A5038963098- Mast cells and histamine
- Urticaria and Related Conditions
- Food Allergy and Anaphylaxis Research
- Asthma and respiratory diseases
- Allergic Rhinitis and Sensitization
- Inflammasome and immune disorders
- Venous Thromboembolism Diagnosis and Management
- Gout, Hyperuricemia, Uric Acid
- Phonetics and Phonology Research
- Blood disorders and treatments
- melanin and skin pigmentation
- Laser Applications in Dentistry and Medicine
- Receptor Mechanisms and Signaling
- Emotion and Mood Recognition
- Atrial Fibrillation Management and Outcomes
- Dermatology and Skin Diseases
- Speech Recognition and Synthesis
- Dermatologic Treatments and Research
- Cytokine Signaling Pathways and Interactions
- Autoimmune Bullous Skin Diseases
- Hematological disorders and diagnostics
- IL-33, ST2, and ILC Pathways
- Neutropenia and Cancer Infections
- Medicinal plant effects and applications
- Monoclonal and Polyclonal Antibodies Research
Baotou Medical College
2009-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2024
Northeastern University
2024
Inner Mongolia University of Science and Technology
2020-2022
Nanjing General Hospital of Nanjing Military Command
2016
Nanjing University
2006-2016
Luteolin is a flavonoid found in many fruits, vegetables, and herbs. The antiinflammatory effects of luteolin have been reported. In this study, the effect on allergic diseases underlying molecular mechanism were investigated. We that inhibits Fc epsilon RΙ (FcεRΙ)- Mas-related G protein-coupled receptor X2 (MRGPRX2)-mediated mast cells (MCs) activation, including degranulation release cytokines vitro. Moreover, reduces degree swelling Evans blue exudation mice paw dose-dependent manner....
Abstract Background Retinoic acid (RA)‐induced dermatitis is the most frequent side‐effect limiting its widespread use. However, exact mechanisms triggering are not fully understood, including role of skin mast cells. The newly discovered Mas‐related G‐protein‐coupled receptor‐X2 (MRGPRX2) in cells mediates pseudoallergic drug reactions several types dermatitis. A possible contribution MRGPRX2 to contact induced by RA has hitherto been examined. Objectives To investigate whether all‐ trans...
Hydroquinone (HQ) is one of the most effective drugs to treat hyperpigmentary disorders, but often causes skin irritation in clinic. Mast cell plays an important role contact dermatitis and triggering pseudo-allergic reactions via MRGPRX2. Whether HQ-induced irritant reaction through activating mast cells MRGPRX2 remains unknown. To investigate verify whether participated HQ effect on which contributed pathogenesis reaction, a mouse model was established observe local systemic inflammation...
microRNAs ale recently discovered,small,non-coding,single-strand RNAs,which can regulate gene expression posttranscriptionally.They are abnormally expressed in many diseases and act as the totalswitchof disease development.Psoriatic lesions have an abnormal microRNA profile when compared with normal skin other chronic inflammatory diseases,such atopic eczema.To investigate role of specific psoriasis may benefit elucidation pathogenesis well development target therapy psoriasis. Key words:...
Background: Topical tacrolimus has been widely used in the treatment of inflammatory and immune dermatoses for its immunosuppression effect. However, a transient irritation like itching, burning induced by is common when initial application, which similar to pseudo-allergic reaction. MAS-related G protein-coupled receptor-X2 (MRGPRX2) mast cells (MCs) mediates drug-induced reaction IgE-independent pruritis chronic skin diseases. Whether MRGPRX2 participates above adverse should be addressed....