A5100452680- Natural product bioactivities and synthesis
- Alzheimer's disease research and treatments
- Pharmacological Effects of Natural Compounds
- Hepatitis C virus research
- Plant biochemistry and biosynthesis
- Multiple Myeloma Research and Treatments
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroscience and Neuropharmacology Research
- Toxin Mechanisms and Immunotoxins
- Parkinson's Disease Mechanisms and Treatments
- Glycosylation and Glycoproteins Research
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Lipid Membrane Structure and Behavior
- Kidney Stones and Urolithiasis Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Autoimmune Neurological Disorders and Treatments
- Medical Education and Admissions
- Histone Deacetylase Inhibitors Research
- Maternal Mental Health During Pregnancy and Postpartum
- Supramolecular Self-Assembly in Materials
- Genetic and Kidney Cyst Diseases
Peking University
2014-2025
Tianjin University
2025
Huaqiao University
2025
German Center for Neurodegenerative Diseases
2024
Rocky Vista University
2022
Changhai Hospital
2021
Second Military Medical University
2021
Beijing Union University
2021
Dalian Medical University
2019
Second Affiliated Hospital of Dalian Medical University
2019
Entry inhibitors are of particular importance in current efforts to develop a new generation anti-influenza virus drugs. Here we report certain pentacyclic triterpenes exhibiting conserved structure features and with vitro activity comparable even higher than that oseltamivir. Mechanistic studies indicated these lead triterpenoids bind tightly the viral envelope hemagglutinin (HA), disrupting interaction HA sialic acid receptor thus attachment viruses host cells. Docking suggest binding...
Development of hepatitis C virus (HCV) entry inhibitors represents an emerging approach that satisfies a tandem mechanism for use with other in multifaceted cocktail. By screening Chinese herbal extracts, oleanolic acid (OA) was found to display weak potency inhibit HCV IC50 10 μM. Chemical exploration this triterpene compound revealed its pharmacophore requirement blocking entry, rings A, B, and E, are conserved while ring D is tolerant some modifications. Hydroxylation at C-16...
A few prospective studies have suggested that tea, alcohol, and fruit consumption may reduce the risk of kidney stones. However, little is known whether such associations their combined effect persist in Chinese adults, for whom popular tea alcohol drinks are different from those investigated aforementioned studies. The present study included 502,621 participants China Kadoorie Biobank (CKB). Information about was self-reported at baseline. first documented cases stones during follow-up were...
Abstract Abnormal intraneuronal accumulation of soluble and insoluble α-synuclein (α-Syn) is one the main pathological hallmarks synucleinopathies, such as Parkinson’s disease (PD). It has been well documented that reversible liquid-liquid phase separation α-Syn can modulate synaptic vesicle condensates at presynaptic terminals. However, also form liquid-like droplets may convert into amyloid-enriched hydrogels or fibrillar polymorphs under stressful conditions. To advance our understanding...
Abstract The primary cilia serve as pivotal mediators of environmental signals and play crucial roles in neuronal responses. Disruption ciliary function has been implicated circuit disorders aberrant excitability. However, the precise mechanisms remain elusive. To study link between excitability, manipulation somatostatin receptor 3 (SSTR3) is investigated, an example how alterations signaling may affect activity. It found that SSTR3 expression perturbed not only morphology but also...
To explore the clinical characteristics of noise-induced hearing loss (NIHL) caused by long-term exposure to steady-state noise and find a possible inflection point time leading deterioration. Subjects exposed were selected as noise-exposed group matched with control individuals not noise. Both groups underwent pure-tone audiometry (PTA) distortion product otoacoustic emissions (DPOAE), their conditions analyzed. The most significant disparities in NIHL between early late was evaluated....
