A5100410428- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- 14-3-3 protein interactions
- Immunotherapy and Immune Responses
- Ubiquitin and proteasome pathways
- Angiogenesis and VEGF in Cancer
- RNA Research and Splicing
- Lung Cancer Treatments and Mutations
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Lipid metabolism and biosynthesis
- Neuroscience of respiration and sleep
- Galectins and Cancer Biology
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac Ischemia and Reperfusion
- Cancer-related gene regulation
- Organ Transplantation Techniques and Outcomes
- Connexins and lens biology
- Renal Transplantation Outcomes and Treatments
- Autophagy in Disease and Therapy
Xiangnan University
2007-2025
Shandong Provincial QianFoShan Hospital
2024
Shandong First Medical University
2024
Huazhong University of Science and Technology
2012-2023
Zhengzhou University
2021-2023
Northwest A&F University
2017-2023
Henan Provincial People's Hospital
2021-2023
Henan University
2004-2022
Emory University
2021-2022
Shenzhen Pingle Orthopedic Hospital
2022
As a special form of noncoding RNAs, circular RNAs (circRNAs) played important roles in regulating cancer progression mainly by functioning as miRNA sponge. While the function RNA-ITCH (cir-ITCH) lung is still less reported, this study, we firstly detected expression cir-ITCH tumor tissues and paired adjacent noncancer 78 patients with using TaqMan-based quantitative real-time PCR (qRT-PCR). The results showed that was significantly decreased tissues. In cellular studies, also enhanced...
Circular RNAs (circRNAs) are significantly dysregulated in various cancer types. However, the roles and mechanisms of circRNAs remain largely unknown. In this study, we demonstrated that a novel circRNA (circITGA7) its linear host gene ITGA7 both downregulated colorectal (CRC) tissues cell lines. These decreased expression levels correlated with CRC progression. Functional assays ectopic circITGA7 suppressed growth metastasis cells vitro vivo. Knockdown or promoted proliferation migration...
Super hybrid rice varieties with ideal plant architecture (IPA) have been critical in enhancing food security worldwide. However, the molecular mechanisms underlying their improved yield remain unclear. Here, we report identification of a QTL, qWS8/ipa1-2D, super Yongyou12 (YY12) and related varieties. In-depth genetic characterization qWS8/ipa1-2D reveals that this newly identified QTL results from three distal naturally occurring tandem repeats upstream IPA1, key gene/locus previously...
Lung ischemia/reperfusion (I/R) injury occurs in various clinical conditions and heavily damaged lung function. Oxidative stress reaction antioxidant enzymes play a pivotal role the etiopathogenesis of I/R injury. In current study, we investigated impact Maresin 1 on explored possible mechanism involved this process. MaR ameliorated I/R-induced score, wet/dry weight ratio, myeloperoxidase, tumor necrosis factor, bronchoalveolar lavage fluid (BALF) leukocyte count, BALF neutrophil pulmonary...
Background Recent studies have revealed that circular RNA s are involved in the biological process of some kinds human cancers. However, little is known about their diagnostic values and functions colorectal cancer ( CRC ). Methods The expression levels hsa_circ_0000567 102 paired tissues adjacent noncancerous tissues, 5 cell lines, a normal epithelial line were detected by quantitative real‐time polymerase chain reaction qRT ‐ PCR correlations between clinicopathological factors patients...
CircPVT1 is demonstrated to promote cancer progression in esophageal squamous cell carcinoma (ESCC). However, the role and potential functional mechanisms of circPVT1 regulating 5-fluorouracil (5-FU) chemosensitivity remain largely unknown.ESCC cells resistant 5-FU were induced with continuous increasing concentrations step-wisely. A counting kit-8 assay was used analyze viability ESCC cells. LDH release kit evaluate cytotoxicity. RT-qPCR assess expression level non-coding RNAs cDNAs....
Triple-negative breast cancer (TNBC) cells lack the expression of ER, PR and HER2. Thus, TNBC patients cannot benefit from hormone receptor-targeted therapy as non-TNBC patients, but can only receive chemotherapy systemic treatment have a worse overall outcome. More effective therapeutic targets combination strategies are urgently needed to improve effectiveness. Methods: We analyzed levels EZH2 TET1 in TCGA our own patient cohort, tested their correlation with survival. used cell lines...
As a newly identified oncogenic long noncoding RNA (lncRNA), prostate cancer-associated transcript 6 (PCAT6) promoted cellular proliferation and colony formation of cancer. However, the biological function PCAT6 in lung cancer is still largely unknown. In this study, we found that significantly increased tissues compared to normal positively correlates with metastasis patients. We then examined expression cell lines was elevated cells human bronchial epithelial (NHBE) cells, especially CL1-5...
Abstract Parkinson’s disease (PD), a neurodegenerative disorder characterized by degeneration of the dopaminergic (DA) neurons, is still lack available treatments to completely block neurodegeneration. (−)-Epigallocatechin-3-gallate (EGCG), predominant active polyphenol generated from green tea, exerts multiple neuroprotective roles in nervous system. However, function role EGCG PD and underlying mechanism remains be investigated. In current study, we used rotenone injection build rat model,...
Aloin has the potential to be a novel anticancer agent in cancer therapies. However, detailed effect of remains fully elucidated. The present study analyzed p53‑dependent mechanisms response treatment. Using p53‑proficient A549 cells, an Aloin‑induced apoptotic cell model was established, which used evaluate underlying molecular mechanisms. results demonstrated that 200, 300 and 400 µM induced intrinsic apoptosis, further confirmed by disruption mitochondrial membrane potential, elevation...
The long noncoding RNA (lncRNA) Eosinophil Granule Ontogeny Transcript (EGOT) has been reported to inhibit the proliferation and migration of glioma cells, promote development progression gastric cancer through Hedgehog (Hh) signaling pathway. This study was conducted assess role EGOT in breast cancer. We observed that is significantly down-regulated tissues cell lines, expression negatively correlated with Ki67 expression. Overexpression BT549 cells decreased viability migration. In...
Abstract Background In recent years, an increasing number of studies have indicated that circular RNA plays crucial roles in regulating tumor development and chemoresistance. Using two high-throughput sequence datasets, we previously found circEXOC6B was downregulated colon cancer. However, its role mechanism colorectal cancer (CRC) remained unknown. Methods Real-time quantitative PCR used to examine the expression CRC tissues. vivo vitro functional experiments were performed determine...
Non-small cell lung cancer (NSCLC) accounts for about 85% of all cases. Absence miR-103 has recently been identified to be associated with metastatic capacity primary tumors. However, the exact role in NSCLC and molecular mechanism are unclear. In present study, we showed that expression was reduced tissues cells. negatively correlated tumor size stage. The overall survival longer patients higher level than those lower expression. inhibited proliferation A549 cells, decreased weight volume,...