian Society Dermatology" published in 2019, considering novel, targeted-oriented systemic therapies for dermatitis. The initial recommendations current consensus treatment patients with were based a recent review scientific data and was reached after voting. Dermatology invited 31 experts from all regions Brazil 2 international who fully contributed to process. methods included e-Delphi study...
<h3>Background</h3> Macular and lichen amyloidosis are clinical variants of primary localized cutaneous (PLCA). Most cases sporadic, but approximately 10% may be familial. To our knowledge, the clinicopathologic molecular features such pedigrees, however, have not been studied in detail. <h3>Observations</h3> We assessed 2 Brazilian families with either lichen-type (family 1 had 14 affected subjects) or macular-type 7 PLCA. Typically, both onset symptoms was around puberty, pruritus usually...
Atypical mycobacteria are saprophytic organisms not transmitted from person to person, which affect mainly immunosuppressed but also immunocompetent individuals. We present a case of atypical mycobacteriosis after vascular procedure, with widespread cutaneous lesions associated polyarthralgia. Mycobacterium chelonae was identified by the polymerase chain reaction (PCR) method. The patient showed improvement treatment three antibiotics. causes skin invasive procedures. clinical form depends...