Inosine 5'-monophosphate dehydrogenase type II (IMPDH2) was originally identified as an oncogene in several human cancers. However, the clinical significance and biological role of IMPDH2 remain poorly understood colorectal cancer (CRC).Quantitative real-time polymerase chain reaction (qPCR), western blotting analysis, Cancer Genome Atlas (TCGA) data mining immunohistochemistry were employed to examine expression CRC cell lines tissues. A series in-vivo in-vitro assays performed demonstrate...

Leukoaraiosis (LA) refers to white matter hyperintensities or lesions (WMLs) on magnetic resonance imaging (MRI) scans of the brain; this disease is associated with an increased risk stroke, dementia, and cognitive decline. The aims study are assess incidence LA its factors in a Chinese population. A hospital-based cross-sectional was conducted that included 4683 patients who were 40 years older. Data collected age, sex, hypertension, diabetes, smoking, drinking, homocysteine (HCY),...

Leukoaraiosis (LA) manifests as cerebral white matter hyperintensities on T2-weighted magnetic resonance imaging scans and corresponds to lesions or abnormalities in brain tissue. Clinically, it is generally detected the early 40s highly prevalent globally individuals aged >60 years. From perspective, LA can present several heterogeneous forms, including punctate patchy deep subcortical matter; with periventricular caps, a pencil-thin lining, smooth halo; well irregular lesions, which are...

✓ The authors present a statistical survey of the general incidence, age distribution, and preferential sites 25,122 tumors central nervous system (CNS), from 12 centers in China. Of these tumors, 22,457 were intracranial rest intraspinal. neoplasms collected, neuroepithelial tissue comprised 43.85%, meningiomas 16.58%, nerve sheath cells 9.5%, pituitary adenoma 9.52%, congenital 8.46%, secondary 6.8%, vascular malformations 3.82%, primary sarcomas 0.72%. Neuroepithelial meningeal occurred...

Metastasis is a major cause of death in patients with colorectal cancer (CRC). Cysteine-rich protein 2 (CSRP2) has been recently implicated the progression and metastasis variety cancers. However, biological functions underlying mechanisms CSRP2 regulation CRC are largely unknown. Methods: Immunohistochemistry, quantitative real-time polymerase chain reaction (qPCR) Western blotting (WB) were used to detect expression tissues paracancerous tissues. function was determined by series...

Context: Human endometriosis (EMS) is characterized by insufficient apoptosis. Our previous studies have shown elevated CD147 expression in human endometriotic tissues and its involvement endometrial cell However, the exact underlying mechanism remains elusive. Objective: The objective was to examine correlation of highly expressed with anti-apoptotic factor Bcl-2 determine CD147-regulated apoptotic pathway epithelial line (HES). Design: This a laboratory study using tissue analysis HES...

Aim: To explore whether the aberrant DNA methylation status in plasma could be used as a biomarker for hepatocellular carcinoma (HCC) screening among high-risk individuals. Methods: The promoter of ELF, RASSF1A, p16, and GSTP1 was investigated by methylation-specific polymerase chain reaction (PCR) 34 paired HCC nontumor liver tissue from patients 10 tissues with cirrhosis (LC). Plasma samples 31 patients, LC well 7 benign hepatic conditions were also collected characterized using same...

The brother of the regulator imprinted sites (BORIS) is a novel member cancer testis antigen gene family, which are normally expressed only in spermatocytes, but abnormally activated different malignancies.The aim this study was to explore expression BORIS hepatocellular carcinoma (HCC) and its correlation with clinicopathologic features prognosis HCC.We investigated HCC cell lines 105 primary clinical surgical specimens using real-time polymerase chain reaction Western blot analysis. We...

Abstract Organophosphanes promote the [3+2] cycloaddition reactions of dialkyl ( E )‐hex‐2‐en‐4‐ynedioates and [60]fullerene, giving a series cyclopenteno‐fullerenes 3a – k bearing phosphorus ylides. This reaction is initiated by attack nucleophilic phosphanes at α(δ′)‐C atom )‐hex‐2‐en‐4‐ynedioate, which generates 1,3‐dipolar species. These 1,3‐dipoles then react with C 60 followed intramolecular cyclization to give in moderate‐to‐good yields. In cyclic voltmmetry study, these novel...

