A5046526363- Scoliosis diagnosis and treatment
- Spinal Fractures and Fixation Techniques
- Spine and Intervertebral Disc Pathology
- Mesenchymal stem cell research
- Parkinson's Disease and Spinal Disorders
- Protease and Inhibitor Mechanisms
- Signaling Pathways in Disease
- Pelvic and Acetabular Injuries
- Cardiac Fibrosis and Remodeling
- Angiogenesis and VEGF in Cancer
- Bone Metabolism and Diseases
- Cardiovascular Health and Disease Prevention
- NF-κB Signaling Pathways
- Bone health and treatments
- Neutropenia and Cancer Infections
- Connective tissue disorders research
- 3D Printing in Biomedical Research
- Chemokine receptors and signaling
- Peripheral Artery Disease Management
- Periodontal Regeneration and Treatments
- Peptidase Inhibition and Analysis
- Hematopoietic Stem Cell Transplantation
- Bone and Dental Protein Studies
- Cytokine Signaling Pathways and Interactions
- Cervical and Thoracic Myelopathy
Army Medical University
2017-2023
Southwest Hospital
2017-2023
Daping Hospital
2019
National Center for Gene Research
2007
Abstract The enhanced osteogenesis of mesenchymal stem cells (MSCs) modified by expression cytotoxic T lymphocyte-associated antigen 4 (CTLA4) has been shown in previous studies, but the mechanism remains unknown. Here we found that bone repair effect CTLA4 -modified MSCs demineralized matrix (DBM) a rabbit radius defect model was significantly better than observed for unmodified DBM or alone, and periostin (POSTN) higher both vivo vitro. In addition, also treatment with soluble POSTN could...
To evaluate the safety and efficacy of a novel bone cement-injectable cannulated pedicle screw augmented with polymethylmethacrylate in osteoporotic spinal surgery.This study included 128 patients osteoporosis (BMD T-score -3.2±1.9; range, -5.4 to -2.5) who underwent decompression instrumentation polymethylmethacrylate-augmented screw. Postoperative Visual Analogue Scale scores Oswestry Disability Index were compared preoperative values. plain radiographs computed tomography (CT) scans...
Paravertebral muscles (PVM) act as one of the major dynamic factors to maintain human upright activities and play a remarkable role in maintaining balance trunk. Adult degenerative scoliosis (ADS) has become important causes disability elderly population owing changes spinal biomechanics, atrophy degeneration PVM, imbalance spine. Previously, many studies focused on physical evaluation PVM degeneration. However, molecular biological are still not completely known. In this study, we...
Use of allogeneic mesenchymal stem cells (allo-MSCs) in bone tissue engineering strategies can overcome the limitations associated with autologous MSCs, but unfortunately, immunogenicity allo-MSCs leads to a high rate rejection, unless immunosuppressive agents are used. B and T lymphocyte attenuator (BTLA) is newly discovered immunoglobulin superfamily inhibitory receptor, Herpesvirus-entry mediator (HVEM), member tumor necrosis factor receptor family, only ligand BTLA. Both BTLA HVEM widely...
Abstract Background A considerable portion of the elderly population are increasingly afflicted by degenerative spinal deformity (DSD), which seriously affects patient health-related quality life (HRQoL). HRQoL index is used across many studies to show correlations between radio-graphical alignment, disability, and pain in patients with DSD. However, imaged structural represents only one aspect for consideration, namely, disability effect We assessed isokinetic strength trunk muscle...
Bone defects are a common orthopaedic concern, and an increasing number of tissue-engineered bones (TEBs) used to repair bone defects. Allogeneic mesenchymal stem cells (allo-MSCs) as seed in many approaches develop TEB constructs, but the immune response caused by allogeneic transplantation may lead transplant failure. V gamma 4 T (Vγ4T) play important role mediating early stage after transplantation; therefore, we wanted verify whether suppressing Vγ4T herpesvirus entry mediator (HVEM)/B...
The challenge in developing tissue‐engineered bones (TEBs) for clinical applications lies the constraints associated with source and availability of autologous mesenchymal stem cells (MSCs) derived from bone marrow, which creates a bottleneck. While allogeneic MSCs have shown promise TEB applications, their ability to promote growth is notably diminished because inflammatory reaction at transplant site inherent immune response triggered by MSCs. Hence, there pressing need develop methods...
Abstract Background: A considerable portion of the elderly population are increasingly afflicted by degenerative spinal deformity (DSD), which seriously affects patient health-related quality life (HRQoL). HRQoL index is used across many studies to show correlations between radio-graphical alignment, disability, and pain in patients with DSD. However, imaged structural represents only one aspect for consideration, namely, disability effect We assessed isokinetic strength trunk muscle...
Abstract Background: A considerable portion of the elderly population are increasingly afflicted by degenerative spinal deformity (DSD), which seriously affects patient health-related quality life (HRQoL). HRQoL index is used across many studies to show correlations between radio-graphical alignment, disability, and pain in patients with DSD. However, imaged structural represents only one aspect for consideration, namely, disability effect We assessed isokinetic strength trunk muscle...
Abstract Paravertebral muscles (PVM) act as one of the major dynamic factors to maintain human upright activities and play a remarkable role in maintaining balance trunk. Adult degenerative scoliosis (ADS) has become important causes disability elderly population owing changes spinal biomechanics, atrophy degeneration PVM, imbalance spine. Previously, many studies focused on physical evaluation PVM degeneration. However, molecular biological are still not completely known. In this study, we...
BACKGROUND: The incidence rate of degenerative spinal deformity (DSD) has gradually increased in the elderly. Currently, relationship between functional status trunk muscle and spinal-pelvic parameters DSD patients remains unclear. OBJECTIVE: This paper aims to explore two factors provide new clues for exploring mechanism occurrence development DSD. METHODS: A total 41 treated our hospital (DSD group) 35 healthy volunteers (control were selected. Muscle strength was evaluated using an...
BACKGROUND: Degenerative spinal deformity (DSD) is believed to originate from degeneration of the discs and facet joints vertebral wedging. Currently, nosogeny DSD not yet fully clarified there has been no systematic study on impact their lower back muscle strength quality life. OBJECTIVE: To determine characteristics extensor (BES) in different body positions examine correlations with health-related life (HQOL) degenerative patients. METHODS: Participants comprised 60 patients 40 healthy...
Abstract Background: A considerable portion of the elderly population are increasingly afflicted by degenerative spinal deformity (DSD), which seriously affects patient health-related quality life (HQOL). This index is used across many studies to show correlations between radio-graphical alignment, disability, and pain in patients with DSD. However, imaged structural represents only one aspect for consideration, namely, disability effect DSD.We assessed isokinetic strength trunk muscle...
To evaluate the effect of continuous traction with a combined adjustable Halo-pelvic fixation brace on cervical spine alignment in patients severe rigid spinal deformity and analyze its related factors.We conducted retrospective cohort study 21 treated our department between 2015 2019. All subjects received before secondary orthopedic surgery. The influence was evaluated by measuring parameters lateral X-ray at three time points: traction, end 6 months after correlation parameter changes...
An amendment to this paper has been published and can be accessed via a link at the top of paper.