A5100679479- Neurogenesis and neuroplasticity mechanisms
- PI3K/AKT/mTOR signaling in cancer
- FOXO transcription factor regulation
- Cancer Mechanisms and Therapy
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Plant Pathogens and Fungal Diseases
- Hedgehog Signaling Pathway Studies
- Acupuncture Treatment Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Essential Oils and Antimicrobial Activity
- Genetics and Neurodevelopmental Disorders
- Genomics, phytochemicals, and oxidative stress
- Endoplasmic Reticulum Stress and Disease
- Mycotoxins in Agriculture and Food
- Histone Deacetylase Inhibitors Research
- Circular RNAs in diseases
- Melanoma and MAPK Pathways
- interferon and immune responses
- Synthesis and biological activity
- Natural product bioactivities and synthesis
- Antifungal resistance and susceptibility
- Remote Sensing and Land Use
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood properties and coagulation
The First Affiliated Hospital, Sun Yat-sen University
2025
Sun Yat-sen University
2025
Hangzhou Normal University
2023-2024
Southern Medical University
2020-2024
Nanfang Hospital
2021-2024
Minjiang University
2024
Guangzhou University of Chinese Medicine
2022
Shanghai Changning Maternity and Infant Health Hospital
2021
Shenyang Pharmaceutical University
2013
Zhejiang University
2009
Abnormalities in ether lipid metabolism as well the formation of neutrophil extracellular traps have recently been recognized detrimental factors affecting tumorigenesis and progression. However, role abnormal colorectal cancer (CRC) evolution has not reported. Here we show that metabolism-related gene enoyl-CoA δ-isomerase 2 (ECI2) plays a tumor-suppressor CRC is negatively associated with poor prognosis patients. We mechanistically demonstrate ECI2 reduces lipid-mediated Interleukin 8...
Metastasis is a major cause of death in patients with colorectal cancer (CRC). Cysteine-rich protein 2 (CSRP2) has been recently implicated the progression and metastasis variety cancers. However, biological functions underlying mechanisms CSRP2 regulation CRC are largely unknown. Methods: Immunohistochemistry, quantitative real-time polymerase chain reaction (qPCR) Western blotting (WB) were used to detect expression tissues paracancerous tissues. function was determined by series...
Abstract Background In recent years, an increasing number of studies have indicated that circular RNA plays crucial roles in regulating tumor development and chemoresistance. Using two high-throughput sequence datasets, we previously found circEXOC6B was downregulated colon cancer. However, its role mechanism colorectal cancer (CRC) remained unknown. Methods Real-time quantitative PCR used to examine the expression CRC tissues. vivo vitro functional experiments were performed determine...
Sequence variation produced by mutation provides the ultimate source of natural selection for species adaptation. Unlike nonsynonymous mutation, synonymous mutations are generally considered to be selectively neutral but accumulating evidence suggests they also contribute adaptation regulating flow genetic information and development functional traits. In this study, we analysed sequence characteristics ATP6, a housekeeping gene from 139 Phytophthora infestans isolates, compared fitness...
Curcumol is a representative index component for the quality control of essential oil Curcuma wenyujin Y.H. Chen et C. Ling, an antivirus and anticancer drug in China. Microbial transformation curcumol (1) by Aspergillus niger AS 3.739 yielded two products. Their structures were elucidated as 3alpha-hydroxycurcumol (2) 3alpha-(4'-methoxy-succinyloxy)-curcumol (3) extensive spectroscopic methods including 2D-NMR HRESI-MS. Among them, 3 new compound. Esterification substrate with succinic acid...
Proper axonal myelination and function of the vertebrate central nervous system rely largely on timely differentiation oligodendrocytes (OLs), yet key regulatory factors remain enigmatic. Our study reveals neural zinc finger (Nzf2) as a crucial orchestrator that controls timing OL both during development myelin repair, contrasting with its previously suggested role in direct gene regulation. Nzf2 ablation delays onset differentiation, while hyperactivation stimulates remyelination. Using...
As one of the most common malignant tumor, colorectal cancer (CRC) continues to have a high incidence and mortality rate. HRK belongs BCL-2 protein family, which has been shown antitumor effects in prostate cancer. However, its role is not yet known. In this study, we verified expression levels tissues by public database search as well immunohistochemistry. Next, analyzed CRC tissues,adjacent non-cancerous tissues, cell lines normal intestinal epithelial cells qPCR Western blotting. CCK-8...