A5053254728- Immune Cell Function and Interaction
- Diabetes and associated disorders
- Molecular Biology Techniques and Applications
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- IL-33, ST2, and ILC Pathways
- Pneumonia and Respiratory Infections
- Fungal Biology and Applications
- Sulfur Compounds in Biology
- Viral Infectious Diseases and Gene Expression in Insects
- Cardiovascular Health and Risk Factors
- Diabetes Management and Research
- RNA modifications and cancer
- Pancreatic function and diabetes
- Congenital Heart Disease Studies
- Radiomics and Machine Learning in Medical Imaging
- Insect Resistance and Genetics
- Tuberculosis Research and Epidemiology
- Enzyme Production and Characterization
- Galectins and Cancer Biology
- Pulmonary Hypertension Research and Treatments
- Ultrasound in Clinical Applications
- Pineapple and bromelain studies
- Brain Tumor Detection and Classification
- Inflammasome and immune disorders
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Xiyuan Hospital
2024-2025
Xinjiang Medical University
2021-2024
University of South China
2024
Jiangsu Normal University
2015-2023
Soochow University
2017-2023
Southwest Medical University
2023
Huazhong University of Science and Technology
2023
Tongji Hospital
2023
Xuzhou Medical College
2021-2022
Vascular calcification (VC) commonly occurs in diabetes and is associated with cardiovascular disease incidence mortality. Currently, there no drug treatment for VC. The Danlian-Tongmai formula (DLTM) a traditional Chinese medicine (TCM) prescription used diabetic VC (DVC), but its mechanisms of action remain unclear. This study aims to elucidate the effects DLTM on DVC explore underlying action. Ultra-high-performance liquid chromatography-mass spectrometry (UHPLC-MS) was identify...
Background Cardiovascular Disease (CVD) is the leading cause of global mortality, with its incidence rate rising year by due to prevalence metabolic diseases. Existing primary and secondary prevention strategies for cardiovascular disease have limitations in identifying some high-risk groups, 1.5-level aims achieve more precise intervention early identification subclinical target organ damage. This study introduces oral (tongue coating) microbiota as markers first time, combination multiple...
Background: A complex relationship exists between obstructive sleep apnea syndrome and diabetes mellitus (DM). Chronic intermittent hypoxia (CIH), which is a core pathological feature of syndrome, may play an important role in the onset development DM-related atherosclerosis (DM-AS). This study aimed to investigate mechanism action tetramethylpyrazine (TMP) CIH-associated DM-AS. Methods: In vivo , DM-AS mouse model was established by intraperitoneal injection streptozotocin combined with...
Objective . To investigate the value of contrast-enhanced ultrasound (CEUS) in transthoracic biopsy peripheral lung and mediastinal lesions. Methods Of 142 patients, 82 patients received CEUS before were defined as group. The remaining 60 only underwent conventional (US) served US information was used for selecting indication instructing biopsy. imaging features, number punctures, diagnostic successful rate, complication rate between two groups compared. Results Necrosis demonstrated 43.9%...
Background: Deep learning (DL) could predict isocitrate dehydrogenase (IDH) mutation status from MRIs. Yet, previous work focused on CNNs with refined tumor segmentation. To bridge the gap, this study aimed to evaluate feasibility of developing a Transformer-based network IDH free Methods: A total 493 glioma patients were recruited two independent institutions for model development (TCIA; N = 259) and external test (AHXZ; 234). was predicted directly T2 images Swin Transformer conventional...
Abstract Background Glycoside hydrolase (GH) family 30 xylanases are a distinct group of xylanases, most which have highly specific catalytic activity for glucuronoxylan. Since GH30 do not normally carry carbohydrate-binding modules (CBMs), our knowledge the function their CBMs is lacking. Results In this work, CBM functions CrXyl30 were investigated. was glucuronoxylanase containing tandem CBM13 (CrCBM13) and CBM2 (CrCBM2) at its C terminus, identified in lignocellulolytic bacterial...
Abstract The parasitoid Exorista sorbillans (Diptera: Tachinidae) is a larval endoparasitoid of the silkworm Bombyx mori , causing severe damage to cocoon industry. It also an important natural enemy resource insect pests in agriculture and forestry. Despite their roles biocontrol pest status on sericulture, there has been limited research functional studies dipteran parasitoids. Quantitative real‐time polymerase chain reaction (qRT‐PCR) most commonly used address gene functions. Using...
We propose an agent-based model for the simulation of autoimmune response in T1D. The incorporates cell behavior from various rules derived current literature and is implemented on a high-performance computing system, which enables significant portion islets mouse pancreas. Simulation results indicate that able to capture trends emerge during progression autoimmunity. multi-scale nature definition or equations govern cellular sub-cellular level phenomena observation outcomes at tissue scale....
Primary soft tissue non-Hodgkin lymphoma (NHL) of the extremities is very rare. The clinical features NHL mimic those other tumors, particularly sarcoma; however, they should be differentiated, as treatment and prognosis are completely different. In this study, case a 68-year-old female with giant mass, movement disorder, numbness painful sensations in right thigh presented. Magnetic resonance (MR) imaging revealed huge circle-shaped mass. Fine needle aspiration cytology (FNAC) tumor...
Abstract The silkworm Bombyx mori (Lepidoptera: Bombycidae) is a lepidopteran model insect of great economic importance. parasitoid Exorista sorbillans (Diptera, Tachinidae) the major pest B. and also promising candidate for biological control. However, molecular interactions between hosts dipteran parasitoids have only partially been studied. Gene expression analysis by reverse-transcription quantitative real-time polymerase chain reaction (RT-qPCR) indispensable to characterise their...
Three undescribed lanostane triterpenoids, 24E-en-11-oxo-ganoderiol D (1), 11β-hydroxy-ganoderiol (2), and 11β-hydroxy-lucidone H (3) were isolated from the 80% EtOH extract of fruiting bodies Ganoderma hainanense. Structural elucidation all compounds performed by spectral methods such as 1 2 (1H-1H COSY, HMQC, HMBC) NMR spectroscopy. All triterpenoids in vitro evaluated for their cytotoxic activities against six mammary adenocarcinoma cell lines (MCF7, MDA-MB-231, SK-BR-3, BT-20, HCC38,...
<title>Abstract</title> Purpose Kawasaki disease (KD) is an acute vasculitis affecting mainly young children and can cause serious coronary artery abnormalities. This study evaluated interleukin-6 (IL-6) as a biomarker for early KD diagnosis treatment. Methods In retrospective study, 275 with were analyzed, alongside 109 other infectious diseases, to assess IL-6's diagnostic specificity. Patients categorized by lesions (CAL) presence type. Results Of the patients (mean age 2.45 years), 84...
To investigate the expression of serum miR-155 in children with Mycoplasma pneumoniae pneumonia (MPP).A total 100 at our hospital caused by infection were enrolled as a study group, including 45 cases acute phase (acute group) and 55 recovery (recovery group). An additional 30 healthy during same period control group. The levels miR-155, tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), IL-10, IL-13, immunoglobulin (Ig) G, IgA, complements (C3 CH50), T lymphocyte subsets (CD3+, CD4+,...
Objective To analyze serum levels of inhibitory costimulatory molecules and their correlations with innate immune cytokine in patients pulmonary tuberculosis (PTB). Methods Data for 280 PTB healthy individuals were collected. Serum measured using ELISA. Univariate, multivariate, subgroup, matrix correlation, receiver operating characteristic curve analyses performed. Results Host, environment, lifestyle, clinical features, medical history all influenced PTB. soluble programmed death ligand 1...