Abstract Background The cause of almost all cases Parkinson’s disease (PD) remains unknown. Recent years have seen an explosion in the rate discovery genetic defects linked to PD. Different racial and geographical populations may different distributions variants. Methods In current study, we screened following variants, including some rare mutations single nucleotide polymorphisms (SNPs), a pedigree cases-controls. To best our knowledge, first these variants known be associated with...

Endometriotic tissues exhibit high migration ability with the underlying mechanisms remain elusive. Our previous studies have demonstrated that cystic fibrosis transmembrane conductance regulator (CFTR) acts as a tumor suppressor regulating cell migration. In present study, we explored whether CFTR plays role in development of human endometriosis. We found both mRNA and protein expression levels urokinase-type plasminogen activator receptor (uPAR) were significantly increased ectopic...

Leukoaraiosis (LA) is neuroimaging abnormalities of the cerebral white matter in elderly people. However, molecular mechanisms underlying lesions remain unclear. Here, we reported an epigenetic basis and potential pathogenesis for this complex illness. 317 differentially methylated genes were identified to distinguish mechanism occurrence progression LA. Gene-Ontology pathway analysis highlighted that those with changes are mostly involved four major signaling pathways including inflammation...

Objectives The previously reported functional mutation rs75932628-T (p.R47H) in the triggering receptor expressed on myeloid cells 2 (TREM2) is a genetic risk factor for Alzheimer's disease, Parkinson's disease (PD) and frontotemporal dementia, European populations. This study aims to assess association of variant with PD leucoaraiosis (LA) Han Chinese population. Setting population-based was conducted China by Xiamen University its affiliated hospital. Participants 308 patients LA, 342 198...

Aberrant antigen expression in acute myeloid leukemia (AML) has been extensively studied the West with limited reports from Taiwan. We carried out this retrospective study to characterize frequency and significance of aberrant AML Among 111 cases, 58 (52%) showed expression, most frequently CD7 (27%) CD56 (23%). was observed all non-AML-M3 subtypes, AML-M7 (4/6, 67%); while CD19 only AML-M2 (5/36, 14%). common AML-M5 (4/8, 50%). The relative t(8;21) higher than those other chromosomal...

Background: Cerebral cavernous malformations (CCMs) are common vascular that predominantly arise in the central nervous system and mainly characterized by enlarged cavities without intervening brain parenchyma. Familial CCMs (FCCMs) is inherited an autosomal dominant pattern with incomplete penetrance variable symptoms. Methods: Mutations of three pathogenic genes, CCM1, CCM2, CCM3, were investigated direct DNA sequencing a Chinese family multiple CCM lesions. Results: Four heterozygous...

Cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated Cl- channel, is extensively expressed in the epithelial cells of various tissues and organs. Accumulating evidence indicates that aberrant expression or mutation CFTR related to carcinoma development. Malignant gliomas are most common aggressive intracranial tumours; however, role development malignant unclear. Here, we report glioma cell lines. Suppression channel function knockdown suppresses viability whereas...

In mammalian cochlea, sound-induced vibration is amplified by a three-row lattice of Y-shaped microstructures consisting electromotile outer hair cell and supporting Deiters cell. This highly organized structure thought to be essential for hearing low-level sounds. Prior studies reported differences in geometry synaptic innervation the cells between rows, but how these fine features are achieved at subcellular level still remains unclear. Using serial block-face electron microscopy, we...

Abstract Warfarin is a commonly prescribed and effective oral anticoagulant. Genetic polymorphisms associated with warfarin metabolism sensitivity have been implicated in the wide inter-individual dose variation that observed. Several algorithms integrating patients’ clinical characteristics genetic polymorphism information explored to predict dose. However, most of these could explain only over half maintenance dose, suggesting additional factors may exist need be identified. Here, drug...