A5101951773- Influenza Virus Research Studies
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Hepatitis C virus research
- Immune Response and Inflammation
- Respiratory viral infections research
- interferon and immune responses
- Chinese history and philosophy
- HIV/AIDS drug development and treatment
- Hepatitis B Virus Studies
- Phytochemistry and Bioactive Compounds
- Pharmacological Effects of Natural Compounds
- Glycosylation and Glycoproteins Research
- Systemic Lupus Erythematosus Research
- Carbohydrate Chemistry and Synthesis
- Pneumonia and Respiratory Infections
- Traditional Chinese Medicine Analysis
- RNA and protein synthesis mechanisms
- Phytochemical Studies and Bioactivities
- Medical Coding and Health Information
- Viral Infections and Immunology Research
- Cancer Mechanisms and Therapy
- Complement system in diseases
- Smoking Behavior and Cessation
- Digital Humanities and Scholarship
Binzhou University
2025
Binzhou Medical University
2025
Kunming University of Science and Technology
2014-2024
Health Commission of Anhui Province
2024
Zhejiang Chinese Medical University
2024
Dongfeng General Hospital
2024
China National Pharmaceutical Group Corporation (China)
2024
Hubei University of Medicine
2024
Peking University
2011-2023
Hebei Normal University
2023
Entry inhibitors are of particular importance in current efforts to develop a new generation anti-influenza virus drugs. Here we report certain pentacyclic triterpenes exhibiting conserved structure features and with vitro activity comparable even higher than that oseltamivir. Mechanistic studies indicated these lead triterpenoids bind tightly the viral envelope hemagglutinin (HA), disrupting interaction HA sialic acid receptor thus attachment viruses host cells. Docking suggest binding...
Proteolytic cleavage of influenza A virus (IAV) hemagglutinin by host proteases is crucial for infectivity and spread. The transmembrane serine protease TMPRSS2 was previously identified as the essential that can cleave many subtypes spike protein coronavirus. Herein, we found a guanine rich tract, capable forming intramolecular G-quadruplex in presence potassium ions, promoter region human gene quite important transcriptional activity, hence affecting its function. Furthermore, 7 new...
Objective To assess the Knowledge, Attitudes and Practices (KAP) among healthcare professionals in managing patients with coexisting hypertension bronchial asthma. Design A cross-sectional survey. The reporting of this study followed Strengthening Reporting Observational Studies Epidemiology checklist. Setting From 30 March to 15 April 2024 at 66 various level hospitals community health service centres. Participants Physicians nurses specialising clinical internal medicine, each over 2 years...
Glioblastoma is the most aggressive brain tumor, and its prognosis remains poor. Therefore, novel therapeutic strategies are needed for glioma therapy. Polyphyllin I (PPI), a bioactive constituent extracted from Paris polyphylla, was reported to have anti-tumor activity. However, detailed mechanism this activity unclear. Here, we investigated inhibitory effects of PPI on cells mechanisms in vitro. U251 were treated with various concentrations (2–9 μM) 24 72 h. The inhibition cell...
Objective In this study we assess clinicopathologic characteristics, treatment and prognosis of acute kidney injury (AKI) in a large cohort Chinese patients with lupus nephritis. Methods The clinical, laboratory, renal histopathology, outcome data were retrospectively collected compared between nephritis without AKI. impact AKI on was evaluated. Results Among 322 biopsy-proven nephritis, 66 (20.5%) identified as Male predominance observed ( p < 0.001). comparison the non-AKI group, had...
Objective Our previous study showed that plasma levels of factor H (FH) were significantly decreased in patients with lupus nephritis and reflected activity. The aim this was to further investigate vitro biofunctions FH nephritis. Methods purified from the first run exchange four active two non-renal involvement systemic erythematosus (SLE) patients, healthy controls. Then, analyzed. In addition, exons sequencing analysis performed. Results Homogeneous fractions purity comparable commercial...
Oleanolic acid (OA) was discovered as a mild influenza hemagglutinin (HA) inhibitor in our earlier studies. In the present work, 20 compounds were prepared by structural modifications of OA, and their antiviral activities against A/WSN/33 (H1N1) virus Madin-Darby canine kidney (MDCK) cells evaluated. Based on biological result, structure-activity relationship (SAR) discussed. Compound 10 with six-carbon chain terminal hydroxyl group showed strongest anti-influenza activity an IC50 2.98 µM,...
Influenza is a major threat to millions of people worldwide. Entry inhibitors are particular interest for the development novel therapeutic strategies influenza. We have previously discovered oleanolic acid (OA) be mild influenza hemagglutinin (HA) inhibitor. In this work, inspired by 3D structure HA as homotrimeric receptor, we designed and synthesized 15 OA trimers with different linkers central region via copper-catalyzed azide–alkyne cycloaddition reaction. All were evaluated their...
Symbiotic plants might be able to regulate a limited nitrogen (N) pool, thus avoiding and reducing competition for resources, through the uptake of different chemical N forms. Our aim was see whether coexisting herbs showed preference forms in temperate desert. We conducted situ experiment using 15 labeling method Gurbantunggut Desert Northwestern China dominated by Erodium oxyrrhynchum, Hyalea pulchella, Nonea caspica Lactuca undulata during their growing period (April May). Four desert...
Two new oleanane triterpenoid saponins, bodiniosides Q (1) and R (2), along with five known niga-ichigoside F1 (3), 3-O-[β-D-glucopyranosyl]-28-O-[α-L-rhamnopyranosyl -(1→2)-β-D-glucopyranosyl] arjunolic acid (4), asiaticoside E (5), sericoside (6), bodinioside (7), were isolated from the aerial parts of Elsholtzia bodinieri. The structures 1 2 characterized by spectroscopic techniques chemical evidence as 3-O-β-D- xylopyranosyl-2α, 23-dihydroxy-olean-12-en-28-oic 28-O-α-L-rhamnopyranosyl-...
A new prenylated 3-benzoxepin derivative, elsholtzioxin (1), together with fifteen known compounds (2-16) were isolated from the whole parts of Elsholtzia penduliflora. Their structures elucidated on basis various spectroscopic techniques and chemical evidences. The antiviral activities these evaluated in vitro. compound (1) exhibited potential anti-influenza virus activity against strain A/WSN/33/2009 (H1N1) inhibition rate 47.19%. Compounds 2, 9 12 significant inhibitory IC50 value 26.16,...
A series of triterpene dimers bearing different scaffold were designed and synthesized via CuAAC reaction. Their anti‐HCV entry activities evaluated by HCVpp VSVpp assays. It was found that echinocystic acid (EA) its dimer still necessary for maintaining activity, replacement EA other triterpenes might significantly decrease anti‐viral activities. Using a linker piperazine group, compound 14 dramatically increased potency with IC 50 at 2.87 nmol/L. In addition, the undesired hemolytic effect...
To investigate the expression of serum miR-155 in children with Mycoplasma pneumoniae pneumonia (MPP).A total 100 at our hospital caused by infection were enrolled as a study group, including 45 cases acute phase (acute group) and 55 recovery (recovery group). An additional 30 healthy during same period control group. The levels miR-155, tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-10, IL-13, immunoglobulin (Ig) G, IgA, complements (C3 CH50), T lymphocyte subsets (CD3+, CD4+,...