Oxidative stress-induced photoreceptor cell death is closely associated with the etiology of age-related macular degeneration (AMD), and sodium iodate (SI) has been widely used as an oxidant stimulus in AMD models to induce retinal pigment epithelium (RPE) death. However, mechanism underlying SI-induced remains controversial unclear. In this study, we elucidate that ferroptosis a critical form induced by SI photoreceptor-derived 661W cells. disrupts system Xc-, leading glutathione (GSH)...
Abstract Bone morphogenetic protein 9 (BMP9), as one of the most potent osteogenic factors, is a promising cytokine for bone tissue engineering. Wnt11 can regulate development skeletal system and related to high mass syndrome. However, effect on BMP9‐induced differentiation remains unknown. In this study, we investigated relationship between Wnt11‐ in mesenchymal stem cells (MSCs). We recapitulated potential BMP9 C3H10T1/2 cells. The messenger RNA expression detectable available progenitor...
The RAF/MEK/ERK pathway is a crucial signal path which closely associated with the proliferation, differentiation, and apoptosis of tumors. MEK1/2 key kinase target in pathway, ERK1/2 acting as main substrate it. Despite rapid development inhibitors, acquired resistance still happens remains significant problem. Most inhibitors possess similar diarylamine scaffold. Here we designed synthesized series degraders based on coumarin derivative was potent non-diarylamine allosteric inhibitor. P6b...
A total of 24 novel sialic acid–pentacyclic triterpene conjugates were synthesized and evaluated as anti-influenza virus entry inhibitors.
The goal of this study was to assess the antitumor efficacy and safety lobaplatin-based regimens as second line treatment in patients with metastatic breast cancer (MBC) resistant anthracyclines taxanes, compared that cisplatin-based regimens. During August 2012 April 2015, 87 who received or were included. Medical records noted lobaplatin (30 mg/m2) cisplatin (25 mg/m2), combined another chemotherapeutic agent such Gemcitabine (1000 Vinorelbine intravenously given on a basis twenty-one days...
Recent economic development in China has been accompanied by well-documented health inequalities between regions. The impact of individual factors on child height widely studied, but the influence community-level not yet fully studied. cross-sectional data 1606 Chinese children aged 5–18 years from Health and Nutrition Survey 2011 were used. Multilevel analysis was used to examine association community (using urbanization index) with height. Child measured following standardized procedures,...
Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by early presence of amyloid-β (Aβ) and hyperphosphorylated tau. Identifying neuropathological changes preceding cognitive decline crucial for intervention. Axon initial segment (AIS) maintains orderly structure axon responsible initiating action potentials (APs). To investigate role AIS in stages AD pathogenesis, we focused on alterations neurons from APP/PS1 mouse models harboring familial mutations....
Background: Cerebral cavernous malformations (CCMs) are common vascular that predominantly arise in the central nervous system and mainly characterized by enlarged cavities without intervening brain parenchyma. Familial CCMs (FCCMs) is inherited an autosomal dominant pattern with incomplete penetrance variable symptoms. Methods: Mutations of three pathogenic genes, CCM1, CCM2, CCM3, were investigated direct DNA sequencing a Chinese family multiple CCM lesions. Results: Four heterozygous...
Alzheimer's disease (AD) is the most frequent neurodegenerative and a common dementia in elderly individuals. Previous studies found strong correlation between axon initial segment (AIS) defects AD, but it remains unclear whether AD itself changes arrangement of AIS components, mechanisms by which adaptor proteins ion channels are disturbed not well understood. With super-resolution structured illumination microscopy (SIM) revealing axonal structures, here we imaged lattice structure...
Alzheimer's disease (AD) is a degenerative of the central nervous system characterized by progressive impairment neural activity. Studies have shown that 3,6'-disinapoyl sucrose (DISS) can alleviate pathological symptoms AD through activation cAMP/CREB/BDNF signaling pathway. However, exact biochemical mechanisms action DISS are not clear. This study explores metabolism in an mouse model, induced microinjection lentiviral expression plasmid APPswe695 gene into CA1 hippocampus. After gavage...